Affiliation
Centre for Scientific Computing and Complex Systems Modeling, Dublin City University, Dublin, Ireland. kaghavan@computing.dcu.ieIssue Date
2010-11MeSH
AcetylationAlgorithms
Computational Biology
DNA Methylation
Epigenesis, Genetic
Epigenomics
Histones
Humans
Methylation
Models, Genetic
Phosphorylation
Protein Processing, Post-Translational
Transcription, Genetic
Metadata
Show full item recordCitation
Computational micromodel for epigenetic mechanisms. 2010, 5 (11):e14031 PLoS ONEPublisher
PLosOneJournal
PloS oneDOI
10.1371/journal.pone.0014031PubMed ID
21152421Abstract
Characterization of the epigenetic profile of humans since the initial breakthrough on the human genome project has strongly established the key role of histone modifications and DNA methylation. These dynamic elements interact to determine the normal level of expression or methylation status of the constituent genes in the genome. Recently, considerable evidence has been put forward to demonstrate that environmental stress implicitly alters epigenetic patterns causing imbalance that can lead to cancer initiation. This chain of consequences has motivated attempts to computationally model the influence of histone modification and DNA methylation in gene expression and investigate their intrinsic interdependency. In this paper, we explore the relation between DNA methylation and transcription and characterize in detail the histone modifications for specific DNA methylation levels using a stochastic approach.Item Type
ArticleLanguage
enISSN
1932-6203ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0014031