Anxiety and behavioural disturbance as markers of prodromal Alzheimer's disease in patients with mild cognitive impairment.

Hdl Handle:
http://hdl.handle.net/10147/129395
Title:
Anxiety and behavioural disturbance as markers of prodromal Alzheimer's disease in patients with mild cognitive impairment.
Authors:
Gallagher, Damien; Coen, Robert; Kilroy, Dana; Belinski, Kate; Bruce, Irene; Coakley, Davis; Walsh, Bernard; Cunningham, Conal; Lawlor, Brian A
Affiliation:
Mercer's Institute for Research on Ageing, St. James's Hospital, Dublin, Ireland. gallagherdamien@hotmail.com
Citation:
Anxiety and behavioural disturbance as markers of prodromal Alzheimer's disease in patients with mild cognitive impairment. 2011, 26 (2):166-72 Int J Geriatr Psychiatry
Journal:
International journal of geriatric psychiatry
Issue Date:
Feb-2011
URI:
http://hdl.handle.net/10147/129395
DOI:
10.1002/gps.2509
PubMed ID:
21229599
Abstract:
Depression and anxiety have been reported to be independently predictive of conversion to Alzheimer's disease (AD) in patients with mild cognitive impairment (MCI). Anxiety symptoms have been less well studied and findings in this regard have been inconsistent. The objectives of this study are to determine which symptoms among a range of neuropsychiatric symptoms known to commonly occur in patients with MCI are predictive of later conversion to AD. We also wish to determine whether these symptoms track existing measures of declining cognitive and functional status or may be considered distinct and sensitive biomarkers of evolving Alzheimer's pathology.; One hundred and sixty-one patients with MCI were identified from consecutive referrals to a memory clinic. Univariate, multivariate and cox regression analyses were conducted.; Seventy-six per cent of all patients had at least one neuropsychiatric symptom at baseline of which anxiety (52%), affective disturbance (37%) and aggression (32%) were the most common. Increasing symptom frequency was observed with increasing clinical severity. Anticipatory anxiety and activity disturbances were significantly associated with earlier conversion to AD although this association did not remain significant following adjustment for cognitive status at baseline.; Neuropsychiatric symptoms and anxiety symptoms in particular are common in patients with MCI. In this sample anxiety for upcoming events and purposeless activity frequently co-occurred and were significant clinical predictors of earlier conversion to AD. However, these findings were not independent of cognitive status at baseline and therefore may be markers of severity rather than independent predictors of disease progression.
Item Type:
Article
Language:
en
MeSH:
Aged; Aged, 80 and over; Alzheimer Disease; Anxiety; Behavioral Symptoms; Cognition Disorders; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Predictive Value of Tests; Severity of Illness Index
ISSN:
1099-1166

Full metadata record

DC FieldValue Language
dc.contributor.authorGallagher, Damienen
dc.contributor.authorCoen, Roberten
dc.contributor.authorKilroy, Danaen
dc.contributor.authorBelinski, Kateen
dc.contributor.authorBruce, Ireneen
dc.contributor.authorCoakley, Davisen
dc.contributor.authorWalsh, Bernarden
dc.contributor.authorCunningham, Conalen
dc.contributor.authorLawlor, Brian Aen
dc.date.accessioned2011-05-11T11:14:48Z-
dc.date.available2011-05-11T11:14:48Z-
dc.date.issued2011-02-
dc.identifier.citationAnxiety and behavioural disturbance as markers of prodromal Alzheimer's disease in patients with mild cognitive impairment. 2011, 26 (2):166-72 Int J Geriatr Psychiatryen
dc.identifier.issn1099-1166-
dc.identifier.pmid21229599-
dc.identifier.doi10.1002/gps.2509-
dc.identifier.urihttp://hdl.handle.net/10147/129395-
dc.description.abstractDepression and anxiety have been reported to be independently predictive of conversion to Alzheimer's disease (AD) in patients with mild cognitive impairment (MCI). Anxiety symptoms have been less well studied and findings in this regard have been inconsistent. The objectives of this study are to determine which symptoms among a range of neuropsychiatric symptoms known to commonly occur in patients with MCI are predictive of later conversion to AD. We also wish to determine whether these symptoms track existing measures of declining cognitive and functional status or may be considered distinct and sensitive biomarkers of evolving Alzheimer's pathology.-
dc.description.abstractOne hundred and sixty-one patients with MCI were identified from consecutive referrals to a memory clinic. Univariate, multivariate and cox regression analyses were conducted.-
dc.description.abstractSeventy-six per cent of all patients had at least one neuropsychiatric symptom at baseline of which anxiety (52%), affective disturbance (37%) and aggression (32%) were the most common. Increasing symptom frequency was observed with increasing clinical severity. Anticipatory anxiety and activity disturbances were significantly associated with earlier conversion to AD although this association did not remain significant following adjustment for cognitive status at baseline.-
dc.description.abstractNeuropsychiatric symptoms and anxiety symptoms in particular are common in patients with MCI. In this sample anxiety for upcoming events and purposeless activity frequently co-occurred and were significant clinical predictors of earlier conversion to AD. However, these findings were not independent of cognitive status at baseline and therefore may be markers of severity rather than independent predictors of disease progression.-
dc.language.isoenen
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshAlzheimer Disease-
dc.subject.meshAnxiety-
dc.subject.meshBehavioral Symptoms-
dc.subject.meshCognition Disorders-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeuropsychological Tests-
dc.subject.meshPredictive Value of Tests-
dc.subject.meshSeverity of Illness Index-
dc.titleAnxiety and behavioural disturbance as markers of prodromal Alzheimer's disease in patients with mild cognitive impairment.en
dc.typeArticleen
dc.contributor.departmentMercer's Institute for Research on Ageing, St. James's Hospital, Dublin, Ireland. gallagherdamien@hotmail.comen
dc.identifier.journalInternational journal of geriatric psychiatryen
dc.description.provinceLeinster-

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