Specific and generalized neuropsychological deficits: a comparison of patients with various first-episode psychosis presentations.

Hdl Handle:
http://hdl.handle.net/10147/128749
Title:
Specific and generalized neuropsychological deficits: a comparison of patients with various first-episode psychosis presentations.
Authors:
Zanelli, Jolanta; Reichenberg, Abraham; Morgan, Kevin; Fearon, Paul; Kravariti, Eugenia; Dazzan, Paola; Morgan, Craig; Zanelli, Caroline; Demjaha, Arsime; Jones, Peter B; Doody, Gillian A; Kapur, Shitij; Murray, Robin M
Affiliation:
Institute of Psychiatry, PO63, Division of Psychological Medicine and Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK. jolanta.zanelli@iop.kcl.ac.uk
Citation:
Specific and generalized neuropsychological deficits: a comparison of patients with various first-episode psychosis presentations. 2010, 167 (1):78-85 Am J Psychiatry
Journal:
The American journal of psychiatry
Issue Date:
Jan-2010
URI:
http://hdl.handle.net/10147/128749
DOI:
10.1176/appi.ajp.2009.09010118
PubMed ID:
19952077
Additional Links:
http://ajp.psychiatryonline.org/cgi/content/full/167/1/78
Abstract:
Overwhelming evidence suggests that compromised neuropsychological function is frequently observed in schizophrenia. Neurocognitive dysfunction has often been reported in other psychotic disorders, although there are inconsistencies in the literature. In the context of four distinct diagnostic groups, the authors compared neuropsychological performance among patients experiencing their first psychotic episode.; Data were derived from a population-based, case-control study of patients with first-episode psychosis. A neuropsychological test battery was administered to patients with a diagnosis of schizophrenia (N=65), bipolar disorder or mania (N=37), depressive psychosis (N=39), or other psychotic disorders (N=46) following index presentation, as well as to healthy comparison subjects (N=177). The presence of specific and generalized cognitive deficits was examined.; The schizophrenia group presented widespread neuropsychological impairments and performed significantly worse than healthy comparison subjects on most neuropsychological measures. Patients with other psychotic disorders and depressive psychosis also demonstrated widespread impairments. Deficits in patients with bipolar disorder or mania were less pervasive but evident in performance scores on verbal memory and fluency tests. Differences between the four patient groups and healthy comparison subjects and among the patient groups were attenuated after controlling for differences in general cognitive ability (IQ).; Early in their course, cognitive deficits are present in all psychotic disorders but are most severe and pervasive in schizophrenia and least pervasive in bipolar disorder and mania.
Item Type:
Article
Language:
en
MeSH:
Adolescent; Adult; Aged; Bipolar Disorder; Case-Control Studies; Cognition Disorders; Depressive Disorder, Major; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Psychiatric Status Rating Scales; Psychometrics; Psychotic Disorders; Risk Factors; Schizophrenia; Schizophrenic Psychology; Severity of Illness Index
ISSN:
1535-7228

Full metadata record

DC FieldValue Language
dc.contributor.authorZanelli, Jolantaen
dc.contributor.authorReichenberg, Abrahamen
dc.contributor.authorMorgan, Kevinen
dc.contributor.authorFearon, Paulen
dc.contributor.authorKravariti, Eugeniaen
dc.contributor.authorDazzan, Paolaen
dc.contributor.authorMorgan, Craigen
dc.contributor.authorZanelli, Carolineen
dc.contributor.authorDemjaha, Arsimeen
dc.contributor.authorJones, Peter Ben
dc.contributor.authorDoody, Gillian Aen
dc.contributor.authorKapur, Shitijen
dc.contributor.authorMurray, Robin Men
dc.date.accessioned2011-04-27T10:44:54Z-
dc.date.available2011-04-27T10:44:54Z-
dc.date.issued2010-01-
dc.identifier.citationSpecific and generalized neuropsychological deficits: a comparison of patients with various first-episode psychosis presentations. 2010, 167 (1):78-85 Am J Psychiatryen
dc.identifier.issn1535-7228-
dc.identifier.pmid19952077-
dc.identifier.doi10.1176/appi.ajp.2009.09010118-
dc.identifier.urihttp://hdl.handle.net/10147/128749-
dc.description.abstractOverwhelming evidence suggests that compromised neuropsychological function is frequently observed in schizophrenia. Neurocognitive dysfunction has often been reported in other psychotic disorders, although there are inconsistencies in the literature. In the context of four distinct diagnostic groups, the authors compared neuropsychological performance among patients experiencing their first psychotic episode.-
dc.description.abstractData were derived from a population-based, case-control study of patients with first-episode psychosis. A neuropsychological test battery was administered to patients with a diagnosis of schizophrenia (N=65), bipolar disorder or mania (N=37), depressive psychosis (N=39), or other psychotic disorders (N=46) following index presentation, as well as to healthy comparison subjects (N=177). The presence of specific and generalized cognitive deficits was examined.-
dc.description.abstractThe schizophrenia group presented widespread neuropsychological impairments and performed significantly worse than healthy comparison subjects on most neuropsychological measures. Patients with other psychotic disorders and depressive psychosis also demonstrated widespread impairments. Deficits in patients with bipolar disorder or mania were less pervasive but evident in performance scores on verbal memory and fluency tests. Differences between the four patient groups and healthy comparison subjects and among the patient groups were attenuated after controlling for differences in general cognitive ability (IQ).-
dc.description.abstractEarly in their course, cognitive deficits are present in all psychotic disorders but are most severe and pervasive in schizophrenia and least pervasive in bipolar disorder and mania.-
dc.language.isoenen
dc.relation.urlhttp://ajp.psychiatryonline.org/cgi/content/full/167/1/78en
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshBipolar Disorder-
dc.subject.meshCase-Control Studies-
dc.subject.meshCognition Disorders-
dc.subject.meshDepressive Disorder, Major-
dc.subject.meshDiagnosis, Differential-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeuropsychological Tests-
dc.subject.meshPsychiatric Status Rating Scales-
dc.subject.meshPsychometrics-
dc.subject.meshPsychotic Disorders-
dc.subject.meshRisk Factors-
dc.subject.meshSchizophrenia-
dc.subject.meshSchizophrenic Psychology-
dc.subject.meshSeverity of Illness Index-
dc.titleSpecific and generalized neuropsychological deficits: a comparison of patients with various first-episode psychosis presentations.en
dc.typeArticleen
dc.contributor.departmentInstitute of Psychiatry, PO63, Division of Psychological Medicine and Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK. jolanta.zanelli@iop.kcl.ac.uken
dc.identifier.journalThe American journal of psychiatryen
dc.description.provinceLeinster-

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