Does Impaired Gallbladder Function Contribute to the Development of Barrett's Esophagus and Esophageal Adenocarcinoma?

Hdl Handle:
http://hdl.handle.net/10147/132274
Title:
Does Impaired Gallbladder Function Contribute to the Development of Barrett's Esophagus and Esophageal Adenocarcinoma?
Authors:
Nassr, Ayman O; Gilani, Syeda Nadia Shah; Atie, Mohammed; Abdelhafiz, Tariq; Connolly, Val; Hickey, Neil; Walsh, Thomas Noel
Affiliation:
Department of Surgery, Academic Centre, Connolly Hospital, Blanchardstown, Dublin 15, Ireland.
Citation:
Does Impaired Gallbladder Function Contribute to the Development of Barrett's Esophagus and Esophageal Adenocarcinoma? 2011, 15 (6):908-14 J. Gastrointest. Surg.
Journal:
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
Issue Date:
Jun-2011
URI:
http://hdl.handle.net/10147/132274
DOI:
10.1007/s11605-011-1520-z
PubMed ID:
21484485
Additional Links:
10.1007/s11605-011-1520-z
Abstract:
Esophageal adenocarcinoma is aetiologically associated with gastro-esophageal reflux, but the mechanisms responsible for the metaplasia-dysplasia sequence are unknown. Bile components are implicated. Impaired gallbladder function may contribute to duodenogastric reflux (DGR) and harmful GERD.; This study aims to compare gallbladder function in patients with Barrett's esophagus, adenocarcinoma, and controls.; Three groups of patients, all free of gallstone disease, were studied. Group 1: (n = 15) were normal controls. Group 2: (n = 15) were patients with >3-cm-long segment of Barrett's esophagus. Group 3: (n = 15) were patients with esophageal adenocarcinoma. Using real-time ultrasonography unit, gallbladder volume was measured in subjects following a 10-h fast. Ejection fraction was calculated before and after standard liquid meal and compared between the groups.; The mean percentage reduction in gallbladder volume was 50% at 40 min in the adenocarcinoma group compared with 72.4% in the control group (p < 0.001). At 60 min, gallbladder filling had recommenced in the control group to 64.1% of fasting volume while continuing to empty with further reduction to 63% in the Barrett's group and to 50.6% (p = 0.008) in the adenocarcinoma group. The mean gallbladder ejection fraction decreased progressively from controls to Barrett's to adenocarcinoma and was significantly lower in Barrett's group (60.9%; p = 0.019) and adenocarcinoma group (47.9%; p < 0.001) compared with normal controls (70.9%).; Gallbladder function is progressively impaired in Barrett's esophagus and adenocarcinoma. Gallbladder malfunction increases duodenogastric reflux, exposing the lower esophagus to an altered chemical milieu which, in turn, may have a role in promoting metaplasia-dysplasia-neoplasia sequence in the lower esophageal mucosa.
Item Type:
Article
Language:
en
ISSN:
1873-4626

Full metadata record

DC FieldValue Language
dc.contributor.authorNassr, Ayman Oen
dc.contributor.authorGilani, Syeda Nadia Shahen
dc.contributor.authorAtie, Mohammeden
dc.contributor.authorAbdelhafiz, Tariqen
dc.contributor.authorConnolly, Valen
dc.contributor.authorHickey, Neilen
dc.contributor.authorWalsh, Thomas Noelen
dc.date.accessioned2011-05-27T14:59:44Z-
dc.date.available2011-05-27T14:59:44Z-
dc.date.issued2011-06-
dc.identifier.citationDoes Impaired Gallbladder Function Contribute to the Development of Barrett's Esophagus and Esophageal Adenocarcinoma? 2011, 15 (6):908-14 J. Gastrointest. Surg.en
dc.identifier.issn1873-4626-
dc.identifier.pmid21484485-
dc.identifier.doi10.1007/s11605-011-1520-z-
dc.identifier.urihttp://hdl.handle.net/10147/132274-
dc.description.abstractEsophageal adenocarcinoma is aetiologically associated with gastro-esophageal reflux, but the mechanisms responsible for the metaplasia-dysplasia sequence are unknown. Bile components are implicated. Impaired gallbladder function may contribute to duodenogastric reflux (DGR) and harmful GERD.-
dc.description.abstractThis study aims to compare gallbladder function in patients with Barrett's esophagus, adenocarcinoma, and controls.-
dc.description.abstractThree groups of patients, all free of gallstone disease, were studied. Group 1: (n = 15) were normal controls. Group 2: (n = 15) were patients with >3-cm-long segment of Barrett's esophagus. Group 3: (n = 15) were patients with esophageal adenocarcinoma. Using real-time ultrasonography unit, gallbladder volume was measured in subjects following a 10-h fast. Ejection fraction was calculated before and after standard liquid meal and compared between the groups.-
dc.description.abstractThe mean percentage reduction in gallbladder volume was 50% at 40 min in the adenocarcinoma group compared with 72.4% in the control group (p < 0.001). At 60 min, gallbladder filling had recommenced in the control group to 64.1% of fasting volume while continuing to empty with further reduction to 63% in the Barrett's group and to 50.6% (p = 0.008) in the adenocarcinoma group. The mean gallbladder ejection fraction decreased progressively from controls to Barrett's to adenocarcinoma and was significantly lower in Barrett's group (60.9%; p = 0.019) and adenocarcinoma group (47.9%; p < 0.001) compared with normal controls (70.9%).-
dc.description.abstractGallbladder function is progressively impaired in Barrett's esophagus and adenocarcinoma. Gallbladder malfunction increases duodenogastric reflux, exposing the lower esophagus to an altered chemical milieu which, in turn, may have a role in promoting metaplasia-dysplasia-neoplasia sequence in the lower esophageal mucosa.-
dc.language.isoenen
dc.relation.url10.1007/s11605-011-1520-zen
dc.titleDoes Impaired Gallbladder Function Contribute to the Development of Barrett's Esophagus and Esophageal Adenocarcinoma?en
dc.typeArticleen
dc.contributor.departmentDepartment of Surgery, Academic Centre, Connolly Hospital, Blanchardstown, Dublin 15, Ireland.en
dc.identifier.journalJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tracten
dc.description.provinceLeinster-

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