Association between acute statin therapy, survival, and improved functional outcome after ischemic stroke: the North Dublin Population Stroke Study.

Hdl Handle:
http://hdl.handle.net/10147/135413
Title:
Association between acute statin therapy, survival, and improved functional outcome after ischemic stroke: the North Dublin Population Stroke Study.
Authors:
Ní Chróinín, Danielle; Callaly, Elizabeth L; Duggan, Joseph; Merwick, Áine; Hannon, Niamh; Sheehan, Órla; Marnane, Michael; Horgan, Gillian; Williams, Emma B; Harris, Dawn; Kyne, Lorraine; McCormack, Patricia M E; Moroney, Joan; Grant, Tim; Williams, David; Daly, Leslie; Kelly, Peter J
Affiliation:
Neurovascular Clinical Science Unit, Catherine McCauley Research Centre, Mater University Hospital, Nelson Street, Dublin 7, Ireland. dmmnic@umail.ucc.ie
Citation:
Association between acute statin therapy, survival, and improved functional outcome after ischemic stroke: the North Dublin Population Stroke Study. 2011, 42 (4):1021-9 Stroke
Journal:
Stroke; a journal of cerebral circulation
Issue Date:
Apr-2011
URI:
http://hdl.handle.net/10147/135413
DOI:
10.1161/STROKEAHA.110.596734
PubMed ID:
21372311
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/21372311
Abstract:
Statins improve infarct volume and neurological outcome in animal stroke models. We investigated the relationship between statin therapy and ischemic stroke outcome in the North Dublin Population Stroke Study.; A population-based prospective cohort study was performed using rigorous ascertainment methods. Prestroke and acute (≤72 hours) poststroke medications were recorded. Modified Rankin score and fatality were assessed at 7, 28, and 90 days and 1 year.; Of 448 ischemic stroke patients, statins were prescribed before stroke onset in 30.1% (134/445) and were begun acutely (≤72 hours) in an additional 42.5% (189/445). On logistic regression analysis, adjusting for age, prestroke disability (modified Rankin scale), NIHSS score, hypertension, and aspirin, new poststroke statin therapy was independently associated with improved early and late survival (compared with statin untreated patients: OR for death, 0.12; CI, 0.03-0.54 at 7 days; OR, 0.19; CI, 0.07-0.48 at 90 days; OR, 0.26; CI, 0.12-0.55 at 1 year; P≤0.006 for all). Similar findings were observed for statin therapy before stroke onset (adjusted OR for death compared with statin-untreated-patients, 0.04; CI, 0.00-0.33; P=0.003 at 7 days; OR, 0.23; CI, 0.09-0.58; P=0.002 at 90 days; OR, 0.48; CI, 0.23-1.01; P=0.05 at 1 year).; Statin therapy at stroke onset and newly begun statins were associated with improved early and late outcomes, supporting data from experimental studies. Randomized trials of statin therapy for treatment of acute stroke are needed.
Item Type:
Article
Language:
en
MeSH:
Aged; Aged, 80 and over; Brain Ischemia; Cholesterol; Cohort Studies; Comorbidity; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ireland; Male; Middle Aged; Prospective Studies; Recovery of Function; Stroke; Survival Rate; Time
ISSN:
1524-4628

Full metadata record

DC FieldValue Language
dc.contributor.authorNí Chróinín, Danielleen
dc.contributor.authorCallaly, Elizabeth Len
dc.contributor.authorDuggan, Josephen
dc.contributor.authorMerwick, Áineen
dc.contributor.authorHannon, Niamhen
dc.contributor.authorSheehan, Órlaen
dc.contributor.authorMarnane, Michaelen
dc.contributor.authorHorgan, Gillianen
dc.contributor.authorWilliams, Emma Ben
dc.contributor.authorHarris, Dawnen
dc.contributor.authorKyne, Lorraineen
dc.contributor.authorMcCormack, Patricia M Een
dc.contributor.authorMoroney, Joanen
dc.contributor.authorGrant, Timen
dc.contributor.authorWilliams, Daviden
dc.contributor.authorDaly, Leslieen
dc.contributor.authorKelly, Peter Jen
dc.date.accessioned2011-07-06T09:29:26Z-
dc.date.available2011-07-06T09:29:26Z-
dc.date.issued2011-04-
dc.identifier.citationAssociation between acute statin therapy, survival, and improved functional outcome after ischemic stroke: the North Dublin Population Stroke Study. 2011, 42 (4):1021-9 Strokeen
dc.identifier.issn1524-4628-
dc.identifier.pmid21372311-
dc.identifier.doi10.1161/STROKEAHA.110.596734-
dc.identifier.urihttp://hdl.handle.net/10147/135413-
dc.description.abstractStatins improve infarct volume and neurological outcome in animal stroke models. We investigated the relationship between statin therapy and ischemic stroke outcome in the North Dublin Population Stroke Study.-
dc.description.abstractA population-based prospective cohort study was performed using rigorous ascertainment methods. Prestroke and acute (≤72 hours) poststroke medications were recorded. Modified Rankin score and fatality were assessed at 7, 28, and 90 days and 1 year.-
dc.description.abstractOf 448 ischemic stroke patients, statins were prescribed before stroke onset in 30.1% (134/445) and were begun acutely (≤72 hours) in an additional 42.5% (189/445). On logistic regression analysis, adjusting for age, prestroke disability (modified Rankin scale), NIHSS score, hypertension, and aspirin, new poststroke statin therapy was independently associated with improved early and late survival (compared with statin untreated patients: OR for death, 0.12; CI, 0.03-0.54 at 7 days; OR, 0.19; CI, 0.07-0.48 at 90 days; OR, 0.26; CI, 0.12-0.55 at 1 year; P≤0.006 for all). Similar findings were observed for statin therapy before stroke onset (adjusted OR for death compared with statin-untreated-patients, 0.04; CI, 0.00-0.33; P=0.003 at 7 days; OR, 0.23; CI, 0.09-0.58; P=0.002 at 90 days; OR, 0.48; CI, 0.23-1.01; P=0.05 at 1 year).-
dc.description.abstractStatin therapy at stroke onset and newly begun statins were associated with improved early and late outcomes, supporting data from experimental studies. Randomized trials of statin therapy for treatment of acute stroke are needed.-
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21372311en
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshBrain Ischemia-
dc.subject.meshCholesterol-
dc.subject.meshCohort Studies-
dc.subject.meshComorbidity-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshHydroxymethylglutaryl-CoA Reductase Inhibitors-
dc.subject.meshIreland-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshProspective Studies-
dc.subject.meshRecovery of Function-
dc.subject.meshStroke-
dc.subject.meshSurvival Rate-
dc.subject.meshTime-
dc.titleAssociation between acute statin therapy, survival, and improved functional outcome after ischemic stroke: the North Dublin Population Stroke Study.en
dc.typeArticleen
dc.contributor.departmentNeurovascular Clinical Science Unit, Catherine McCauley Research Centre, Mater University Hospital, Nelson Street, Dublin 7, Ireland. dmmnic@umail.ucc.ieen
dc.identifier.journalStroke; a journal of cerebral circulationen
dc.description.provinceLeinster-

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