Applying DTI white matter orientations to finite element head models to examine diffuse TBI under high rotational accelerations.

Hdl Handle:
http://hdl.handle.net/10147/129571
Title:
Applying DTI white matter orientations to finite element head models to examine diffuse TBI under high rotational accelerations.
Authors:
Colgan, Niall C; Gilchrist, Michael D; Curran, Kathleen M
Affiliation:
Diagnostic Imaging, University College Dublin, Belfield D4, Ireland. kathleen.curran@ucd.ie
Citation:
Applying DTI white matter orientations to finite element head models to examine diffuse TBI under high rotational accelerations. 2010, 103 (2-3):304-9 Prog. Biophys. Mol. Biol.
Journal:
Progress in biophysics and molecular biology
Issue Date:
Dec-2010
URI:
http://hdl.handle.net/10147/129571
DOI:
10.1016/j.pbiomolbio.2010.09.008
PubMed ID:
20869383
Abstract:
The in-vivo mechanical response of neural tissue during impact loading of the head is simulated using geometrically accurate finite element (FE) head models. However, current FE models do not account for the anisotropic elastic material behaviour of brain tissue. In soft biological tissue, there is a correlation between internal microscopic structure and macroscopic mechanical properties. Therefore, constitutive equations are important for the numerical analysis of the soft biological tissues. By exploiting diffusion tensor techniques the anisotropic orientation of neural tissue is incorporated into a non-linear viscoelastic material model for brain tissue and implemented in an explicit FE analysis. The viscoelastic material parameters are derived from published data and the viscoelastic model is used to describe the mechanical response of brain tissue. The model is formulated in terms of a large strain viscoelastic framework and considers non-linear viscous deformations in combination with non-linear elastic behaviour. The constitutive model was applied in the University College Dublin brain trauma model (UCDBTM) (i.e. three-dimensional finite element head model) to predict the mechanical response of the intra-cranial contents due to rotational injury.
Item Type:
Article
Language:
en
MeSH:
Acceleration; Anisotropy; Brain Injuries; Diffusion Tensor Imaging; Elastic Modulus; Finite Element Analysis; Head; Humans; Models, Biological; Nonlinear Dynamics; Rotation; Trauma Severity Indices; Viscosity
ISSN:
1873-1732

Full metadata record

DC FieldValue Language
dc.contributor.authorColgan, Niall Cen
dc.contributor.authorGilchrist, Michael Den
dc.contributor.authorCurran, Kathleen Men
dc.date.accessioned2011-05-16T08:41:20Z-
dc.date.available2011-05-16T08:41:20Z-
dc.date.issued2010-12-
dc.identifier.citationApplying DTI white matter orientations to finite element head models to examine diffuse TBI under high rotational accelerations. 2010, 103 (2-3):304-9 Prog. Biophys. Mol. Biol.en
dc.identifier.issn1873-1732-
dc.identifier.pmid20869383-
dc.identifier.doi10.1016/j.pbiomolbio.2010.09.008-
dc.identifier.urihttp://hdl.handle.net/10147/129571-
dc.description.abstractThe in-vivo mechanical response of neural tissue during impact loading of the head is simulated using geometrically accurate finite element (FE) head models. However, current FE models do not account for the anisotropic elastic material behaviour of brain tissue. In soft biological tissue, there is a correlation between internal microscopic structure and macroscopic mechanical properties. Therefore, constitutive equations are important for the numerical analysis of the soft biological tissues. By exploiting diffusion tensor techniques the anisotropic orientation of neural tissue is incorporated into a non-linear viscoelastic material model for brain tissue and implemented in an explicit FE analysis. The viscoelastic material parameters are derived from published data and the viscoelastic model is used to describe the mechanical response of brain tissue. The model is formulated in terms of a large strain viscoelastic framework and considers non-linear viscous deformations in combination with non-linear elastic behaviour. The constitutive model was applied in the University College Dublin brain trauma model (UCDBTM) (i.e. three-dimensional finite element head model) to predict the mechanical response of the intra-cranial contents due to rotational injury.-
dc.language.isoenen
dc.subject.meshAcceleration-
dc.subject.meshAnisotropy-
dc.subject.meshBrain Injuries-
dc.subject.meshDiffusion Tensor Imaging-
dc.subject.meshElastic Modulus-
dc.subject.meshFinite Element Analysis-
dc.subject.meshHead-
dc.subject.meshHumans-
dc.subject.meshModels, Biological-
dc.subject.meshNonlinear Dynamics-
dc.subject.meshRotation-
dc.subject.meshTrauma Severity Indices-
dc.subject.meshViscosity-
dc.titleApplying DTI white matter orientations to finite element head models to examine diffuse TBI under high rotational accelerations.en
dc.typeArticleen
dc.contributor.departmentDiagnostic Imaging, University College Dublin, Belfield D4, Ireland. kathleen.curran@ucd.ieen
dc.identifier.journalProgress in biophysics and molecular biologyen

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