Iron status and chronic kidney disease predict restless legs syndrome in an older hospital population.
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Authors
Quinn, ColinUzbeck, Mateen
Saleem, Imran
Cotter, Paul
Ali, Javed
O'Malley, Grainne
Gilmartin, J J
O'Keeffe, Shaun T
Affiliation
Departments of Geriatric Medicine, Merlin Park University Hospital, Galway, Ireland.Issue Date
2011-03MeSH
Acute DiseaseAged
Aged, 80 and over
Aging
Anemia, Iron-Deficiency
Chronic Disease
Female
Ferritins
Glomerulosclerosis, Focal Segmental
Hospitalization
Humans
Inflammation
Iron
Male
Middle Aged
Predictive Value of Tests
Prevalence
ROC Curve
Renal Insufficiency, Chronic
Restless Legs Syndrome
Risk Factors
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Iron status and chronic kidney disease predict restless legs syndrome in an older hospital population. 2011, 12 (3):295-301 Sleep Med.Journal
Sleep medicineDOI
10.1016/j.sleep.2010.08.014PubMed ID
21317036Additional Links
http://www.ncbi.nlm.nih.gov/pubmed/21317036Abstract
Iron deficiency is important in the pathogenesis of restless legs syndrome (RLS), and serum ferritin measurement, using a cutoff of 45-50ng/ml, is widely recommended as the optimal screening test for iron deficiency in RLS. Serum ferritin often increases with inflammation, and a higher cutoff may be better in those with acute and chronic inflammatory conditions, including those with chronic kidney disease (CKD).The relationships between RLS and potential secondary causes were examined in hospital patients aged 50years or more. Diagnosis of RLS was based on a clinician interview.
Of 301 patients, 55 (18.3%) had RLS. Ferritin levels less than 40ng/ml and between 40 and 69ng/ml and Stage 4 CKD (estimated glomerular filtration rate [eGFR] between 15 and 29ml/min and not on dialysis) were associated with significantly higher odds for RLS in univariate and multivariate analyses.
Iron deficiency and chronic kidney disease are the strongest predictors of RLS in older hospital patients. Ferritin less than 70ng/ml is the best cutoff for identifying possible iron deficiency in RLS patients with inflammatory conditions. Independent of iron status, RLS is strongly associated with chronic kidney disease that is not severe enough to require dialysis, and the results of this study suggest that eGFR values and stages of CKD should be reported in future studies of RLS.
Item Type
ArticleLanguage
enISSN
1878-5506ae974a485f413a2113503eed53cd6c53
10.1016/j.sleep.2010.08.014
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