Structural MRI correlates for vulnerability and resilience to major depressive disorder.

Hdl Handle:
http://hdl.handle.net/10147/128770
Title:
Structural MRI correlates for vulnerability and resilience to major depressive disorder.
Authors:
Amico, Francesco; Meisenzahl, Eva; Koutsouleris, Nicolaos; Reiser, Maximilian; Möller, Hans-Juergen; Frodl, Thomas
Affiliation:
Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Integrated Neuroimaging, Trinity Academic Medical Centre (The Adelaide and Meath Hospital, incorporating the National Children's Hospital and St. James's Hospital), Trinity College, Dublin, Ireland.
Citation:
Structural MRI correlates for vulnerability and resilience to major depressive disorder. 2011, 36 (1):15-22 J Psychiatry Neurosci
Journal:
Journal of psychiatry & neuroscience : JPN
Issue Date:
Jan-2011
URI:
http://hdl.handle.net/10147/128770
DOI:
10.1503/jpn.090186
PubMed ID:
20964952
Abstract:
In major depressive disorder (MDD), it is unclear to what extent structural brain changes are associated with depressive episodes or represent part of the mechanism by which the risk for illness is mediated. The aim of this study was to investigate whether structural abnormalities are related to risk for the development of MDD.; We compared healthy controls with a positive family history for MDD (HC-FHP), healthy controls with no family history of any psychiatric disease (HC-FHN) and patients with MDD. Groups were age- and sex-matched. We analyzed data from high-resolution magnetic resonance imaging using voxel-based morphometry. We performed small volume corrections for our regions of interest (hippocampus, dorsolateral [DLPFC] and dorsomedial prefrontal cortex [DMPFC], anterior cingulate cortex [ACC] and basal ganglia) using a family-wise error correction (p < 0.05) to control for multiple comparisons.; There were 30 participants in the HC-FHP group, 64 in the HC-FHN group and 33 patients with MDD. The HC-FHP group had smaller right hippocampal and DLPFC grey matter volumes compared with the HC-FHN group, and even smaller right hippocampal volumes compared with patients with MDD. In addition, the HC-FHP group exhibited smaller white matter volumes in the DLPFC and left putamen but also greater volumes in 2 areas of the DMPFC compared with the HC-FHN group. Patients with MDD exhibited smaller volumes in the ACC, DMPFC, DLPFC and the basal ganglia compared with healthy controls.; The retrospective identification of family history might result in a bias toward unidentified participants in the control group at risk for MDD, diminishing the effect size.; Volume reductions in the hippocampus and DLPFC might be associated with a greater risk for MDD. The HC-FHP group had smaller hippocampal volumes compared with patients with MDD, which is suggestive for neuroplastic effects of treatment. The HC-FHP group had not yet experienced a depressive episode and therefore might have been resilient and might have had some protective strategies. Whether resilience is associated with the larger white matter volumes in the DMPFC (e.g., owing to compensatory, neuroplastic remodelling mechanisms) needs to be confirmed in future studies.
Item Type:
Article
Language:
en
MeSH:
Adult; Atrophy; Basal Ganglia; Brain Mapping; Depressive Disorder, Major; Family Health; Female; Gyrus Cinguli; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Prefrontal Cortex; Resilience, Psychological
ISSN:
1488-2434

Full metadata record

DC FieldValue Language
dc.contributor.authorAmico, Francescoen
dc.contributor.authorMeisenzahl, Evaen
dc.contributor.authorKoutsouleris, Nicolaosen
dc.contributor.authorReiser, Maximilianen
dc.contributor.authorMöller, Hans-Juergenen
dc.contributor.authorFrodl, Thomasen
dc.date.accessioned2011-04-27T11:48:15Z-
dc.date.available2011-04-27T11:48:15Z-
dc.date.issued2011-01-
dc.identifier.citationStructural MRI correlates for vulnerability and resilience to major depressive disorder. 2011, 36 (1):15-22 J Psychiatry Neuroscien
dc.identifier.issn1488-2434-
dc.identifier.pmid20964952-
dc.identifier.doi10.1503/jpn.090186-
dc.identifier.urihttp://hdl.handle.net/10147/128770-
dc.description.abstractIn major depressive disorder (MDD), it is unclear to what extent structural brain changes are associated with depressive episodes or represent part of the mechanism by which the risk for illness is mediated. The aim of this study was to investigate whether structural abnormalities are related to risk for the development of MDD.-
dc.description.abstractWe compared healthy controls with a positive family history for MDD (HC-FHP), healthy controls with no family history of any psychiatric disease (HC-FHN) and patients with MDD. Groups were age- and sex-matched. We analyzed data from high-resolution magnetic resonance imaging using voxel-based morphometry. We performed small volume corrections for our regions of interest (hippocampus, dorsolateral [DLPFC] and dorsomedial prefrontal cortex [DMPFC], anterior cingulate cortex [ACC] and basal ganglia) using a family-wise error correction (p < 0.05) to control for multiple comparisons.-
dc.description.abstractThere were 30 participants in the HC-FHP group, 64 in the HC-FHN group and 33 patients with MDD. The HC-FHP group had smaller right hippocampal and DLPFC grey matter volumes compared with the HC-FHN group, and even smaller right hippocampal volumes compared with patients with MDD. In addition, the HC-FHP group exhibited smaller white matter volumes in the DLPFC and left putamen but also greater volumes in 2 areas of the DMPFC compared with the HC-FHN group. Patients with MDD exhibited smaller volumes in the ACC, DMPFC, DLPFC and the basal ganglia compared with healthy controls.-
dc.description.abstractThe retrospective identification of family history might result in a bias toward unidentified participants in the control group at risk for MDD, diminishing the effect size.-
dc.description.abstractVolume reductions in the hippocampus and DLPFC might be associated with a greater risk for MDD. The HC-FHP group had smaller hippocampal volumes compared with patients with MDD, which is suggestive for neuroplastic effects of treatment. The HC-FHP group had not yet experienced a depressive episode and therefore might have been resilient and might have had some protective strategies. Whether resilience is associated with the larger white matter volumes in the DMPFC (e.g., owing to compensatory, neuroplastic remodelling mechanisms) needs to be confirmed in future studies.-
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshAtrophy-
dc.subject.meshBasal Ganglia-
dc.subject.meshBrain Mapping-
dc.subject.meshDepressive Disorder, Major-
dc.subject.meshFamily Health-
dc.subject.meshFemale-
dc.subject.meshGyrus Cinguli-
dc.subject.meshHippocampus-
dc.subject.meshHumans-
dc.subject.meshMagnetic Resonance Imaging-
dc.subject.meshMale-
dc.subject.meshNerve Fibers, Myelinated-
dc.subject.meshNerve Fibers, Unmyelinated-
dc.subject.meshPrefrontal Cortex-
dc.subject.meshResilience, Psychological-
dc.titleStructural MRI correlates for vulnerability and resilience to major depressive disorder.en
dc.typeArticleen
dc.contributor.departmentDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Integrated Neuroimaging, Trinity Academic Medical Centre (The Adelaide and Meath Hospital, incorporating the National Children's Hospital and St. James's Hospital), Trinity College, Dublin, Ireland.en
dc.identifier.journalJournal of psychiatry & neuroscience : JPNen
dc.description.provinceLeinster-

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