Selective deficits in semantic verbal fluency in patients with a first affective episode with psychotic symptoms and a positive history of mania.

Hdl Handle:
http://hdl.handle.net/10147/128758
Title:
Selective deficits in semantic verbal fluency in patients with a first affective episode with psychotic symptoms and a positive history of mania.
Authors:
Kravariti, Eugenia; Reichenberg, Abraham; Morgan, Kevin; Dazzan, Paola; Morgan, Craig; Zanelli, Jolanta W; Lappin, Julia M; Doody, Gillian A; Harrison, Glynn; Jones, Peter B; Murray, Robin M; Fearon, Paul
Affiliation:
Department of Psychiatry, NIHR Biomedical Research Centre, Maudsley NHS Foundation Trust/Institute of Psychiatry, King's College London, Box 58, De Crespigny Park, London SE5 8AF, UK. e.kravariti@iop.kcl.ac.uk
Citation:
Selective deficits in semantic verbal fluency in patients with a first affective episode with psychotic symptoms and a positive history of mania. 2009, 11 (3):323-9 Bipolar Disord
Journal:
Bipolar disorders
Issue Date:
May-2009
URI:
http://hdl.handle.net/10147/128758
DOI:
10.1111/j.1399-5618.2009.00673.x
PubMed ID:
19419389
Additional Links:
DOI: 10.1111/j.1399-5618.2009.00673.x
Abstract:
Neurocognitive dysfunction is likely to represent a trait characteristic of bipolar disorder, but the extent to which it comprises 'core' deficits as opposed to those secondary to longstanding illness or intellectual decline is unclear. We investigated neuropsychological performance in an epidemiologically derived sample of patients with a first affective episode with psychotic symptoms and a positive history of mania, compared to community controls.; Using a nested case-control, population-based study, measures of episodic and working memory, executive function, processing speed, and visual-spatial perception were compared between 35 patients with a first affective episode with psychotic symptoms and a positive history of mania, and 274 community controls, as well as a subgroup of 105 controls matched on current IQ ('good' versus 'poor') and IQ trajectory ('stable', 'declined', or 'improved') with the patients (three controls per case).; Compared to the extended control sample, probands showed a suggestive deficit in short-term verbal recall, and a significant deficit in semantic fluency. Only the latter was detectable in the comparison with the IQ-matched controls. All other neurocognitive domains showed intact performance or nonsignificant deficits of small effect sizes compared to both control groups. Semantic fluency showed no association with symptoms or duration of untreated illness.; Patients with a first affective episode with psychotic symptoms and a positive history of mania show an isolated, selective deficit in semantic verbal fluency, against a background of generally preserved neurocognitive function. This pattern seems to contrast with the more widespread neuropsychological dysfunction seen in schizophrenia.
Language:
en
MeSH:
Adolescent; Adult; Affective Disorders, Psychotic; Bipolar Disorder; Case-Control Studies; Cognition Disorders; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Psychiatric Status Rating Scales; Semantics; Statistics, Nonparametric; Verbal Behavior
ISSN:
1399-5618

Full metadata record

DC FieldValue Language
dc.contributor.authorKravariti, Eugeniaen
dc.contributor.authorReichenberg, Abrahamen
dc.contributor.authorMorgan, Kevinen
dc.contributor.authorDazzan, Paolaen
dc.contributor.authorMorgan, Craigen
dc.contributor.authorZanelli, Jolanta Wen
dc.contributor.authorLappin, Julia Men
dc.contributor.authorDoody, Gillian Aen
dc.contributor.authorHarrison, Glynnen
dc.contributor.authorJones, Peter Ben
dc.contributor.authorMurray, Robin Men
dc.contributor.authorFearon, Paulen
dc.date.accessioned2011-04-27T11:12:55Z-
dc.date.available2011-04-27T11:12:55Z-
dc.date.issued2009-05-
dc.identifier.citationSelective deficits in semantic verbal fluency in patients with a first affective episode with psychotic symptoms and a positive history of mania. 2009, 11 (3):323-9 Bipolar Disorden
dc.identifier.issn1399-5618-
dc.identifier.pmid19419389-
dc.identifier.doi10.1111/j.1399-5618.2009.00673.x-
dc.identifier.urihttp://hdl.handle.net/10147/128758-
dc.description.abstractNeurocognitive dysfunction is likely to represent a trait characteristic of bipolar disorder, but the extent to which it comprises 'core' deficits as opposed to those secondary to longstanding illness or intellectual decline is unclear. We investigated neuropsychological performance in an epidemiologically derived sample of patients with a first affective episode with psychotic symptoms and a positive history of mania, compared to community controls.-
dc.description.abstractUsing a nested case-control, population-based study, measures of episodic and working memory, executive function, processing speed, and visual-spatial perception were compared between 35 patients with a first affective episode with psychotic symptoms and a positive history of mania, and 274 community controls, as well as a subgroup of 105 controls matched on current IQ ('good' versus 'poor') and IQ trajectory ('stable', 'declined', or 'improved') with the patients (three controls per case).-
dc.description.abstractCompared to the extended control sample, probands showed a suggestive deficit in short-term verbal recall, and a significant deficit in semantic fluency. Only the latter was detectable in the comparison with the IQ-matched controls. All other neurocognitive domains showed intact performance or nonsignificant deficits of small effect sizes compared to both control groups. Semantic fluency showed no association with symptoms or duration of untreated illness.-
dc.description.abstractPatients with a first affective episode with psychotic symptoms and a positive history of mania show an isolated, selective deficit in semantic verbal fluency, against a background of generally preserved neurocognitive function. This pattern seems to contrast with the more widespread neuropsychological dysfunction seen in schizophrenia.-
dc.language.isoenen
dc.relation.urlDOI: 10.1111/j.1399-5618.2009.00673.xen
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAffective Disorders, Psychotic-
dc.subject.meshBipolar Disorder-
dc.subject.meshCase-Control Studies-
dc.subject.meshCognition Disorders-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeuropsychological Tests-
dc.subject.meshPsychiatric Status Rating Scales-
dc.subject.meshSemantics-
dc.subject.meshStatistics, Nonparametric-
dc.subject.meshVerbal Behavior-
dc.titleSelective deficits in semantic verbal fluency in patients with a first affective episode with psychotic symptoms and a positive history of mania.en
dc.contributor.departmentDepartment of Psychiatry, NIHR Biomedical Research Centre, Maudsley NHS Foundation Trust/Institute of Psychiatry, King's College London, Box 58, De Crespigny Park, London SE5 8AF, UK. e.kravariti@iop.kcl.ac.uken
dc.identifier.journalBipolar disordersen
dc.description.provinceLeinster-

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