Expression of the neuronal adaptor protein X11alpha protects against memory dysfunction in a transgenic mouse model of Alzheimer's disease.

Hdl Handle:
http://hdl.handle.net/10147/128733
Title:
Expression of the neuronal adaptor protein X11alpha protects against memory dysfunction in a transgenic mouse model of Alzheimer's disease.
Authors:
Mitchell, Jacqueline C; Perkinton, Michael S; Yates, Darran M; Lau, Kwok-Fai; Rogelj, Boris; Miller, Christopher C J; McLoughlin, Declan M
Affiliation:
MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, London, UK.
Citation:
Expression of the neuronal adaptor protein X11alpha protects against memory dysfunction in a transgenic mouse model of Alzheimer's disease. 2010, 20 (1):31-6 J. Alzheimers Dis.
Journal:
Journal of Alzheimer's disease : JAD
Issue Date:
2010
URI:
http://hdl.handle.net/10147/128733
DOI:
10.3233/JAD-2009-1341
PubMed ID:
20378958
Abstract:
X11alpha is a neuronal-specific adaptor protein that binds to the amyloid-beta protein precursor (AbetaPP). Overexpression of X11alpha reduces Abeta production but whether X11alpha also protects against Abeta-related memory dysfunction is not known. To test this possibility, we crossed X11alpha transgenic mice with AbetaPP-Tg2576 mice. AbetaPP-Tg2576 mice produce high levels of brain Abeta and develop age-related defects in memory function that correlate with increasing Abeta load. Overexpression of X11alpha alone had no detectable adverse effect upon behavior. However, X11alpha reduced brain Abeta levels and corrected spatial reference memory defects in aged X11alpha/AbetaPP double transgenics. Thus, X11alpha may be a therapeutic target for Alzheimer's disease.
Item Type:
Article
Language:
en
MeSH:
Adaptor Proteins, Signal Transducing; Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Disease Models, Animal; Humans; Maze Learning; Memory Disorders; Mice; Mice, Transgenic; Nerve Tissue Proteins
ISSN:
1875-8908

Full metadata record

DC FieldValue Language
dc.contributor.authorMitchell, Jacqueline Cen
dc.contributor.authorPerkinton, Michael Sen
dc.contributor.authorYates, Darran Men
dc.contributor.authorLau, Kwok-Faien
dc.contributor.authorRogelj, Borisen
dc.contributor.authorMiller, Christopher C Jen
dc.contributor.authorMcLoughlin, Declan Men
dc.date.accessioned2011-04-27T09:15:40Z-
dc.date.available2011-04-27T09:15:40Z-
dc.date.issued2010-
dc.identifier.citationExpression of the neuronal adaptor protein X11alpha protects against memory dysfunction in a transgenic mouse model of Alzheimer's disease. 2010, 20 (1):31-6 J. Alzheimers Dis.en
dc.identifier.issn1875-8908-
dc.identifier.pmid20378958-
dc.identifier.doi10.3233/JAD-2009-1341-
dc.identifier.urihttp://hdl.handle.net/10147/128733-
dc.description.abstractX11alpha is a neuronal-specific adaptor protein that binds to the amyloid-beta protein precursor (AbetaPP). Overexpression of X11alpha reduces Abeta production but whether X11alpha also protects against Abeta-related memory dysfunction is not known. To test this possibility, we crossed X11alpha transgenic mice with AbetaPP-Tg2576 mice. AbetaPP-Tg2576 mice produce high levels of brain Abeta and develop age-related defects in memory function that correlate with increasing Abeta load. Overexpression of X11alpha alone had no detectable adverse effect upon behavior. However, X11alpha reduced brain Abeta levels and corrected spatial reference memory defects in aged X11alpha/AbetaPP double transgenics. Thus, X11alpha may be a therapeutic target for Alzheimer's disease.-
dc.language.isoenen
dc.subject.meshAdaptor Proteins, Signal Transducing-
dc.subject.meshAge Factors-
dc.subject.meshAlzheimer Disease-
dc.subject.meshAmyloid beta-Peptides-
dc.subject.meshAmyloid beta-Protein Precursor-
dc.subject.meshAnalysis of Variance-
dc.subject.meshAnimals-
dc.subject.meshDisease Models, Animal-
dc.subject.meshHumans-
dc.subject.meshMaze Learning-
dc.subject.meshMemory Disorders-
dc.subject.meshMice-
dc.subject.meshMice, Transgenic-
dc.subject.meshNerve Tissue Proteins-
dc.titleExpression of the neuronal adaptor protein X11alpha protects against memory dysfunction in a transgenic mouse model of Alzheimer's disease.en
dc.typeArticleen
dc.contributor.departmentMRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, London, UK.en
dc.identifier.journalJournal of Alzheimer's disease : JADen
dc.description.provinceLeinster-

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