Obstructive sleep apnea in chronic obstructive pulmonary disease patients.

Hdl Handle:
http://hdl.handle.net/10147/129397
Title:
Obstructive sleep apnea in chronic obstructive pulmonary disease patients.
Authors:
Lee, Ruth; McNicholas, Walter T
Affiliation:
Pulmonary and Sleep Disorders Unit, St. Vincent's University Hospital, Dublin, Ireland.
Citation:
Obstructive sleep apnea in chronic obstructive pulmonary disease patients. 2011, 17 (2):79-83 Curr Opin Pulm Med
Journal:
Current opinion in pulmonary medicine
Issue Date:
Mar-2011
URI:
http://hdl.handle.net/10147/129397
DOI:
10.1097/MCP.0b013e32834317bb
PubMed ID:
21169840
Abstract:
Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) represent two of the most prevalent chronic respiratory disorders and cardiovascular diseases are major co-morbidities in both. Co-existence of both disorders (overlap syndrome) occurs in 1% of adults and overlap patients have worse nocturnal hypoxemia and hypercapnia than COPD and OSA patients alone. The present review discusses recent data concerning the pathophysiological and clinical significance of the overlap syndrome.; The severity of obstructive ventilatory impairment and hyperinflation, especially the inspiratory capacity to total lung capacity (TLC) ratio, correlates with the severity of sleep-related breathing disturbances. Early treatment with continuous positive airway pressure (CPAP) improves survival, reduces hospitalization and pulmonary hypertension, and also reduces hypoxemia. Evidence of systemic inflammation and oxidative stress in COPD and sleep apnea provides insight into potential interactions between both disorders that may predispose to cardiovascular disease. Long-term outcome studies of overlap patients currently underway should provide further evidence of the clinical significance of the overlap syndrome.; Studies of overlap syndrome patients at a clinical, physiological and molecular level should provide insight into disease mechanisms and consequences of COPD and sleep apnea, in addition to identifying potential relationships with cardiovascular disease.
Item Type:
Article
Language:
en
MeSH:
Anoxia; Cardiovascular Diseases; Comorbidity; Humans; Hypercapnia; Inflammation; Oxidative Stress; Prevalence; Pulmonary Disease, Chronic Obstructive; Sleep Apnea, Obstructive; Syndrome
ISSN:
1531-6971

Full metadata record

DC FieldValue Language
dc.contributor.authorLee, Ruthen
dc.contributor.authorMcNicholas, Walter Ten
dc.date.accessioned2011-05-11T11:55:55Z-
dc.date.available2011-05-11T11:55:55Z-
dc.date.issued2011-03-
dc.identifier.citationObstructive sleep apnea in chronic obstructive pulmonary disease patients. 2011, 17 (2):79-83 Curr Opin Pulm Meden
dc.identifier.issn1531-6971-
dc.identifier.pmid21169840-
dc.identifier.doi10.1097/MCP.0b013e32834317bb-
dc.identifier.urihttp://hdl.handle.net/10147/129397-
dc.description.abstractChronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) represent two of the most prevalent chronic respiratory disorders and cardiovascular diseases are major co-morbidities in both. Co-existence of both disorders (overlap syndrome) occurs in 1% of adults and overlap patients have worse nocturnal hypoxemia and hypercapnia than COPD and OSA patients alone. The present review discusses recent data concerning the pathophysiological and clinical significance of the overlap syndrome.-
dc.description.abstractThe severity of obstructive ventilatory impairment and hyperinflation, especially the inspiratory capacity to total lung capacity (TLC) ratio, correlates with the severity of sleep-related breathing disturbances. Early treatment with continuous positive airway pressure (CPAP) improves survival, reduces hospitalization and pulmonary hypertension, and also reduces hypoxemia. Evidence of systemic inflammation and oxidative stress in COPD and sleep apnea provides insight into potential interactions between both disorders that may predispose to cardiovascular disease. Long-term outcome studies of overlap patients currently underway should provide further evidence of the clinical significance of the overlap syndrome.-
dc.description.abstractStudies of overlap syndrome patients at a clinical, physiological and molecular level should provide insight into disease mechanisms and consequences of COPD and sleep apnea, in addition to identifying potential relationships with cardiovascular disease.-
dc.language.isoenen
dc.subject.meshAnoxia-
dc.subject.meshCardiovascular Diseases-
dc.subject.meshComorbidity-
dc.subject.meshHumans-
dc.subject.meshHypercapnia-
dc.subject.meshInflammation-
dc.subject.meshOxidative Stress-
dc.subject.meshPrevalence-
dc.subject.meshPulmonary Disease, Chronic Obstructive-
dc.subject.meshSleep Apnea, Obstructive-
dc.subject.meshSyndrome-
dc.titleObstructive sleep apnea in chronic obstructive pulmonary disease patients.en
dc.typeArticleen
dc.contributor.departmentPulmonary and Sleep Disorders Unit, St. Vincent's University Hospital, Dublin, Ireland.en
dc.identifier.journalCurrent opinion in pulmonary medicineen
dc.description.provinceLeinster-

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