ACTH-secreting bronchial carcinoid: a diagnostic and therapeutic challenge.

Hdl Handle:
http://hdl.handle.net/10147/135374
Title:
ACTH-secreting bronchial carcinoid: a diagnostic and therapeutic challenge.
Authors:
McDermott, J H; Thabit, H; Hickey, N; Thompson, C; Gaffney, E; Young, V; Sreenan, S
Affiliation:
Department of Endocrinology, Royal College of Surgeons, Connolly Hospital Blanchardstown, Dublin 15, Ireland. John.McDermott1@mailc.hse.ie
Citation:
ACTH-secreting bronchial carcinoid: a diagnostic and therapeutic challenge. 2008, 177 (3):269-72 Ir J Med Sci
Journal:
Irish journal of medical science
Issue Date:
Sep-2008
URI:
http://hdl.handle.net/10147/135374
DOI:
10.1007/s11845-008-0171-x
PubMed ID:
18516660
Additional Links:
http://www.springerlink.com/content/g75027v17730m72p/
Abstract:
We describe a case of Cushing's syndrome due to ectopic ACTH secretion, where the only potential source on conventional imaging was a tiny benign-appearing lung nodule, which failed to take up radiolabelled octreotide.; To determine whether the patient might respond to therapeutic administration of octreotide, a test dose was given.; Compared to ACTH and cortisol levels on a control day, the levels following the test dose of octreotide were lower. Subsequent therapeutic administration of subcutaneous octreotide normalised urine free cortisol, with symptomatic improvement, pending evaluation for surgery. Eventual resection of the lung nodule resulted in cure of hypercortisolism. Histological examination of the resected specimen confirmed bronchial carcinoid staining positive for ACTH.; This is one of the few cases described where ectopic ACTH secretion secondary to bronchial carcinoid responded to somatostatin analogue therapy. The case was also unusual in that the tumour responded despite not taking up radiolabelled octreotide.
Item Type:
Article
Language:
en
MeSH:
ACTH Syndrome, Ectopic; Adult; Bronchial Neoplasms; Carcinoid Tumor; Diagnosis, Differential; Humans; Male; Pituitary ACTH Hypersecretion; Tomography, X-Ray Computed
ISSN:
1863-4362

Full metadata record

DC FieldValue Language
dc.contributor.authorMcDermott, J Hen
dc.contributor.authorThabit, Hen
dc.contributor.authorHickey, Nen
dc.contributor.authorThompson, Cen
dc.contributor.authorGaffney, Een
dc.contributor.authorYoung, Ven
dc.contributor.authorSreenan, Sen
dc.date.accessioned2011-07-05T15:18:16Z-
dc.date.available2011-07-05T15:18:16Z-
dc.date.issued2008-09-
dc.identifier.citationACTH-secreting bronchial carcinoid: a diagnostic and therapeutic challenge. 2008, 177 (3):269-72 Ir J Med Scien
dc.identifier.issn1863-4362-
dc.identifier.pmid18516660-
dc.identifier.doi10.1007/s11845-008-0171-x-
dc.identifier.urihttp://hdl.handle.net/10147/135374-
dc.description.abstractWe describe a case of Cushing's syndrome due to ectopic ACTH secretion, where the only potential source on conventional imaging was a tiny benign-appearing lung nodule, which failed to take up radiolabelled octreotide.-
dc.description.abstractTo determine whether the patient might respond to therapeutic administration of octreotide, a test dose was given.-
dc.description.abstractCompared to ACTH and cortisol levels on a control day, the levels following the test dose of octreotide were lower. Subsequent therapeutic administration of subcutaneous octreotide normalised urine free cortisol, with symptomatic improvement, pending evaluation for surgery. Eventual resection of the lung nodule resulted in cure of hypercortisolism. Histological examination of the resected specimen confirmed bronchial carcinoid staining positive for ACTH.-
dc.description.abstractThis is one of the few cases described where ectopic ACTH secretion secondary to bronchial carcinoid responded to somatostatin analogue therapy. The case was also unusual in that the tumour responded despite not taking up radiolabelled octreotide.-
dc.language.isoenen
dc.relation.urlhttp://www.springerlink.com/content/g75027v17730m72p/en
dc.subject.meshACTH Syndrome, Ectopic-
dc.subject.meshAdult-
dc.subject.meshBronchial Neoplasms-
dc.subject.meshCarcinoid Tumor-
dc.subject.meshDiagnosis, Differential-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshPituitary ACTH Hypersecretion-
dc.subject.meshTomography, X-Ray Computed-
dc.titleACTH-secreting bronchial carcinoid: a diagnostic and therapeutic challenge.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Royal College of Surgeons, Connolly Hospital Blanchardstown, Dublin 15, Ireland. John.McDermott1@mailc.hse.ieen
dc.identifier.journalIrish journal of medical scienceen
dc.description.provinceLeinster-

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