Platelet function testing: methods of assessment and clinical utility.

Hdl Handle:
http://hdl.handle.net/10147/132323
Title:
Platelet function testing: methods of assessment and clinical utility.
Authors:
Mylotte, Darren; Foley, David; Kenny, Dermot
Affiliation:
Department of Cardiology, Beaumont Hospital, Dublin, Ireland. darrenmylotte@rcsi.ie
Citation:
Platelet function testing: methods of assessment and clinical utility. 2011, 9 (1):14-24 Cardiovasc Hematol Agents Med Chem
Journal:
Cardiovascular & hematological agents in medicinal chemistry
Issue Date:
Jan-2011
URI:
http://hdl.handle.net/10147/132323
PubMed ID:
21121898
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/21121898
Abstract:
Platelets play a central role in the regulation of both thrombosis and haemostasis yet tests of platelet function have, until recently, been exclusively used in the diagnosis and management of bleeding disorders. Recent advances have demonstrated the clinical utility of platelet function testing in patients with cardiovascular disease. The ex vivo measurement of response to antiplatelet therapies (aspirin and clopidogrel), by an ever-increasing array of platelet function tests, is with some assays, predictive of adverse clinical events and thus, represents an emerging area of interest for both the clinician and basic scientist. This review article will describe the advantages and disadvantages of the currently available methods of measuring platelet function and discuss both the limitations and emerging data supporting the role of platelet function studies in clinical practice.
Item Type:
Article
Language:
en
MeSH:
Blood Platelets; Flow Cytometry; Humans; Platelet Activation; Platelet Aggregation; Platelet Function Tests; Thrombelastography
ISSN:
1875-6182

Full metadata record

DC FieldValue Language
dc.contributor.authorMylotte, Darrenen
dc.contributor.authorFoley, Daviden
dc.contributor.authorKenny, Dermoten
dc.date.accessioned2011-05-30T15:23:46Z-
dc.date.available2011-05-30T15:23:46Z-
dc.date.issued2011-01-
dc.identifier.citationPlatelet function testing: methods of assessment and clinical utility. 2011, 9 (1):14-24 Cardiovasc Hematol Agents Med Chemen
dc.identifier.issn1875-6182-
dc.identifier.pmid21121898-
dc.identifier.urihttp://hdl.handle.net/10147/132323-
dc.description.abstractPlatelets play a central role in the regulation of both thrombosis and haemostasis yet tests of platelet function have, until recently, been exclusively used in the diagnosis and management of bleeding disorders. Recent advances have demonstrated the clinical utility of platelet function testing in patients with cardiovascular disease. The ex vivo measurement of response to antiplatelet therapies (aspirin and clopidogrel), by an ever-increasing array of platelet function tests, is with some assays, predictive of adverse clinical events and thus, represents an emerging area of interest for both the clinician and basic scientist. This review article will describe the advantages and disadvantages of the currently available methods of measuring platelet function and discuss both the limitations and emerging data supporting the role of platelet function studies in clinical practice.-
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21121898en
dc.subject.meshBlood Platelets-
dc.subject.meshFlow Cytometry-
dc.subject.meshHumans-
dc.subject.meshPlatelet Activation-
dc.subject.meshPlatelet Aggregation-
dc.subject.meshPlatelet Function Tests-
dc.subject.meshThrombelastography-
dc.titlePlatelet function testing: methods of assessment and clinical utility.en
dc.typeArticleen
dc.contributor.departmentDepartment of Cardiology, Beaumont Hospital, Dublin, Ireland. darrenmylotte@rcsi.ieen
dc.identifier.journalCardiovascular & hematological agents in medicinal chemistryen
dc.description.provinceLeinster-

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