Toxicity of cetuximab versus cisplatin concurrent with radiotherapy in locally advanced head and neck squamous cell cancer (LAHNSCC).

Hdl Handle:
http://hdl.handle.net/10147/132015
Title:
Toxicity of cetuximab versus cisplatin concurrent with radiotherapy in locally advanced head and neck squamous cell cancer (LAHNSCC).
Authors:
Walsh, Lorraine; Gillham, Charles; Dunne, Mary; Fraser, Ian; Hollywood, Donal; Armstrong, John; Thirion, Pierre
Affiliation:
Department of Radiation Oncology, St. Luke's Hospital, Dublin, Ireland.
Citation:
Toxicity of cetuximab versus cisplatin concurrent with radiotherapy in locally advanced head and neck squamous cell cancer (LAHNSCC). 2011, 98 (1):38-41 Radiother Oncol
Publisher:
Elsevier
Journal:
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Issue Date:
Jan-2011
URI:
http://hdl.handle.net/10147/132015
DOI:
10.1016/j.radonc.2010.11.009
PubMed ID:
21159400
Abstract:
We retrospectively reviewed acute toxicity with cetuximab and radiotherapy, comparing it with a matched cisplatin group. The cetuximab group experienced significantly more toxicity--grade ≥3 oral mucositis (p=0.014), skin dermatitis (p=0.0004), ≥10% weight loss (p=0.03), and enteral feeding requirement (p=0.05). This finding of enhanced toxicity is similar to recent publications.
Item Type:
Article
Language:
en
Description:
We retrospectively reviewed acute toxicity with cetuximab and radiotherapy, comparing it with a matched cisplatin group. The cetuximab group experienced significantly more toxicity--grade ≥3 oral mucositis (p=0.014), skin dermatitis (p=0.0004), ≥10% weight loss (p=0.03), and enteral feeding requirement (p=0.05). This finding of enhanced toxicity is similar to recent publications.
MeSH:
Adult; Aged; Antibodies, Monoclonal; Antineoplastic Agents; Carcinoma; Cisplatin; Combined Modality Therapy; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasms, Squamous Cell; Patient Compliance; Radiotherapy Dosage; Retrospective Studies
ISSN:
1879-0887

Full metadata record

DC FieldValue Language
dc.contributor.authorWalsh, Lorraineen
dc.contributor.authorGillham, Charlesen
dc.contributor.authorDunne, Maryen
dc.contributor.authorFraser, Ianen
dc.contributor.authorHollywood, Donalen
dc.contributor.authorArmstrong, Johnen
dc.contributor.authorThirion, Pierreen
dc.date.accessioned2011-05-25T13:29:52Z-
dc.date.available2011-05-25T13:29:52Z-
dc.date.issued2011-01-
dc.identifier.citationToxicity of cetuximab versus cisplatin concurrent with radiotherapy in locally advanced head and neck squamous cell cancer (LAHNSCC). 2011, 98 (1):38-41 Radiother Oncolen
dc.identifier.issn1879-0887-
dc.identifier.pmid21159400-
dc.identifier.doi10.1016/j.radonc.2010.11.009-
dc.identifier.urihttp://hdl.handle.net/10147/132015-
dc.descriptionWe retrospectively reviewed acute toxicity with cetuximab and radiotherapy, comparing it with a matched cisplatin group. The cetuximab group experienced significantly more toxicity--grade ≥3 oral mucositis (p=0.014), skin dermatitis (p=0.0004), ≥10% weight loss (p=0.03), and enteral feeding requirement (p=0.05). This finding of enhanced toxicity is similar to recent publications.en
dc.description.abstractWe retrospectively reviewed acute toxicity with cetuximab and radiotherapy, comparing it with a matched cisplatin group. The cetuximab group experienced significantly more toxicity--grade ≥3 oral mucositis (p=0.014), skin dermatitis (p=0.0004), ≥10% weight loss (p=0.03), and enteral feeding requirement (p=0.05). This finding of enhanced toxicity is similar to recent publications.-
dc.language.isoenen
dc.publisherElsevieren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAntibodies, Monoclonal-
dc.subject.meshAntineoplastic Agents-
dc.subject.meshCarcinoma-
dc.subject.meshCisplatin-
dc.subject.meshCombined Modality Therapy-
dc.subject.meshFemale-
dc.subject.meshHead and Neck Neoplasms-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasms, Squamous Cell-
dc.subject.meshPatient Compliance-
dc.subject.meshRadiotherapy Dosage-
dc.subject.meshRetrospective Studies-
dc.titleToxicity of cetuximab versus cisplatin concurrent with radiotherapy in locally advanced head and neck squamous cell cancer (LAHNSCC).en
dc.typeArticleen
dc.contributor.departmentDepartment of Radiation Oncology, St. Luke's Hospital, Dublin, Ireland.en
dc.identifier.journalRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncologyen
dc.description.provinceLeinster-

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