Preadipocyte factor-1 is associated with metabolic profile in severe obesity.

Hdl Handle:
http://hdl.handle.net/10147/135060
Title:
Preadipocyte factor-1 is associated with metabolic profile in severe obesity.
Authors:
O'Connell, J; Lynch, L; Hogan, A; Cawood, T J; O'Shea, D
Affiliation:
Department of Endocrinology, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland. jeanoco@gmail.com
Citation:
Preadipocyte factor-1 is associated with metabolic profile in severe obesity. 2011, 96 (4):E680-4 J. Clin. Endocrinol. Metab.
Journal:
The Journal of clinical endocrinology and metabolism
Issue Date:
Apr-2011
URI:
http://hdl.handle.net/10147/135060
DOI:
10.1210/jc.2010-2026
PubMed ID:
21252254
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/21252254
Abstract:
Dysfunctional adipose tissue has been proposed as a key pathological process linking obesity and metabolic disease. Preadipocyte factor-1 (Pref-1) has been shown to inhibit differentiation in adipocyte precursor cells and could thereby play a role in determining adipocyte size, adipose tissue functioning, and metabolic profile in obese individuals.; We hypothesized that adipose tissue from metabolically healthy obese (MHO) and matched metabolically unhealthy obese individuals would demonstrate distinct differences in relation to Pref-1 expression, adipocyte size, and inflammatory markers.; This was a cross-sectional study, investigating obese patients undergoing bariatric surgery at a tertiary referral centre. Patients included 12 MHO and 17 age- and body mass index-matched metabolically unhealthy obese individuals. Main Outcome Measures: Pref-1, monocyte chemotactic protein-1, TNF-α, granulocyte colony-stimulating factor, IL-6, and adiponectin levels, macrophage numbers, and adipocyte size were measured in omental and subcutaneous adipose tissue.; The MHO group had a lower level of Pref-1 (per 1000 adipocytes) in both subcutaneous [160 (136-177) versus 194 (153-355); P < 0.05] and omental adipose tissue [102 (32-175) versus 194 (100-350); P < 0.005]. This was associated with lower numbers of macrophages, lower levels of TNF-α, monocyte chemotactic protein-1, and granulocyte colony-stimulating factor, and higher levels of adiponectin. Omental Pref-1 showed strong correlations with adipocyte size (r = 0.67, P < 0.0005) and metabolic and adipokine parameters, including percent fatty liver (r = 0.62, P < 0.005), fasting glucose (r = 0.68, P < 0.0005), triglyceride (r = 0.60, P < 0.005), high-density lipoprotein cholesterol (r = -0.46, P < 0.05), and adiponectin (r = -0.71, P < 0.05).; Adipose tissue in MHO individuals had lower levels of Pref-1, a known inhibitor of preadipocyte differentiation, and a more favorable inflammatory profile. These factors may be key to protecting this subgroup of obese individuals from the adverse metabolic profile associated with excess adiposity.
Item Type:
Article
Language:
en
MeSH:
Adipocytes; Adult; Bariatric Surgery; Case-Control Studies; Cell Count; Cell Size; Cross-Sectional Studies; Female; Health; Humans; Inflammation Mediators; Intercellular Signaling Peptides and Proteins; Macrophages; Male; Membrane Proteins; Metabolome; Middle Aged; Obesity, Morbid; Severity of Illness Index; Young Adult
ISSN:
1945-7197

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Connell, Jen
dc.contributor.authorLynch, Len
dc.contributor.authorHogan, Aen
dc.contributor.authorCawood, T Jen
dc.contributor.authorO'Shea, Den
dc.date.accessioned2011-07-01T14:10:36Z-
dc.date.available2011-07-01T14:10:36Z-
dc.date.issued2011-04-
dc.identifier.citationPreadipocyte factor-1 is associated with metabolic profile in severe obesity. 2011, 96 (4):E680-4 J. Clin. Endocrinol. Metab.en
dc.identifier.issn1945-7197-
dc.identifier.pmid21252254-
dc.identifier.doi10.1210/jc.2010-2026-
dc.identifier.urihttp://hdl.handle.net/10147/135060-
dc.description.abstractDysfunctional adipose tissue has been proposed as a key pathological process linking obesity and metabolic disease. Preadipocyte factor-1 (Pref-1) has been shown to inhibit differentiation in adipocyte precursor cells and could thereby play a role in determining adipocyte size, adipose tissue functioning, and metabolic profile in obese individuals.-
dc.description.abstractWe hypothesized that adipose tissue from metabolically healthy obese (MHO) and matched metabolically unhealthy obese individuals would demonstrate distinct differences in relation to Pref-1 expression, adipocyte size, and inflammatory markers.-
dc.description.abstractThis was a cross-sectional study, investigating obese patients undergoing bariatric surgery at a tertiary referral centre. Patients included 12 MHO and 17 age- and body mass index-matched metabolically unhealthy obese individuals. Main Outcome Measures: Pref-1, monocyte chemotactic protein-1, TNF-α, granulocyte colony-stimulating factor, IL-6, and adiponectin levels, macrophage numbers, and adipocyte size were measured in omental and subcutaneous adipose tissue.-
dc.description.abstractThe MHO group had a lower level of Pref-1 (per 1000 adipocytes) in both subcutaneous [160 (136-177) versus 194 (153-355); P < 0.05] and omental adipose tissue [102 (32-175) versus 194 (100-350); P < 0.005]. This was associated with lower numbers of macrophages, lower levels of TNF-α, monocyte chemotactic protein-1, and granulocyte colony-stimulating factor, and higher levels of adiponectin. Omental Pref-1 showed strong correlations with adipocyte size (r = 0.67, P < 0.0005) and metabolic and adipokine parameters, including percent fatty liver (r = 0.62, P < 0.005), fasting glucose (r = 0.68, P < 0.0005), triglyceride (r = 0.60, P < 0.005), high-density lipoprotein cholesterol (r = -0.46, P < 0.05), and adiponectin (r = -0.71, P < 0.05).-
dc.description.abstractAdipose tissue in MHO individuals had lower levels of Pref-1, a known inhibitor of preadipocyte differentiation, and a more favorable inflammatory profile. These factors may be key to protecting this subgroup of obese individuals from the adverse metabolic profile associated with excess adiposity.-
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21252254en
dc.subject.meshAdipocytes-
dc.subject.meshAdult-
dc.subject.meshBariatric Surgery-
dc.subject.meshCase-Control Studies-
dc.subject.meshCell Count-
dc.subject.meshCell Size-
dc.subject.meshCross-Sectional Studies-
dc.subject.meshFemale-
dc.subject.meshHealth-
dc.subject.meshHumans-
dc.subject.meshInflammation Mediators-
dc.subject.meshIntercellular Signaling Peptides and Proteins-
dc.subject.meshMacrophages-
dc.subject.meshMale-
dc.subject.meshMembrane Proteins-
dc.subject.meshMetabolome-
dc.subject.meshMiddle Aged-
dc.subject.meshObesity, Morbid-
dc.subject.meshSeverity of Illness Index-
dc.subject.meshYoung Adult-
dc.titlePreadipocyte factor-1 is associated with metabolic profile in severe obesity.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland. jeanoco@gmail.comen
dc.identifier.journalThe Journal of clinical endocrinology and metabolismen
dc.description.provinceLeinster-

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