A complete analysis of HA and NA genes of influenza A viruses.

Hdl Handle:
http://hdl.handle.net/10147/135989
Title:
A complete analysis of HA and NA genes of influenza A viruses.
Authors:
Shi, Weifeng; Lei, Fumin; Zhu, Chaodong; Sievers, Fabian; Higgins, Desmond G
Affiliation:
The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland. weifeng.shi@ucd.ie
Citation:
A complete analysis of HA and NA genes of influenza A viruses. 2010, 5 (12):e14454 PLoS ONE
Journal:
PloS one
Issue Date:
Dec-2010
URI:
http://hdl.handle.net/10147/135989
DOI:
10.1371/journal.pone.0014454
PubMed ID:
21209922
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/21209922
Abstract:
More and more nucleotide sequences of type A influenza virus are available in public databases. Although these sequences have been the focus of many molecular epidemiological and phylogenetic analyses, most studies only deal with a few representative sequences. In this paper, we present a complete analysis of all Haemagglutinin (HA) and Neuraminidase (NA) gene sequences available to allow large scale analyses of the evolution and epidemiology of type A influenza.; This paper describes an analysis and complete classification of all HA and NA gene sequences available in public databases using multivariate and phylogenetic methods.; We analyzed 18,975 HA sequences and divided them into 280 subgroups according to multivariate and phylogenetic analyses. Similarly, we divided 11,362 NA sequences into 202 subgroups. Compared to previous analyses, this work is more detailed and comprehensive, especially for the bigger datasets. Therefore, it can be used to show the full and complex phylogenetic diversity and provides a framework for studying the molecular evolution and epidemiology of type A influenza virus. For more than 85% of type A influenza HA and NA sequences into GenBank, they are categorized in one unambiguous and unique group. Therefore, our results are a kind of genetic and phylogenetic annotation for influenza HA and NA sequences. In addition, sequences of swine influenza viruses come from 56 HA and 45 NA subgroups. Most of these subgroups also include viruses from other hosts indicating cross species transmission of the viruses between pigs and other hosts. Furthermore, the phylogenetic diversity of swine influenza viruses from Eurasia is greater than that of North American strains and both of them are becoming more diverse. Apart from viruses from human, pigs, birds and horses, viruses from other species show very low phylogenetic diversity. This might indicate that viruses have not become established in these species. Based on current evidence, there is no simple pattern of inter-hemisphere transmission of avian influenza viruses and it appears to happen sporadically. However, for H6 subtype avian influenza viruses, such transmissions might have happened very frequently and multiple and bidirectional transmission events might exist.
Item Type:
Article
Language:
en
MeSH:
Animals; Birds; Databases, Genetic; Evolution, Molecular; Genetic Variation; Geography; Hemagglutinins; Humans; Influenza A virus; Influenza in Birds; Influenza, Human; Multivariate Analysis; Neuraminidase; Phylogeny
ISSN:
1932-6203

Full metadata record

DC FieldValue Language
dc.contributor.authorShi, Weifengen
dc.contributor.authorLei, Fuminen
dc.contributor.authorZhu, Chaodongen
dc.contributor.authorSievers, Fabianen
dc.contributor.authorHiggins, Desmond Gen
dc.date.accessioned2011-07-13T15:10:21Z-
dc.date.available2011-07-13T15:10:21Z-
dc.date.issued2010-12-
dc.identifier.citationA complete analysis of HA and NA genes of influenza A viruses. 2010, 5 (12):e14454 PLoS ONEen
dc.identifier.issn1932-6203-
dc.identifier.pmid21209922-
dc.identifier.doi10.1371/journal.pone.0014454-
dc.identifier.urihttp://hdl.handle.net/10147/135989-
dc.description.abstractMore and more nucleotide sequences of type A influenza virus are available in public databases. Although these sequences have been the focus of many molecular epidemiological and phylogenetic analyses, most studies only deal with a few representative sequences. In this paper, we present a complete analysis of all Haemagglutinin (HA) and Neuraminidase (NA) gene sequences available to allow large scale analyses of the evolution and epidemiology of type A influenza.-
dc.description.abstractThis paper describes an analysis and complete classification of all HA and NA gene sequences available in public databases using multivariate and phylogenetic methods.-
dc.description.abstractWe analyzed 18,975 HA sequences and divided them into 280 subgroups according to multivariate and phylogenetic analyses. Similarly, we divided 11,362 NA sequences into 202 subgroups. Compared to previous analyses, this work is more detailed and comprehensive, especially for the bigger datasets. Therefore, it can be used to show the full and complex phylogenetic diversity and provides a framework for studying the molecular evolution and epidemiology of type A influenza virus. For more than 85% of type A influenza HA and NA sequences into GenBank, they are categorized in one unambiguous and unique group. Therefore, our results are a kind of genetic and phylogenetic annotation for influenza HA and NA sequences. In addition, sequences of swine influenza viruses come from 56 HA and 45 NA subgroups. Most of these subgroups also include viruses from other hosts indicating cross species transmission of the viruses between pigs and other hosts. Furthermore, the phylogenetic diversity of swine influenza viruses from Eurasia is greater than that of North American strains and both of them are becoming more diverse. Apart from viruses from human, pigs, birds and horses, viruses from other species show very low phylogenetic diversity. This might indicate that viruses have not become established in these species. Based on current evidence, there is no simple pattern of inter-hemisphere transmission of avian influenza viruses and it appears to happen sporadically. However, for H6 subtype avian influenza viruses, such transmissions might have happened very frequently and multiple and bidirectional transmission events might exist.-
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21209922en
dc.subject.meshAnimals-
dc.subject.meshBirds-
dc.subject.meshDatabases, Genetic-
dc.subject.meshEvolution, Molecular-
dc.subject.meshGenetic Variation-
dc.subject.meshGeography-
dc.subject.meshHemagglutinins-
dc.subject.meshHumans-
dc.subject.meshInfluenza A virus-
dc.subject.meshInfluenza in Birds-
dc.subject.meshInfluenza, Human-
dc.subject.meshMultivariate Analysis-
dc.subject.meshNeuraminidase-
dc.subject.meshPhylogeny-
dc.titleA complete analysis of HA and NA genes of influenza A viruses.en
dc.typeArticleen
dc.contributor.departmentThe Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland. weifeng.shi@ucd.ieen
dc.identifier.journalPloS oneen

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