Analysis of Margin Index as a Method for Predicting Residual Disease After Breast-Conserving Surgery in a European Cancer Center.

Hdl Handle:
http://hdl.handle.net/10147/136341
Title:
Analysis of Margin Index as a Method for Predicting Residual Disease After Breast-Conserving Surgery in a European Cancer Center.
Authors:
Bolger, Jarlath C; Solon, Jacqueline G; Power, Colm; Hill, Arnold D K
Affiliation:
Department of Surgery, Beaumont Hospital, Dublin 9, Ireland, jarlathbolger@yahoo.co.uk.
Citation:
Analysis of Margin Index as a Method for Predicting Residual Disease After Breast-Conserving Surgery in a European Cancer Center. 2011:notAnn Surg Oncol
Journal:
Annals of surgical oncology
Issue Date:
3-Jun-2011
URI:
http://hdl.handle.net/10147/136341
DOI:
10.1245/s10434-011-1810-4
PubMed ID:
21638098
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/21638098
Abstract:
INTRODUCTION: Breast-conserving surgery (BCS), followed by appropriate adjuvant therapies is established as a standard treatment option for women with early-stage invasive breast cancers. A number of factors have been shown to correlate with local and regional disease recurrence. Although margin status is a strong predictor of disease recurrence, consensus is yet to be established on the optimum margin necessary. Margenthaler et al. recently proposed the use of a "margin index," combining tumor size and margin status as a predictor of residual disease after BCS. We applied this new predictive tool to a population of patients with primary breast cancer who presented to a symptomatic breast unit to determine its suitability in predicting those who require reexcision surgery. METHODS: Retrospective analysis of our breast cancer database from January 1, 2000 to June 30, 2010 was performed, including all patients who underwent BCS. Of 531 patients who underwent BCS, 27.1% (144/531) required further reexcision procedures, and 55 were eligible for inclusion in the study. Margin index was calculated as: margin index = closest margin (mm)/tumor size (mm) × 100, with index >5 considered optimum. RESULTS: Of the 55 patients included, 31% (17/55) had residual disease. Fisher's exact test showed margin index not to be a significant predictor of residual disease on reexcision specimen (P = 0.57). Of note, a significantly higher proportion of our patients presented with T2/3 tumors (60% vs. 38%). CONCLUSIONS: Although an apparently elegant tool for predicting residual disease after BCS, we have shown that it is not applicable to a symptomatic breast unit in Ireland.
Item Type:
Article
Language:
en
ISSN:
1534-4681

Full metadata record

DC FieldValue Language
dc.contributor.authorBolger, Jarlath Cen
dc.contributor.authorSolon, Jacqueline Gen
dc.contributor.authorPower, Colmen
dc.contributor.authorHill, Arnold D Ken
dc.date.accessioned2011-07-19T13:48:58Z-
dc.date.available2011-07-19T13:48:58Z-
dc.date.issued2011-06-03-
dc.identifier.citationAnalysis of Margin Index as a Method for Predicting Residual Disease After Breast-Conserving Surgery in a European Cancer Center. 2011:notAnn Surg Oncolen
dc.identifier.issn1534-4681-
dc.identifier.pmid21638098-
dc.identifier.doi10.1245/s10434-011-1810-4-
dc.identifier.urihttp://hdl.handle.net/10147/136341-
dc.description.abstractINTRODUCTION: Breast-conserving surgery (BCS), followed by appropriate adjuvant therapies is established as a standard treatment option for women with early-stage invasive breast cancers. A number of factors have been shown to correlate with local and regional disease recurrence. Although margin status is a strong predictor of disease recurrence, consensus is yet to be established on the optimum margin necessary. Margenthaler et al. recently proposed the use of a "margin index," combining tumor size and margin status as a predictor of residual disease after BCS. We applied this new predictive tool to a population of patients with primary breast cancer who presented to a symptomatic breast unit to determine its suitability in predicting those who require reexcision surgery. METHODS: Retrospective analysis of our breast cancer database from January 1, 2000 to June 30, 2010 was performed, including all patients who underwent BCS. Of 531 patients who underwent BCS, 27.1% (144/531) required further reexcision procedures, and 55 were eligible for inclusion in the study. Margin index was calculated as: margin index = closest margin (mm)/tumor size (mm) × 100, with index >5 considered optimum. RESULTS: Of the 55 patients included, 31% (17/55) had residual disease. Fisher's exact test showed margin index not to be a significant predictor of residual disease on reexcision specimen (P = 0.57). Of note, a significantly higher proportion of our patients presented with T2/3 tumors (60% vs. 38%). CONCLUSIONS: Although an apparently elegant tool for predicting residual disease after BCS, we have shown that it is not applicable to a symptomatic breast unit in Ireland.-
dc.languageENG-
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21638098en
dc.titleAnalysis of Margin Index as a Method for Predicting Residual Disease After Breast-Conserving Surgery in a European Cancer Center.en
dc.typeArticleen
dc.contributor.departmentDepartment of Surgery, Beaumont Hospital, Dublin 9, Ireland, jarlathbolger@yahoo.co.uk.en
dc.identifier.journalAnnals of surgical oncologyen
dc.description.provinceLeinster-

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