An assessment of the utility of unselected coagulation screening in general hospital practice.

Hdl Handle:
http://hdl.handle.net/10147/135800
Title:
An assessment of the utility of unselected coagulation screening in general hospital practice.
Authors:
McHugh, Johnny; Holt, Carloyn; O'Keeffe, Denis
Affiliation:
Department of Haematology, Mid Western Regional Hospital, Limerick, Ireland. mchughjohnny@gmail.com
Citation:
An assessment of the utility of unselected coagulation screening in general hospital practice. 2011, 22 (2):106-9 Blood Coagul. Fibrinolysis
Journal:
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
Issue Date:
Mar-2011
URI:
http://hdl.handle.net/10147/135800
DOI:
10.1097/MBC.0b013e3283432fb7
PubMed ID:
21245744
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/21245744
Abstract:
Coagulation screening using prothrombin time (PT) and activated partial thromboplastin time (APTT) is widely used. We performed an audit of coagulation screening in an Irish teaching hospital. We analysed PT and/or APTT results received during normal working hours during a 1-week period in our hospital. Abnormal results due to anticoagulants were excluded from further study. In samples with PT longer than 15.5 s and/or APTT longer than 42 s, we proceeded to 1: 1 mixing studies if the PT was prolonged and 1: 1 mixing studies, factor XII assay and lupus screen if the APTT was prolonged. We also obtained referral source for all samples and clinical details for abnormal samples. Six hundred and seventy-one coagulation requests were received during the study period. Three hundred and eighteen of 671 (47.4%) coagulation requests were for monitoring of anticoagulation. Three hundred and fifty-three of 671 (52.6%) requests were for coagulation screening rather than anticoagulant monitoring. In the coagulation screens received, PT was prolonged in 19 of 353 (5.4%). PT was longer than 20 s in four of 353 cases (1.1%). APTT was prolonged in 19 of 353 (5.4%). APTT was longer than 50 s in four of 353 (1.1%). No patients with abnormal PT or APTT had any bleeding sequelae during the study period. Unregulated coagulation screening has a low yield of abnormal results; the majority of these abnormal results show mild prolongation of PT or APTT with no evidence that they are associated with an increased bleeding risk.
Item Type:
Article
Language:
en
MeSH:
Blood Coagulation; General Practitioners; Hemorrhage; Hospitals, General; Humans; Mass Screening; Partial Thromboplastin Time; Platelet Count; Prothrombin Time; Risk
ISSN:
1473-5733

Full metadata record

DC FieldValue Language
dc.contributor.authorMcHugh, Johnnyen
dc.contributor.authorHolt, Carloynen
dc.contributor.authorO'Keeffe, Denisen
dc.date.accessioned2011-07-11T13:53:37Z-
dc.date.available2011-07-11T13:53:37Z-
dc.date.issued2011-03-
dc.identifier.citationAn assessment of the utility of unselected coagulation screening in general hospital practice. 2011, 22 (2):106-9 Blood Coagul. Fibrinolysisen
dc.identifier.issn1473-5733-
dc.identifier.pmid21245744-
dc.identifier.doi10.1097/MBC.0b013e3283432fb7-
dc.identifier.urihttp://hdl.handle.net/10147/135800-
dc.description.abstractCoagulation screening using prothrombin time (PT) and activated partial thromboplastin time (APTT) is widely used. We performed an audit of coagulation screening in an Irish teaching hospital. We analysed PT and/or APTT results received during normal working hours during a 1-week period in our hospital. Abnormal results due to anticoagulants were excluded from further study. In samples with PT longer than 15.5 s and/or APTT longer than 42 s, we proceeded to 1: 1 mixing studies if the PT was prolonged and 1: 1 mixing studies, factor XII assay and lupus screen if the APTT was prolonged. We also obtained referral source for all samples and clinical details for abnormal samples. Six hundred and seventy-one coagulation requests were received during the study period. Three hundred and eighteen of 671 (47.4%) coagulation requests were for monitoring of anticoagulation. Three hundred and fifty-three of 671 (52.6%) requests were for coagulation screening rather than anticoagulant monitoring. In the coagulation screens received, PT was prolonged in 19 of 353 (5.4%). PT was longer than 20 s in four of 353 cases (1.1%). APTT was prolonged in 19 of 353 (5.4%). APTT was longer than 50 s in four of 353 (1.1%). No patients with abnormal PT or APTT had any bleeding sequelae during the study period. Unregulated coagulation screening has a low yield of abnormal results; the majority of these abnormal results show mild prolongation of PT or APTT with no evidence that they are associated with an increased bleeding risk.-
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21245744en
dc.subject.meshBlood Coagulation-
dc.subject.meshGeneral Practitioners-
dc.subject.meshHemorrhage-
dc.subject.meshHospitals, General-
dc.subject.meshHumans-
dc.subject.meshMass Screening-
dc.subject.meshPartial Thromboplastin Time-
dc.subject.meshPlatelet Count-
dc.subject.meshProthrombin Time-
dc.subject.meshRisk-
dc.titleAn assessment of the utility of unselected coagulation screening in general hospital practice.en
dc.typeArticleen
dc.contributor.departmentDepartment of Haematology, Mid Western Regional Hospital, Limerick, Ireland. mchughjohnny@gmail.comen
dc.identifier.journalBlood coagulation & fibrinolysis : an international journal in haemostasis and thrombosisen
dc.description.provinceMunster-

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