In touch with psoriasis: topical treatments and current guidelines.

Hdl Handle:
http://hdl.handle.net/10147/136009
Title:
In touch with psoriasis: topical treatments and current guidelines.
Authors:
Murphy, G; Reich, K
Affiliation:
National Photobiology Unit Beaumont & Mater Hospitals, Dermatology Department, Beaumont Hospital, Dublin, Ireland. gillianmmurphy@gmail.com
Citation:
In touch with psoriasis: topical treatments and current guidelines. 2011, 25 Suppl 4:3-8 J Eur Acad Dermatol Venereol
Journal:
Journal of the European Academy of Dermatology and Venereology : JEADV
Issue Date:
Jun-2011
URI:
http://hdl.handle.net/10147/136009
DOI:
10.1111/j.1468-3083.2011.04059.x
PubMed ID:
21507077
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/21507077
Abstract:
This article describes topical therapies and treatment guidelines for psoriasis and is based on a presentation given by the authors at a satellite symposium held during the 19th Congress of the European Academy of Dermatology and Venereology, 6-10 October, 2010, in Gothenburg, Sweden. The highly variable nature of psoriasis and its individual presentation in patients can make it difficult to choose the most appropriate treatment. There are many treatment options, from topical treatment with emollients for very mild psoriasis, to systemic therapy with fumaric acid esters, methotrexate or biologics for severe disease. For the treatment of mild-to-moderate psoriasis, topical therapy is generally the most appropriate and a variety of options, both historical and recent, are available. Newer therapies offer greater convenience and fewer side-effects. Of the more recently available therapies, vitamin D analogues and topical corticosteroids are the two with the greatest proven efficacy in randomized clinical trials. A recent Cochrane review showed the highest efficacy overall with the fixed combination vitamin D analogue (calcipotriol) and corticosteroid (betamethasone dipropionate). Indeed, clinical trials have shown that two-compound calcipotriol/betamethasone dipropionate ointment has higher efficacy than calcipotriol or betamethasone dipropionate alone. With regard to safety, two-compound calcipotriol/betamethasone dipropionate was shown to be suitable for intermittent long-term treatment of mild-to-moderate psoriasis. The findings of the Cochrane review are reflected in the current treatment guidelines from the USA and Germany regarding the treatment of mild-to-moderate psoriasis. In both these guidelines, which will be discussed in this article, the recommended treatments for this patient group are vitamin D analogues and corticosteroids, particularly when used in combination.
Item Type:
Article
Language:
en
MeSH:
Administration, Topical; Betamethasone; Calcitriol; Dermatologic Agents; Humans; Practice Guidelines as Topic; Psoriasis
ISSN:
1468-3083

Full metadata record

DC FieldValue Language
dc.contributor.authorMurphy, Gen
dc.contributor.authorReich, Ken
dc.date.accessioned2011-07-13T15:10:42Z-
dc.date.available2011-07-13T15:10:42Z-
dc.date.issued2011-06-
dc.identifier.citationIn touch with psoriasis: topical treatments and current guidelines. 2011, 25 Suppl 4:3-8 J Eur Acad Dermatol Venereolen
dc.identifier.issn1468-3083-
dc.identifier.pmid21507077-
dc.identifier.doi10.1111/j.1468-3083.2011.04059.x-
dc.identifier.urihttp://hdl.handle.net/10147/136009-
dc.description.abstractThis article describes topical therapies and treatment guidelines for psoriasis and is based on a presentation given by the authors at a satellite symposium held during the 19th Congress of the European Academy of Dermatology and Venereology, 6-10 October, 2010, in Gothenburg, Sweden. The highly variable nature of psoriasis and its individual presentation in patients can make it difficult to choose the most appropriate treatment. There are many treatment options, from topical treatment with emollients for very mild psoriasis, to systemic therapy with fumaric acid esters, methotrexate or biologics for severe disease. For the treatment of mild-to-moderate psoriasis, topical therapy is generally the most appropriate and a variety of options, both historical and recent, are available. Newer therapies offer greater convenience and fewer side-effects. Of the more recently available therapies, vitamin D analogues and topical corticosteroids are the two with the greatest proven efficacy in randomized clinical trials. A recent Cochrane review showed the highest efficacy overall with the fixed combination vitamin D analogue (calcipotriol) and corticosteroid (betamethasone dipropionate). Indeed, clinical trials have shown that two-compound calcipotriol/betamethasone dipropionate ointment has higher efficacy than calcipotriol or betamethasone dipropionate alone. With regard to safety, two-compound calcipotriol/betamethasone dipropionate was shown to be suitable for intermittent long-term treatment of mild-to-moderate psoriasis. The findings of the Cochrane review are reflected in the current treatment guidelines from the USA and Germany regarding the treatment of mild-to-moderate psoriasis. In both these guidelines, which will be discussed in this article, the recommended treatments for this patient group are vitamin D analogues and corticosteroids, particularly when used in combination.-
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21507077en
dc.subject.meshAdministration, Topical-
dc.subject.meshBetamethasone-
dc.subject.meshCalcitriol-
dc.subject.meshDermatologic Agents-
dc.subject.meshHumans-
dc.subject.meshPractice Guidelines as Topic-
dc.subject.meshPsoriasis-
dc.titleIn touch with psoriasis: topical treatments and current guidelines.en
dc.typeArticleen
dc.contributor.departmentNational Photobiology Unit Beaumont & Mater Hospitals, Dermatology Department, Beaumont Hospital, Dublin, Ireland. gillianmmurphy@gmail.comen
dc.identifier.journalJournal of the European Academy of Dermatology and Venereology : JEADVen
dc.description.provinceLeinster-
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