Candida infection of the central nervous system following neurosurgery: a 12-year review.

Hdl Handle:
http://hdl.handle.net/10147/132542
Title:
Candida infection of the central nervous system following neurosurgery: a 12-year review.
Authors:
O'Brien, Deirdre; Stevens, Niall T; Lim, Chor Hiang; O'Brien, Donncha F; Smyth, Edmond; Fitzpatrick, Fidelma; Humphreys, Hilary
Affiliation:
Department of Clinical Microbiology, Beaumont Hospital, Dublin 9, Ireland, de.obrien@svuh.ie.
Citation:
Candida infection of the central nervous system following neurosurgery: a 12-year review. 2011, 153 (6):1347-50 Acta Neurochir (Wien)
Journal:
Acta neurochirurgica
Issue Date:
Jun-2011
URI:
http://hdl.handle.net/10147/132542
DOI:
10.1007/s00701-011-0990-9
PubMed ID:
21431456
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/21431456
Abstract:
Candida infection of the central nervous system (CNS) following neurosurgery is relatively unusual but is associated with significant morbidity and mortality. We present our experience with this infection in adults and discuss clinical characteristics, treatment options, and outcome.; All episodes of Candida isolated from the central nervous system were identified by searching our laboratory database. Review of the cases was performed by means of a retrospective chart review.; Eleven episodes of Candida CSF infection following neurosurgery were identified over a 12-year period. Candida albicans was the predominant species isolated (n = 8, 73%). All infections were associated with foreign intracranial material, nine with external ventricular drains (82%), one with a ventriculoperitoneal shunt, one with a lumbar drain, and one with Gliadel wafers (1,3-bis [2-chloroethyl]-1-nitrosurea). Fluconazole or liposomal amphotericin B were the most common anti-fungal agents used. The mortality rate identified in our series was 27%.; Candida infection following neurosurgery remains a relatively rare occurrence but one that causes significant mortality. These are complex infections, the management of which benefits from a close liaison between the clinical microbiologist and neurosurgeon. Prompt initiation of antifungal agents and removal of infected devices offers the best hope of a cure.
Item Type:
Article
Language:
en
ISSN:
0942-0940

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Brien, Deirdreen
dc.contributor.authorStevens, Niall Ten
dc.contributor.authorLim, Chor Hiangen
dc.contributor.authorO'Brien, Donncha Fen
dc.contributor.authorSmyth, Edmonden
dc.contributor.authorFitzpatrick, Fidelmaen
dc.contributor.authorHumphreys, Hilaryen
dc.date.accessioned2011-06-03T13:56:06Z-
dc.date.available2011-06-03T13:56:06Z-
dc.date.issued2011-06-
dc.identifier.citationCandida infection of the central nervous system following neurosurgery: a 12-year review. 2011, 153 (6):1347-50 Acta Neurochir (Wien)en
dc.identifier.issn0942-0940-
dc.identifier.pmid21431456-
dc.identifier.doi10.1007/s00701-011-0990-9-
dc.identifier.urihttp://hdl.handle.net/10147/132542-
dc.description.abstractCandida infection of the central nervous system (CNS) following neurosurgery is relatively unusual but is associated with significant morbidity and mortality. We present our experience with this infection in adults and discuss clinical characteristics, treatment options, and outcome.-
dc.description.abstractAll episodes of Candida isolated from the central nervous system were identified by searching our laboratory database. Review of the cases was performed by means of a retrospective chart review.-
dc.description.abstractEleven episodes of Candida CSF infection following neurosurgery were identified over a 12-year period. Candida albicans was the predominant species isolated (n = 8, 73%). All infections were associated with foreign intracranial material, nine with external ventricular drains (82%), one with a ventriculoperitoneal shunt, one with a lumbar drain, and one with Gliadel wafers (1,3-bis [2-chloroethyl]-1-nitrosurea). Fluconazole or liposomal amphotericin B were the most common anti-fungal agents used. The mortality rate identified in our series was 27%.-
dc.description.abstractCandida infection following neurosurgery remains a relatively rare occurrence but one that causes significant mortality. These are complex infections, the management of which benefits from a close liaison between the clinical microbiologist and neurosurgeon. Prompt initiation of antifungal agents and removal of infected devices offers the best hope of a cure.-
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21431456en
dc.titleCandida infection of the central nervous system following neurosurgery: a 12-year review.en
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Microbiology, Beaumont Hospital, Dublin 9, Ireland, de.obrien@svuh.ie.en
dc.identifier.journalActa neurochirurgicaen
dc.description.provinceLeinster-

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