Cross-clamp time is an independent predictor of mortality and morbidity in low- and high-risk cardiac patients.

Hdl Handle:
http://hdl.handle.net/10147/135803
Title:
Cross-clamp time is an independent predictor of mortality and morbidity in low- and high-risk cardiac patients.
Authors:
Al-Sarraf, Nael; Thalib, Lukman; Hughes, Anne; Houlihan, Maighread; Tolan, Michael; Young, Vincent; McGovern, Eillish
Affiliation:
Department of Cardiothoracic Surgery, St. James's Hospital, Dublin 8, Ireland. trinityq8@hotmail.com
Citation:
Cross-clamp time is an independent predictor of mortality and morbidity in low- and high-risk cardiac patients. 2011, 9 (1):104-9 Int J Surg
Journal:
International journal of surgery (London, England)
Issue Date:
Oct-2011
URI:
http://hdl.handle.net/10147/135803
DOI:
10.1016/j.ijsu.2010.10.007
PubMed ID:
20965288
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/20965288
Abstract:
We sought to assess the effects of aortic cross-clamp time (XCL) on outcome following cardiac surgery in low- and high-risk patients.; This is a retrospective review of prospectively collected departmental data of all patients who underwent cardiac surgery over 8-year period. Our cohort consisted of 3799 consecutive patients subdivided into low-risk (Euro SCORE < 6, n = 2691, 71%) and high-risk (Euro SCORE ≥ 6, n = 1108, 29%). Each class was further stratified into three groups based on their corresponding XCL time. Group 1 (XCL ≤ 60 min), group 2 (XCL > 60 but ≤ 90 min) and group 3 (XCL >90 min). Postoperative morbidity and in-hospital mortality were analysed.; Univariate analysis showed the following to be significantly associated with increased XCL time in both low- and high-risk patients: low cardiac output, prolonged ventilation time, renal complications, prolonged hospital stay, blood transfusion and increased mortality (p < 0.05). By using multiple logistic regression, aortic XCL time >60 min was independent risk factor for low cardiac output, prolonged ventilation, renal complication, blood transfusion, mortality and prolonged hospital stay in both groups. By using XCL time as a continuous variable, an incremental increase of 1 min interval in XCL time was associated with a 2% increase in mortality in both groups.; Prolonged cross-clamp time significantly correlates with major post-operative morbidity and mortality in both low- and high-risk patients. This effect increases with increasing XCL time. Prior knowledge on this effect can help in preventing some of these complications.
Item Type:
Article
Language:
en
MeSH:
Adult; Aged; Aged, 80 and over; Aorta; Cardiac Surgical Procedures; Cohort Studies; Constriction; Female; Heart Diseases; Hospital Mortality; Humans; Logistic Models; Male; Middle Aged; Retrospective Studies; Risk Factors; Time Factors; Treatment Outcome; Young Adult
ISSN:
1743-9159

Full metadata record

DC FieldValue Language
dc.contributor.authorAl-Sarraf, Naelen
dc.contributor.authorThalib, Lukmanen
dc.contributor.authorHughes, Anneen
dc.contributor.authorHoulihan, Maighreaden
dc.contributor.authorTolan, Michaelen
dc.contributor.authorYoung, Vincenten
dc.contributor.authorMcGovern, Eillishen
dc.date.accessioned2011-07-11T14:03:24Z-
dc.date.available2011-07-11T14:03:24Z-
dc.date.issued2011-10-
dc.identifier.citationCross-clamp time is an independent predictor of mortality and morbidity in low- and high-risk cardiac patients. 2011, 9 (1):104-9 Int J Surgen
dc.identifier.issn1743-9159-
dc.identifier.pmid20965288-
dc.identifier.doi10.1016/j.ijsu.2010.10.007-
dc.identifier.urihttp://hdl.handle.net/10147/135803-
dc.description.abstractWe sought to assess the effects of aortic cross-clamp time (XCL) on outcome following cardiac surgery in low- and high-risk patients.-
dc.description.abstractThis is a retrospective review of prospectively collected departmental data of all patients who underwent cardiac surgery over 8-year period. Our cohort consisted of 3799 consecutive patients subdivided into low-risk (Euro SCORE < 6, n = 2691, 71%) and high-risk (Euro SCORE ≥ 6, n = 1108, 29%). Each class was further stratified into three groups based on their corresponding XCL time. Group 1 (XCL ≤ 60 min), group 2 (XCL > 60 but ≤ 90 min) and group 3 (XCL >90 min). Postoperative morbidity and in-hospital mortality were analysed.-
dc.description.abstractUnivariate analysis showed the following to be significantly associated with increased XCL time in both low- and high-risk patients: low cardiac output, prolonged ventilation time, renal complications, prolonged hospital stay, blood transfusion and increased mortality (p < 0.05). By using multiple logistic regression, aortic XCL time >60 min was independent risk factor for low cardiac output, prolonged ventilation, renal complication, blood transfusion, mortality and prolonged hospital stay in both groups. By using XCL time as a continuous variable, an incremental increase of 1 min interval in XCL time was associated with a 2% increase in mortality in both groups.-
dc.description.abstractProlonged cross-clamp time significantly correlates with major post-operative morbidity and mortality in both low- and high-risk patients. This effect increases with increasing XCL time. Prior knowledge on this effect can help in preventing some of these complications.-
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/20965288en
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshAorta-
dc.subject.meshCardiac Surgical Procedures-
dc.subject.meshCohort Studies-
dc.subject.meshConstriction-
dc.subject.meshFemale-
dc.subject.meshHeart Diseases-
dc.subject.meshHospital Mortality-
dc.subject.meshHumans-
dc.subject.meshLogistic Models-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshRetrospective Studies-
dc.subject.meshRisk Factors-
dc.subject.meshTime Factors-
dc.subject.meshTreatment Outcome-
dc.subject.meshYoung Adult-
dc.titleCross-clamp time is an independent predictor of mortality and morbidity in low- and high-risk cardiac patients.en
dc.typeArticleen
dc.contributor.departmentDepartment of Cardiothoracic Surgery, St. James's Hospital, Dublin 8, Ireland. trinityq8@hotmail.comen
dc.identifier.journalInternational journal of surgery (London, England)en
dc.description.provinceLeinster-

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