Association between acute statin therapy, survival, and improved functional outcome after ischemic stroke: the North Dublin Population Stroke Study.
Authors
Ní Chróinín, DanielleCallaly, Elizabeth L
Duggan, Joseph
Merwick, Áine
Hannon, Niamh
Sheehan, Órla
Marnane, Michael
Horgan, Gillian
Williams, Emma B
Harris, Dawn
Kyne, Lorraine
McCormack, Patricia M E
Moroney, Joan
Grant, Tim
Williams, David
Daly, Leslie
Kelly, Peter J
Affiliation
Neurovascular Clinical Science Unit, Catherine McCauley Research Centre, Mater University Hospital, Nelson Street, Dublin 7, Ireland. dmmnic@umail.ucc.ieIssue Date
2011-04MeSH
AgedAged, 80 and over
Brain Ischemia
Cholesterol
Cohort Studies
Comorbidity
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Ireland
Male
Middle Aged
Prospective Studies
Recovery of Function
Stroke
Survival Rate
Time
Metadata
Show full item recordCitation
Association between acute statin therapy, survival, and improved functional outcome after ischemic stroke: the North Dublin Population Stroke Study. 2011, 42 (4):1021-9 StrokeJournal
Stroke; a journal of cerebral circulationDOI
10.1161/STROKEAHA.110.596734PubMed ID
21372311Additional Links
http://www.ncbi.nlm.nih.gov/pubmed/21372311Abstract
Statins improve infarct volume and neurological outcome in animal stroke models. We investigated the relationship between statin therapy and ischemic stroke outcome in the North Dublin Population Stroke Study.A population-based prospective cohort study was performed using rigorous ascertainment methods. Prestroke and acute (≤72 hours) poststroke medications were recorded. Modified Rankin score and fatality were assessed at 7, 28, and 90 days and 1 year.
Of 448 ischemic stroke patients, statins were prescribed before stroke onset in 30.1% (134/445) and were begun acutely (≤72 hours) in an additional 42.5% (189/445). On logistic regression analysis, adjusting for age, prestroke disability (modified Rankin scale), NIHSS score, hypertension, and aspirin, new poststroke statin therapy was independently associated with improved early and late survival (compared with statin untreated patients: OR for death, 0.12; CI, 0.03-0.54 at 7 days; OR, 0.19; CI, 0.07-0.48 at 90 days; OR, 0.26; CI, 0.12-0.55 at 1 year; P≤0.006 for all). Similar findings were observed for statin therapy before stroke onset (adjusted OR for death compared with statin-untreated-patients, 0.04; CI, 0.00-0.33; P=0.003 at 7 days; OR, 0.23; CI, 0.09-0.58; P=0.002 at 90 days; OR, 0.48; CI, 0.23-1.01; P=0.05 at 1 year).
Statin therapy at stroke onset and newly begun statins were associated with improved early and late outcomes, supporting data from experimental studies. Randomized trials of statin therapy for treatment of acute stroke are needed.
Item Type
ArticleLanguage
enISSN
1524-4628ae974a485f413a2113503eed53cd6c53
10.1161/STROKEAHA.110.596734
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