Bioluminescent imaging: a critical tool in pre-clinical oncology research.

Hdl Handle:
http://hdl.handle.net/10147/129689
Title:
Bioluminescent imaging: a critical tool in pre-clinical oncology research.
Authors:
O'Neill, Karen; Lyons, Scott K; Gallagher, William M; Curran, Kathleen M; Byrne, Annette T
Affiliation:
UCD School of Medicine and Medical Science, Health Science Building, University College Dublin, Belfield, Dublin 4, Ireland.
Citation:
Bioluminescent imaging: a critical tool in pre-clinical oncology research. 2010, 220 (3):317-27 J. Pathol.
Journal:
The Journal of pathology
Issue Date:
Feb-2010
URI:
http://hdl.handle.net/10147/129689
DOI:
10.1002/path.2656
PubMed ID:
19967724
Abstract:
Bioluminescent imaging (BLI) is a non-invasive imaging modality widely used in the field of pre-clinical oncology research. Imaging of small animal tumour models using BLI involves the generation of light by luciferase-expressing cells in the animal following administration of substrate. This light may be imaged using an external detector. The technique allows a variety of tumour-associated properties to be visualized dynamically in living models. The increasing use of BLI as a small-animal imaging modality has led to advances in the development of xenogeneic, orthotopic, and genetically engineered animal models expressing luciferase genes. This review aims to provide insight into the principles of BLI and its applications in cancer research. Many studies to assess tumour growth and development, as well as efficacy of candidate therapeutics, have been performed using BLI. More recently, advances have also been made using bioluminescent imaging in studies of protein-protein interactions, genetic screening, cell-cycle regulators, and spontaneous cancer development. Such novel studies highlight the versatility and potential of bioluminescent imaging in future oncological research.
Item Type:
Article
Language:
en
MeSH:
Animals; Disease Models, Animal; Disease Progression; Luciferases; Luminescent Measurements; Mice; Neoplasm Metastasis; Neoplasms, Experimental
ISSN:
1096-9896

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Neill, Karenen
dc.contributor.authorLyons, Scott Ken
dc.contributor.authorGallagher, William Men
dc.contributor.authorCurran, Kathleen Men
dc.contributor.authorByrne, Annette Ten
dc.date.accessioned2011-05-17T07:40:13Z-
dc.date.available2011-05-17T07:40:13Z-
dc.date.issued2010-02-
dc.identifier.citationBioluminescent imaging: a critical tool in pre-clinical oncology research. 2010, 220 (3):317-27 J. Pathol.en
dc.identifier.issn1096-9896-
dc.identifier.pmid19967724-
dc.identifier.doi10.1002/path.2656-
dc.identifier.urihttp://hdl.handle.net/10147/129689-
dc.description.abstractBioluminescent imaging (BLI) is a non-invasive imaging modality widely used in the field of pre-clinical oncology research. Imaging of small animal tumour models using BLI involves the generation of light by luciferase-expressing cells in the animal following administration of substrate. This light may be imaged using an external detector. The technique allows a variety of tumour-associated properties to be visualized dynamically in living models. The increasing use of BLI as a small-animal imaging modality has led to advances in the development of xenogeneic, orthotopic, and genetically engineered animal models expressing luciferase genes. This review aims to provide insight into the principles of BLI and its applications in cancer research. Many studies to assess tumour growth and development, as well as efficacy of candidate therapeutics, have been performed using BLI. More recently, advances have also been made using bioluminescent imaging in studies of protein-protein interactions, genetic screening, cell-cycle regulators, and spontaneous cancer development. Such novel studies highlight the versatility and potential of bioluminescent imaging in future oncological research.-
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshDisease Models, Animal-
dc.subject.meshDisease Progression-
dc.subject.meshLuciferases-
dc.subject.meshLuminescent Measurements-
dc.subject.meshMice-
dc.subject.meshNeoplasm Metastasis-
dc.subject.meshNeoplasms, Experimental-
dc.titleBioluminescent imaging: a critical tool in pre-clinical oncology research.en
dc.typeArticleen
dc.contributor.departmentUCD School of Medicine and Medical Science, Health Science Building, University College Dublin, Belfield, Dublin 4, Ireland.en
dc.identifier.journalThe Journal of pathologyen

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