Early blood glucose profile and neurodevelopmental outcome at two years in neonatal hypoxic-ischaemic encephalopathy.

Hdl Handle:
http://hdl.handle.net/10147/135051
Title:
Early blood glucose profile and neurodevelopmental outcome at two years in neonatal hypoxic-ischaemic encephalopathy.
Authors:
Nadeem, Montasser; Murray, Deirdre M; Boylan, Geraldine B; Dempsey, Eugene M; Ryan, Cornelius A
Affiliation:
Neonatal Intensive Care Unit, Cork University Maternity Hospital, Cork, Ireland.
Citation:
Early blood glucose profile and neurodevelopmental outcome at two years in neonatal hypoxic-ischaemic encephalopathy. 2011, 11:10 BMC Pediatr
Journal:
BMC pediatrics
Issue Date:
Feb-2011
URI:
http://hdl.handle.net/10147/135051
DOI:
10.1186/1471-2431-11-10
PubMed ID:
21294901
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/21294901
Abstract:
To examine the blood glucose profile and the relationship between blood glucose levels and neurodevelopmental outcome in term infants with hypoxic-ischaemic encephalopathy.; Blood glucose values within 72 hours of birth were collected from 52 term infants with hypoxic-ischaemic encephalopathy. Hypoglycaemia [< 46.8 mg/dL (2.6 mmol/L)] and hyperglycaemia [> 150 mg/dL (8.3 mmol/L)] were correlated to neurodevelopmental outcome at 24 months of age.; Four fifths of the 468 blood samples were in the normoglycaemic range (392/468:83.8%). Of the remaining 76 samples, 51.3% were in the hypoglycaemic range and (48.7%) were hyperglycaemic. A quarter of the hypoglycaemic samples (28.2%:11/39) and a third of the hyperglycaemic samples (32.4%:12/37) were recorded within the first 30 minutes of life. Mean (SD) blood glucose values did not differ between infants with normal and abnormal outcomes [4.89(2.28) mmol/L and 5.02(2.35) mmol/L, p value = 0.15] respectively. In term infants with hypoxic-ischaemic encephalopathy, early hypoglycaemia (between 0-6 hours of life) was associated with adverse outcome at 24 months of age [OR = 5.8, CI = 1.04-32)]. On multivariate analysis to adjust for grade of HIE this association was not statistically significant. Late hypoglycaemia (6-72 hours of life) was not associated with abnormal outcome [OR = 0.22, CI (0.04-1.14)]. The occurrence of hyperglycaemia was not associated with adverse outcome.; During the first 72 hours of life, blood glucose profile in infants with hypoxic-ischaemic encephalopathy varies widely despite a management protocol. Early hypoglycaemia (0-6 hours of life) was associated with severe HIE, and thereby; adverse outcome.
Item Type:
Article
Language:
en
MeSH:
Asphyxia Neonatorum; Biological Markers; Birth Weight; Blood Glucose; Brain Damage, Chronic; Female; Follow-Up Studies; Gestational Age; Humans; Hyperglycemia; Hypoglycemia; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant, Newborn; Male; Retrospective Studies; Time Factors; Treatment Outcome
ISSN:
1471-2431

Full metadata record

DC FieldValue Language
dc.contributor.authorNadeem, Montasseren
dc.contributor.authorMurray, Deirdre Men
dc.contributor.authorBoylan, Geraldine Ben
dc.contributor.authorDempsey, Eugene Men
dc.contributor.authorRyan, Cornelius Aen
dc.date.accessioned2011-07-01T10:28:15Z-
dc.date.available2011-07-01T10:28:15Z-
dc.date.issued2011-02-
dc.identifier.citationEarly blood glucose profile and neurodevelopmental outcome at two years in neonatal hypoxic-ischaemic encephalopathy. 2011, 11:10 BMC Pediatren
dc.identifier.issn1471-2431-
dc.identifier.pmid21294901-
dc.identifier.doi10.1186/1471-2431-11-10-
dc.identifier.urihttp://hdl.handle.net/10147/135051-
dc.description.abstractTo examine the blood glucose profile and the relationship between blood glucose levels and neurodevelopmental outcome in term infants with hypoxic-ischaemic encephalopathy.-
dc.description.abstractBlood glucose values within 72 hours of birth were collected from 52 term infants with hypoxic-ischaemic encephalopathy. Hypoglycaemia [< 46.8 mg/dL (2.6 mmol/L)] and hyperglycaemia [> 150 mg/dL (8.3 mmol/L)] were correlated to neurodevelopmental outcome at 24 months of age.-
dc.description.abstractFour fifths of the 468 blood samples were in the normoglycaemic range (392/468:83.8%). Of the remaining 76 samples, 51.3% were in the hypoglycaemic range and (48.7%) were hyperglycaemic. A quarter of the hypoglycaemic samples (28.2%:11/39) and a third of the hyperglycaemic samples (32.4%:12/37) were recorded within the first 30 minutes of life. Mean (SD) blood glucose values did not differ between infants with normal and abnormal outcomes [4.89(2.28) mmol/L and 5.02(2.35) mmol/L, p value = 0.15] respectively. In term infants with hypoxic-ischaemic encephalopathy, early hypoglycaemia (between 0-6 hours of life) was associated with adverse outcome at 24 months of age [OR = 5.8, CI = 1.04-32)]. On multivariate analysis to adjust for grade of HIE this association was not statistically significant. Late hypoglycaemia (6-72 hours of life) was not associated with abnormal outcome [OR = 0.22, CI (0.04-1.14)]. The occurrence of hyperglycaemia was not associated with adverse outcome.-
dc.description.abstractDuring the first 72 hours of life, blood glucose profile in infants with hypoxic-ischaemic encephalopathy varies widely despite a management protocol. Early hypoglycaemia (0-6 hours of life) was associated with severe HIE, and thereby; adverse outcome.-
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21294901en
dc.subject.meshAsphyxia Neonatorum-
dc.subject.meshBiological Markers-
dc.subject.meshBirth Weight-
dc.subject.meshBlood Glucose-
dc.subject.meshBrain Damage, Chronic-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshGestational Age-
dc.subject.meshHumans-
dc.subject.meshHyperglycemia-
dc.subject.meshHypoglycemia-
dc.subject.meshHypothermia, Induced-
dc.subject.meshHypoxia-Ischemia, Brain-
dc.subject.meshInfant, Newborn-
dc.subject.meshMale-
dc.subject.meshRetrospective Studies-
dc.subject.meshTime Factors-
dc.subject.meshTreatment Outcome-
dc.titleEarly blood glucose profile and neurodevelopmental outcome at two years in neonatal hypoxic-ischaemic encephalopathy.en
dc.typeArticleen
dc.contributor.departmentNeonatal Intensive Care Unit, Cork University Maternity Hospital, Cork, Ireland.en
dc.identifier.journalBMC pediatricsen
dc.description.provinceMunster-

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