Microbial and viral pathogens in colorectal cancer.

Hdl Handle:
http://hdl.handle.net/10147/135802
Title:
Microbial and viral pathogens in colorectal cancer.
Authors:
Collins, Danielle; Hogan, Aisling M; Winter, Desmond C
Affiliation:
St Vincent's University Hospital and University College Dublin, Dublin 4, Ireland.
Citation:
Microbial and viral pathogens in colorectal cancer. 2011, 12 (5):504-12 Lancet Oncol.
Journal:
The lancet oncology
Issue Date:
May-2011
URI:
http://hdl.handle.net/10147/135802
DOI:
10.1016/S1470-2045(10)70186-8
PubMed ID:
21067973
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/21067973
Abstract:
The heterogenetic and sporadic nature of colorectal cancer has led to many epidemiological associations with causes of this disease. As our understanding of the underlying molecular processes in colorectal-cancer develops, the concept of microbial-epithelial interactions as an oncogenic trigger might provide a plausible hypothesis for the pathogenesis of colorectal cancer. By contrast with other cancers of the gastrointestinal tract (gastric carcinoma, mucosa-associated lymphoid-tissue lymphoma), a direct causal link between microbial infection (bacteria and viruses) and colorectal carcinoma has not been established. Studies support the involvement of these organisms in oncogenesis, however, in colorectal cancer, clinical data are lacking. Here, we discuss current evidence (both in vitro and clinical studies), and focus on a putative role for bacterial and viral pathogens as a cause of colorectal cancer.
Item Type:
Article
Language:
en
MeSH:
Alphapapillomavirus; Bacterial Infections; Bacterial Toxins; Bacteroides; Cell Transformation, Neoplastic; Colorectal Neoplasms; Cyclooxygenase 2; Cytomegalovirus; DNA Damage; Escherichia coli; Free Radicals; Helicobacter pylori; Herpesvirus 4, Human; Humans; Inflammation; JC Virus; NF-kappa B; Neovascularization, Pathologic; Streptococcus bovis; Virus Diseases
ISSN:
1474-5488

Full metadata record

DC FieldValue Language
dc.contributor.authorCollins, Danielleen
dc.contributor.authorHogan, Aisling Men
dc.contributor.authorWinter, Desmond Cen
dc.date.accessioned2011-07-11T14:01:45Z-
dc.date.available2011-07-11T14:01:45Z-
dc.date.issued2011-05-
dc.identifier.citationMicrobial and viral pathogens in colorectal cancer. 2011, 12 (5):504-12 Lancet Oncol.en
dc.identifier.issn1474-5488-
dc.identifier.pmid21067973-
dc.identifier.doi10.1016/S1470-2045(10)70186-8-
dc.identifier.urihttp://hdl.handle.net/10147/135802-
dc.description.abstractThe heterogenetic and sporadic nature of colorectal cancer has led to many epidemiological associations with causes of this disease. As our understanding of the underlying molecular processes in colorectal-cancer develops, the concept of microbial-epithelial interactions as an oncogenic trigger might provide a plausible hypothesis for the pathogenesis of colorectal cancer. By contrast with other cancers of the gastrointestinal tract (gastric carcinoma, mucosa-associated lymphoid-tissue lymphoma), a direct causal link between microbial infection (bacteria and viruses) and colorectal carcinoma has not been established. Studies support the involvement of these organisms in oncogenesis, however, in colorectal cancer, clinical data are lacking. Here, we discuss current evidence (both in vitro and clinical studies), and focus on a putative role for bacterial and viral pathogens as a cause of colorectal cancer.-
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21067973en
dc.subject.meshAlphapapillomavirus-
dc.subject.meshBacterial Infections-
dc.subject.meshBacterial Toxins-
dc.subject.meshBacteroides-
dc.subject.meshCell Transformation, Neoplastic-
dc.subject.meshColorectal Neoplasms-
dc.subject.meshCyclooxygenase 2-
dc.subject.meshCytomegalovirus-
dc.subject.meshDNA Damage-
dc.subject.meshEscherichia coli-
dc.subject.meshFree Radicals-
dc.subject.meshHelicobacter pylori-
dc.subject.meshHerpesvirus 4, Human-
dc.subject.meshHumans-
dc.subject.meshInflammation-
dc.subject.meshJC Virus-
dc.subject.meshNF-kappa B-
dc.subject.meshNeovascularization, Pathologic-
dc.subject.meshStreptococcus bovis-
dc.subject.meshVirus Diseases-
dc.titleMicrobial and viral pathogens in colorectal cancer.en
dc.typeArticleen
dc.contributor.departmentSt Vincent's University Hospital and University College Dublin, Dublin 4, Ireland.en
dc.identifier.journalThe lancet oncologyen
dc.description.provinceLeinster-

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