A Method for the Prediction of Late Organ-at-Risk Toxicity After Radiotherapy of the Prostate Using Equivalent Uniform Dose.

Hdl Handle:
http://hdl.handle.net/10147/131992
Title:
A Method for the Prediction of Late Organ-at-Risk Toxicity After Radiotherapy of the Prostate Using Equivalent Uniform Dose.
Authors:
Fleming, Cathy; Kelly, Colin; Thirion, Pierre; Fitzpatrick, Kathryn; Armstrong, John
Affiliation:
Clinical Trials Unit, St. Luke's Hospital, Rathgar, Dublin Ireland.
Citation:
A Method for the Prediction of Late Organ-at-Risk Toxicity After Radiotherapy of the Prostate Using Equivalent Uniform Dose. 2011, 80 (2):608-13 Int. J. Radiat. Oncol. Biol. Phys.
Publisher:
Elsevier
Journal:
International journal of radiation oncology, biology, physics
Issue Date:
1-Jun-2011
URI:
http://hdl.handle.net/10147/131992
DOI:
10.1016/j.ijrobp.2010.07.1994
PubMed ID:
20934261
Abstract:
To evaluate the predictive value of equivalent uniform doses (EUD) for late bladder and rectal toxicity after high-dose three-dimensional conformal radiation therapy (3D-CRT) to the prostate.; Using the method developed by Kutcher et al., EUDs for whole bladder and rectum were calculated from the dose-volume histograms of 180 patients with localized prostate cancer treated to 70-74 Gy with 3D-CRT. Late complications were recorded using the Radiation Therapy Oncology Group scale, correlated against EUD and known physical predictive indicators.; EUD is an independent prognostic factor for Grade 2+ long-term rectal and bladder toxicity after radiation treatment to the prostate. Patients receiving an EUD >63.1 Gy to the rectum have a statistically significant (10% vs. 30%; p = 0.002) higher risk of developing Grade 2+ late complications. Patients receiving an EUD >53.4 Gy to the bladder have a statistically significant (10% vs. 33%; p = 0.001) higher risk of developing Grade 2+ late complications.; It has been demonstrated that EUD is a strong independent predictive factor for Grade 2+ late complications after 3D-CRT to the prostate. Threshold values have been demonstrated for both bladder and rectum, above which there is a clinically significant increased risk of complications.
Item Type:
Article
Language:
en
Description:
PURPOSE: To evaluate the predictive value of equivalent uniform doses (EUD) for late bladder and rectal toxicity after high-dose three-dimensional conformal radiation therapy (3D-CRT) to the prostate. MATERIALS AND METHODS: Using the method developed by Kutcher et al., EUDs for whole bladder and rectum were calculated from the dose-volume histograms of 180 patients with localized prostate cancer treated to 70-74 Gy with 3D-CRT. Late complications were recorded using the Radiation Therapy Oncology Group scale, correlated against EUD and known physical predictive indicators. RESULTS: EUD is an independent prognostic factor for Grade 2+ long-term rectal and bladder toxicity after radiation treatment to the prostate. Patients receiving an EUD >63.1 Gy to the rectum have a statistically significant (10% vs. 30%; p = 0.002) higher risk of developing Grade 2+ late complications. Patients receiving an EUD >53.4 Gy to the bladder have a statistically significant (10% vs. 33%; p = 0.001) higher risk of developing Grade 2+ late complications. CONCLUSIONS: It has been demonstrated that EUD is a strong independent predictive factor for Grade 2+ late complications after 3D-CRT to the prostate. Threshold values have been demonstrated for both bladder and rectum, above which there is a clinically significant increased risk of complications.
ISSN:
1879-355X

Full metadata record

DC FieldValue Language
dc.contributor.authorFleming, Cathyen
dc.contributor.authorKelly, Colinen
dc.contributor.authorThirion, Pierreen
dc.contributor.authorFitzpatrick, Kathrynen
dc.contributor.authorArmstrong, Johnen
dc.date.accessioned2011-05-25T13:31:30Z-
dc.date.available2011-05-25T13:31:30Z-
dc.date.issued2011-06-01-
dc.identifier.citationA Method for the Prediction of Late Organ-at-Risk Toxicity After Radiotherapy of the Prostate Using Equivalent Uniform Dose. 2011, 80 (2):608-13 Int. J. Radiat. Oncol. Biol. Phys.en
dc.identifier.issn1879-355X-
dc.identifier.pmid20934261-
dc.identifier.doi10.1016/j.ijrobp.2010.07.1994-
dc.identifier.urihttp://hdl.handle.net/10147/131992-
dc.descriptionPURPOSE: To evaluate the predictive value of equivalent uniform doses (EUD) for late bladder and rectal toxicity after high-dose three-dimensional conformal radiation therapy (3D-CRT) to the prostate. MATERIALS AND METHODS: Using the method developed by Kutcher et al., EUDs for whole bladder and rectum were calculated from the dose-volume histograms of 180 patients with localized prostate cancer treated to 70-74 Gy with 3D-CRT. Late complications were recorded using the Radiation Therapy Oncology Group scale, correlated against EUD and known physical predictive indicators. RESULTS: EUD is an independent prognostic factor for Grade 2+ long-term rectal and bladder toxicity after radiation treatment to the prostate. Patients receiving an EUD >63.1 Gy to the rectum have a statistically significant (10% vs. 30%; p = 0.002) higher risk of developing Grade 2+ late complications. Patients receiving an EUD >53.4 Gy to the bladder have a statistically significant (10% vs. 33%; p = 0.001) higher risk of developing Grade 2+ late complications. CONCLUSIONS: It has been demonstrated that EUD is a strong independent predictive factor for Grade 2+ late complications after 3D-CRT to the prostate. Threshold values have been demonstrated for both bladder and rectum, above which there is a clinically significant increased risk of complications.en
dc.description.abstractTo evaluate the predictive value of equivalent uniform doses (EUD) for late bladder and rectal toxicity after high-dose three-dimensional conformal radiation therapy (3D-CRT) to the prostate.-
dc.description.abstractUsing the method developed by Kutcher et al., EUDs for whole bladder and rectum were calculated from the dose-volume histograms of 180 patients with localized prostate cancer treated to 70-74 Gy with 3D-CRT. Late complications were recorded using the Radiation Therapy Oncology Group scale, correlated against EUD and known physical predictive indicators.-
dc.description.abstractEUD is an independent prognostic factor for Grade 2+ long-term rectal and bladder toxicity after radiation treatment to the prostate. Patients receiving an EUD >63.1 Gy to the rectum have a statistically significant (10% vs. 30%; p = 0.002) higher risk of developing Grade 2+ late complications. Patients receiving an EUD >53.4 Gy to the bladder have a statistically significant (10% vs. 33%; p = 0.001) higher risk of developing Grade 2+ late complications.-
dc.description.abstractIt has been demonstrated that EUD is a strong independent predictive factor for Grade 2+ late complications after 3D-CRT to the prostate. Threshold values have been demonstrated for both bladder and rectum, above which there is a clinically significant increased risk of complications.-
dc.language.isoenen
dc.publisherElsevieren
dc.titleA Method for the Prediction of Late Organ-at-Risk Toxicity After Radiotherapy of the Prostate Using Equivalent Uniform Dose.en
dc.typeArticleen
dc.contributor.departmentClinical Trials Unit, St. Luke's Hospital, Rathgar, Dublin Ireland.en
dc.identifier.journalInternational journal of radiation oncology, biology, physicsen
dc.description.provinceLeinster-

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