Hdl Handle:
http://hdl.handle.net/10147/135091
Title:
Hemostasis in pre-eclampsia.
Authors:
Ismail, Siti Khadijah; Higgins, John R
Affiliation:
Anu Research Centre, Department of Obstetrics and Gynaecology, University College Cork, Cork University Maternity Hospital, Ireland. k.ismail@ucc.ie
Citation:
Hemostasis in pre-eclampsia. 2011, 37 (2):111-7 Semin. Thromb. Hemost.
Journal:
Seminars in thrombosis and hemostasis
Issue Date:
Mar-2011
URI:
http://hdl.handle.net/10147/135091
DOI:
10.1055/s-0030-1270336
PubMed ID:
21370210
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/21370210
Abstract:
Pre-eclampsia (P-EC) is a multisystem disorder exclusive to pregnancy. It complicates ~2 to 8% of all pregnancies and remains a major cause of maternal mortality. P-EC is characterized by a profound hypercoagulable state. The delicate hemostatic balance that must be maintained in the uteroplacental circulation during pregnancy makes this system vulnerable to perturbation. An abnormal hemostatic pattern occurs within the uteroplacental circulation in P-EC compared with normal pregnancy. Much recent research has focused on the epidemiological link between inherited thrombophilia and P-EC. The data suggest a weak statistical association, indicating an improbable primary role in the pathogenesis. Without clear evidence, low molecular weight heparins have been widely used to reduce recurrence of P-EC in thrombophilia-positive women. This practice now should be reviewed. Future research needs to focus on improving our basic scientific understanding of the role of the hemostatic system in human placentation.
Item Type:
Article
Language:
en
MeSH:
Aspirin; Female; Hemostasis; Heparin, Low-Molecular-Weight; Humans; Hypertension, Pregnancy-Induced; Placental Circulation; Placentation; Pre-Eclampsia; Pregnancy; Thrombophilia
ISSN:
1098-9064

Full metadata record

DC FieldValue Language
dc.contributor.authorIsmail, Siti Khadijahen
dc.contributor.authorHiggins, John Ren
dc.date.accessioned2011-07-01T11:25:10Z-
dc.date.available2011-07-01T11:25:10Z-
dc.date.issued2011-03-
dc.identifier.citationHemostasis in pre-eclampsia. 2011, 37 (2):111-7 Semin. Thromb. Hemost.en
dc.identifier.issn1098-9064-
dc.identifier.pmid21370210-
dc.identifier.doi10.1055/s-0030-1270336-
dc.identifier.urihttp://hdl.handle.net/10147/135091-
dc.description.abstractPre-eclampsia (P-EC) is a multisystem disorder exclusive to pregnancy. It complicates ~2 to 8% of all pregnancies and remains a major cause of maternal mortality. P-EC is characterized by a profound hypercoagulable state. The delicate hemostatic balance that must be maintained in the uteroplacental circulation during pregnancy makes this system vulnerable to perturbation. An abnormal hemostatic pattern occurs within the uteroplacental circulation in P-EC compared with normal pregnancy. Much recent research has focused on the epidemiological link between inherited thrombophilia and P-EC. The data suggest a weak statistical association, indicating an improbable primary role in the pathogenesis. Without clear evidence, low molecular weight heparins have been widely used to reduce recurrence of P-EC in thrombophilia-positive women. This practice now should be reviewed. Future research needs to focus on improving our basic scientific understanding of the role of the hemostatic system in human placentation.-
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21370210en
dc.subject.meshAspirin-
dc.subject.meshFemale-
dc.subject.meshHemostasis-
dc.subject.meshHeparin, Low-Molecular-Weight-
dc.subject.meshHumans-
dc.subject.meshHypertension, Pregnancy-Induced-
dc.subject.meshPlacental Circulation-
dc.subject.meshPlacentation-
dc.subject.meshPre-Eclampsia-
dc.subject.meshPregnancy-
dc.subject.meshThrombophilia-
dc.titleHemostasis in pre-eclampsia.en
dc.typeArticleen
dc.contributor.departmentAnu Research Centre, Department of Obstetrics and Gynaecology, University College Cork, Cork University Maternity Hospital, Ireland. k.ismail@ucc.ieen
dc.identifier.journalSeminars in thrombosis and hemostasisen
dc.description.provinceMunster-

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