Seasonal variation of serum vitamin D and the effect of vitamin D supplementation in Irish community-dwelling older people.

Hdl Handle:
http://hdl.handle.net/10147/135054
Title:
Seasonal variation of serum vitamin D and the effect of vitamin D supplementation in Irish community-dwelling older people.
Authors:
Romero-Ortuno, Roman; Cogan, Lisa; Browne, Joseph; Healy, Martin; Casey, Miriam Catherine; Cunningham, Conal; Walsh, James Bernard; Kenny, Rose Anne
Affiliation:
Trinity College Dublin-TRIL Clinic, Hospital, St James's Hospital, Dublin 8, Co. Dublin, Ireland. romeror@tcd.ie
Citation:
Seasonal variation of serum vitamin D and the effect of vitamin D supplementation in Irish community-dwelling older people. 2011, 40 (2):168-74 Age Ageing
Journal:
Age and ageing
Issue Date:
Mar-2011
URI:
http://hdl.handle.net/10147/135054
DOI:
10.1093/ageing/afq138
PubMed ID:
21051444
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/21051444
Abstract:
Ireland is at 53°N, and its population risk of vitamin D deficiency is high. Previous Irish studies suggested a significant seasonality of serum 25-hydroxyvitamin D [25(OH)D] and a beneficial effect of supplementation in raising 25(OH)D levels. However, in Irish older people, little is known about the magnitude of the supplementation effect and whether supplementation affects 25(OH)D seasonality.; cross-sectional observational. Setting: outpatient clinic.; five hundred and forty-six community-dwelling subjects (mean age 73.0, SD 7.4; 68.5% females) were assessed between September 2007 and May 2009.; for supplemented and non-supplemented: 'cosinor' analysis (Pulse_XP®) of monthly 25(OH)D. Period global solar radiation (GSR) and solar elevation angle (SEA) data were collected as proxy markers of ultraviolet-B radiation exposure. Multivariate linear regression was conducted to investigate the independent effect of GSR and SEA on 25(OH)D, controlling for confounders.; supplemented group (N = 183): 89.1% were on cholecalciferol 800 IU/day. Mean 25(OH)D = 64.1 (95% confidence interval: 52.2-75.8) nmol/l, with no significant seasonality; regression: neither GSR nor SEA predicted 25(OH)D. Non-supplemented group (N = 363): mean 25(OH)D = 40.3 (35.5-45.0) nmol/l, with significant seasonality (55.5% variance remaining), peak in August, amplitude = 6.0 (3.1-8.8) nmol/l; regression: both GSR (P = 0.002) and the interaction GSR * SEA (P = 0.018) predicted 25(OH)D.; vitamin D supplementation was associated with a mean serum 25(OH)D increase of 23.8 nmol/l. Interestingly, supplementation seemed to blunt seasonality. In the supplemented group, 72.1% had individual 25(OH)D levels below the recommended 75 nmol/l. There is a case for universal supplementation in Irish older people, probably at a higher dose. Further research is needed to establish the optimum dose.
Item Type:
Article
Language:
en
MeSH:
Aged; Aged, 80 and over; Ambulatory Care Facilities; Biological Markers; Cholecalciferol; Cross-Sectional Studies; Dietary Supplements; Female; Geriatric Assessment; Humans; Independent Living; Ireland; Linear Models; Male; Odds Ratio; Risk Assessment; Risk Factors; Seasons; Sunlight; Treatment Outcome; Ultraviolet Rays; Vitamin D; Vitamin D Deficiency
ISSN:
1468-2834

Full metadata record

DC FieldValue Language
dc.contributor.authorRomero-Ortuno, Romanen
dc.contributor.authorCogan, Lisaen
dc.contributor.authorBrowne, Josephen
dc.contributor.authorHealy, Martinen
dc.contributor.authorCasey, Miriam Catherineen
dc.contributor.authorCunningham, Conalen
dc.contributor.authorWalsh, James Bernarden
dc.contributor.authorKenny, Rose Anneen
dc.date.accessioned2011-07-01T10:54:56Z-
dc.date.available2011-07-01T10:54:56Z-
dc.date.issued2011-03-
dc.identifier.citationSeasonal variation of serum vitamin D and the effect of vitamin D supplementation in Irish community-dwelling older people. 2011, 40 (2):168-74 Age Ageingen
dc.identifier.issn1468-2834-
dc.identifier.pmid21051444-
dc.identifier.doi10.1093/ageing/afq138-
dc.identifier.urihttp://hdl.handle.net/10147/135054-
dc.description.abstractIreland is at 53°N, and its population risk of vitamin D deficiency is high. Previous Irish studies suggested a significant seasonality of serum 25-hydroxyvitamin D [25(OH)D] and a beneficial effect of supplementation in raising 25(OH)D levels. However, in Irish older people, little is known about the magnitude of the supplementation effect and whether supplementation affects 25(OH)D seasonality.-
dc.description.abstractcross-sectional observational. Setting: outpatient clinic.-
dc.description.abstractfive hundred and forty-six community-dwelling subjects (mean age 73.0, SD 7.4; 68.5% females) were assessed between September 2007 and May 2009.-
dc.description.abstractfor supplemented and non-supplemented: 'cosinor' analysis (Pulse_XP®) of monthly 25(OH)D. Period global solar radiation (GSR) and solar elevation angle (SEA) data were collected as proxy markers of ultraviolet-B radiation exposure. Multivariate linear regression was conducted to investigate the independent effect of GSR and SEA on 25(OH)D, controlling for confounders.-
dc.description.abstractsupplemented group (N = 183): 89.1% were on cholecalciferol 800 IU/day. Mean 25(OH)D = 64.1 (95% confidence interval: 52.2-75.8) nmol/l, with no significant seasonality; regression: neither GSR nor SEA predicted 25(OH)D. Non-supplemented group (N = 363): mean 25(OH)D = 40.3 (35.5-45.0) nmol/l, with significant seasonality (55.5% variance remaining), peak in August, amplitude = 6.0 (3.1-8.8) nmol/l; regression: both GSR (P = 0.002) and the interaction GSR * SEA (P = 0.018) predicted 25(OH)D.-
dc.description.abstractvitamin D supplementation was associated with a mean serum 25(OH)D increase of 23.8 nmol/l. Interestingly, supplementation seemed to blunt seasonality. In the supplemented group, 72.1% had individual 25(OH)D levels below the recommended 75 nmol/l. There is a case for universal supplementation in Irish older people, probably at a higher dose. Further research is needed to establish the optimum dose.-
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21051444en
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshAmbulatory Care Facilities-
dc.subject.meshBiological Markers-
dc.subject.meshCholecalciferol-
dc.subject.meshCross-Sectional Studies-
dc.subject.meshDietary Supplements-
dc.subject.meshFemale-
dc.subject.meshGeriatric Assessment-
dc.subject.meshHumans-
dc.subject.meshIndependent Living-
dc.subject.meshIreland-
dc.subject.meshLinear Models-
dc.subject.meshMale-
dc.subject.meshOdds Ratio-
dc.subject.meshRisk Assessment-
dc.subject.meshRisk Factors-
dc.subject.meshSeasons-
dc.subject.meshSunlight-
dc.subject.meshTreatment Outcome-
dc.subject.meshUltraviolet Rays-
dc.subject.meshVitamin D-
dc.subject.meshVitamin D Deficiency-
dc.titleSeasonal variation of serum vitamin D and the effect of vitamin D supplementation in Irish community-dwelling older people.en
dc.typeArticleen
dc.contributor.departmentTrinity College Dublin-TRIL Clinic, Hospital, St James's Hospital, Dublin 8, Co. Dublin, Ireland. romeror@tcd.ieen
dc.identifier.journalAge and ageingen
dc.description.provinceLeinster-

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