Iron status and chronic kidney disease predict restless legs syndrome in an older hospital population.

Hdl Handle:
http://hdl.handle.net/10147/135763
Title:
Iron status and chronic kidney disease predict restless legs syndrome in an older hospital population.
Authors:
Quinn, Colin; Uzbeck, Mateen; Saleem, Imran; Cotter, Paul; Ali, Javed; O'Malley, Grainne; Gilmartin, J J; O'Keeffe, Shaun T
Affiliation:
Departments of Geriatric Medicine, Merlin Park University Hospital, Galway, Ireland.
Citation:
Iron status and chronic kidney disease predict restless legs syndrome in an older hospital population. 2011, 12 (3):295-301 Sleep Med.
Journal:
Sleep medicine
Issue Date:
Mar-2011
URI:
http://hdl.handle.net/10147/135763
DOI:
10.1016/j.sleep.2010.08.014
PubMed ID:
21317036
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/21317036
Abstract:
Iron deficiency is important in the pathogenesis of restless legs syndrome (RLS), and serum ferritin measurement, using a cutoff of 45-50ng/ml, is widely recommended as the optimal screening test for iron deficiency in RLS. Serum ferritin often increases with inflammation, and a higher cutoff may be better in those with acute and chronic inflammatory conditions, including those with chronic kidney disease (CKD).; The relationships between RLS and potential secondary causes were examined in hospital patients aged 50years or more. Diagnosis of RLS was based on a clinician interview.; Of 301 patients, 55 (18.3%) had RLS. Ferritin levels less than 40ng/ml and between 40 and 69ng/ml and Stage 4 CKD (estimated glomerular filtration rate [eGFR] between 15 and 29ml/min and not on dialysis) were associated with significantly higher odds for RLS in univariate and multivariate analyses.; Iron deficiency and chronic kidney disease are the strongest predictors of RLS in older hospital patients. Ferritin less than 70ng/ml is the best cutoff for identifying possible iron deficiency in RLS patients with inflammatory conditions. Independent of iron status, RLS is strongly associated with chronic kidney disease that is not severe enough to require dialysis, and the results of this study suggest that eGFR values and stages of CKD should be reported in future studies of RLS.
Item Type:
Article
Language:
en
MeSH:
Acute Disease; Aged; Aged, 80 and over; Aging; Anemia, Iron-Deficiency; Chronic Disease; Female; Ferritins; Glomerulosclerosis, Focal Segmental; Hospitalization; Humans; Inflammation; Iron; Male; Middle Aged; Predictive Value of Tests; Prevalence; ROC Curve; Renal Insufficiency, Chronic; Restless Legs Syndrome; Risk Factors
ISSN:
1878-5506

Full metadata record

DC FieldValue Language
dc.contributor.authorQuinn, Colinen
dc.contributor.authorUzbeck, Mateenen
dc.contributor.authorSaleem, Imranen
dc.contributor.authorCotter, Paulen
dc.contributor.authorAli, Javeden
dc.contributor.authorO'Malley, Grainneen
dc.contributor.authorGilmartin, J Jen
dc.contributor.authorO'Keeffe, Shaun Ten
dc.date.accessioned2011-07-11T13:49:47Z-
dc.date.available2011-07-11T13:49:47Z-
dc.date.issued2011-03-
dc.identifier.citationIron status and chronic kidney disease predict restless legs syndrome in an older hospital population. 2011, 12 (3):295-301 Sleep Med.en
dc.identifier.issn1878-5506-
dc.identifier.pmid21317036-
dc.identifier.doi10.1016/j.sleep.2010.08.014-
dc.identifier.urihttp://hdl.handle.net/10147/135763-
dc.description.abstractIron deficiency is important in the pathogenesis of restless legs syndrome (RLS), and serum ferritin measurement, using a cutoff of 45-50ng/ml, is widely recommended as the optimal screening test for iron deficiency in RLS. Serum ferritin often increases with inflammation, and a higher cutoff may be better in those with acute and chronic inflammatory conditions, including those with chronic kidney disease (CKD).-
dc.description.abstractThe relationships between RLS and potential secondary causes were examined in hospital patients aged 50years or more. Diagnosis of RLS was based on a clinician interview.-
dc.description.abstractOf 301 patients, 55 (18.3%) had RLS. Ferritin levels less than 40ng/ml and between 40 and 69ng/ml and Stage 4 CKD (estimated glomerular filtration rate [eGFR] between 15 and 29ml/min and not on dialysis) were associated with significantly higher odds for RLS in univariate and multivariate analyses.-
dc.description.abstractIron deficiency and chronic kidney disease are the strongest predictors of RLS in older hospital patients. Ferritin less than 70ng/ml is the best cutoff for identifying possible iron deficiency in RLS patients with inflammatory conditions. Independent of iron status, RLS is strongly associated with chronic kidney disease that is not severe enough to require dialysis, and the results of this study suggest that eGFR values and stages of CKD should be reported in future studies of RLS.-
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21317036en
dc.subject.meshAcute Disease-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshAging-
dc.subject.meshAnemia, Iron-Deficiency-
dc.subject.meshChronic Disease-
dc.subject.meshFemale-
dc.subject.meshFerritins-
dc.subject.meshGlomerulosclerosis, Focal Segmental-
dc.subject.meshHospitalization-
dc.subject.meshHumans-
dc.subject.meshInflammation-
dc.subject.meshIron-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshPredictive Value of Tests-
dc.subject.meshPrevalence-
dc.subject.meshROC Curve-
dc.subject.meshRenal Insufficiency, Chronic-
dc.subject.meshRestless Legs Syndrome-
dc.subject.meshRisk Factors-
dc.titleIron status and chronic kidney disease predict restless legs syndrome in an older hospital population.en
dc.typeArticleen
dc.contributor.departmentDepartments of Geriatric Medicine, Merlin Park University Hospital, Galway, Ireland.en
dc.identifier.journalSleep medicineen
dc.description.provinceConnacht-

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