Platelet reactivity and pregnancy loss.

Hdl Handle:
http://hdl.handle.net/10147/128797
Title:
Platelet reactivity and pregnancy loss.
Authors:
Flood, Karen; Peace, Aaron; Kent, Etaoin; Tedesco, Tony; Dicker, Patrick; Geary, Michael; Malone, Fergal D; Kenny, Dermot
Affiliation:
Department of Obstetrics and Gynaecology, Royal College of Surgeons in Ireland, Dublin, Ireland.
Citation:
Platelet reactivity and pregnancy loss. 2010, 203 (3):281.e1-5 Am. J. Obstet. Gynecol.
Journal:
American journal of obstetrics and gynecology
Issue Date:
Sep-2010
URI:
http://hdl.handle.net/10147/128797
DOI:
10.1016/j.ajog.2010.06.023
PubMed ID:
20684942
Additional Links:
doi:10.1016/j.ajog.2010.06.023
Abstract:
We sought to critically evaluate platelet function in recurrent miscarriage (RM).; We conducted a prospective study comparing 30 patients with unexplained recurrent first-trimester pregnancy loss with 30 control subjects matched for age and serum progesterone level. Platelet function was determined using a modified assay of light transmission aggregometry with multiple agonists at different concentrations. Dose-response curves were created and half-maximal effective concentration values were calculated.; At test completion the half-maximal effective concentration values for arachidonic acid in the patients with RM were significantly less than in the control subjects (0.153 vs 0.230; P = .0099). The dose-response curves were tightly matched for the other agonists.; This novel measurement of platelet function has demonstrated that patients with unexplained RM have significantly increased platelet aggregation in response to arachidonic acid. The enhanced response to this agonist provides an empirical rationale for the use of aspirin in management of this clinical condition.
Item Type:
Article
Language:
en
MeSH:
Abortion, Habitual; Adenosine Diphosphate; Adult; Arachidonic Acid; Case-Control Studies; Collagen Type I; Dose-Response Relationship, Drug; Epinephrine; Female; Humans; Middle Aged; Peptide Fragments; Platelet Aggregation; Platelet Function Tests; Pregnancy; Pregnancy Trimester, First; Prospective Studies
ISSN:
1097-6868

Full metadata record

DC FieldValue Language
dc.contributor.authorFlood, Karenen
dc.contributor.authorPeace, Aaronen
dc.contributor.authorKent, Etaoinen
dc.contributor.authorTedesco, Tonyen
dc.contributor.authorDicker, Patricken
dc.contributor.authorGeary, Michaelen
dc.contributor.authorMalone, Fergal Den
dc.contributor.authorKenny, Dermoten
dc.date.accessioned2011-04-27T15:05:05Z-
dc.date.available2011-04-27T15:05:05Z-
dc.date.issued2010-09-
dc.identifier.citationPlatelet reactivity and pregnancy loss. 2010, 203 (3):281.e1-5 Am. J. Obstet. Gynecol.en
dc.identifier.issn1097-6868-
dc.identifier.pmid20684942-
dc.identifier.doi10.1016/j.ajog.2010.06.023-
dc.identifier.urihttp://hdl.handle.net/10147/128797-
dc.description.abstractWe sought to critically evaluate platelet function in recurrent miscarriage (RM).-
dc.description.abstractWe conducted a prospective study comparing 30 patients with unexplained recurrent first-trimester pregnancy loss with 30 control subjects matched for age and serum progesterone level. Platelet function was determined using a modified assay of light transmission aggregometry with multiple agonists at different concentrations. Dose-response curves were created and half-maximal effective concentration values were calculated.-
dc.description.abstractAt test completion the half-maximal effective concentration values for arachidonic acid in the patients with RM were significantly less than in the control subjects (0.153 vs 0.230; P = .0099). The dose-response curves were tightly matched for the other agonists.-
dc.description.abstractThis novel measurement of platelet function has demonstrated that patients with unexplained RM have significantly increased platelet aggregation in response to arachidonic acid. The enhanced response to this agonist provides an empirical rationale for the use of aspirin in management of this clinical condition.-
dc.language.isoenen
dc.relation.urldoi:10.1016/j.ajog.2010.06.023en
dc.subject.meshAbortion, Habitual-
dc.subject.meshAdenosine Diphosphate-
dc.subject.meshAdult-
dc.subject.meshArachidonic Acid-
dc.subject.meshCase-Control Studies-
dc.subject.meshCollagen Type I-
dc.subject.meshDose-Response Relationship, Drug-
dc.subject.meshEpinephrine-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMiddle Aged-
dc.subject.meshPeptide Fragments-
dc.subject.meshPlatelet Aggregation-
dc.subject.meshPlatelet Function Tests-
dc.subject.meshPregnancy-
dc.subject.meshPregnancy Trimester, First-
dc.subject.meshProspective Studies-
dc.titlePlatelet reactivity and pregnancy loss.en
dc.typeArticleen
dc.contributor.departmentDepartment of Obstetrics and Gynaecology, Royal College of Surgeons in Ireland, Dublin, Ireland.en
dc.identifier.journalAmerican journal of obstetrics and gynecologyen
dc.description.provinceLeinster-

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