Riluzole protects against glutamate-induced slowing of neurofilament axonal transport.

Hdl Handle:
http://hdl.handle.net/10147/128718
Title:
Riluzole protects against glutamate-induced slowing of neurofilament axonal transport.
Authors:
Stevenson, Alison; Yates, Darran M; Manser, Catherine; De Vos, Kurt J; Vagnoni, Alessio; Leigh, P Nigel; McLoughlin, Declan M; Miller, Christopher C J
Affiliation:
MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King's College, London, UK.
Citation:
Riluzole protects against glutamate-induced slowing of neurofilament axonal transport. 2009, 454 (2):161-4 Neurosci. Lett.
Journal:
Neuroscience letters
Issue Date:
24-Apr-2009
URI:
http://hdl.handle.net/10147/128718
DOI:
10.1016/j.neulet.2009.02.061
PubMed ID:
19429076
Additional Links:
doi:10.1016/j.neulet.2009.02.061
Abstract:
Riluzole is the only drug approved for the treatment of amyotrophic lateral sclerosis (ALS) but its precise mode of action is not properly understood. Damage to axonal transport of neurofilaments is believed to be part of the pathogenic mechanism in ALS and this has been linked to defective glutamate handling and increased phosphorylation of neurofilament side-arm domains. Here, we show that riluzole protects against glutamate-induced slowing of neurofilament transport. Protection is associated with decreased neurofilament side-arm phosphorylation and inhibition of the activities of two neurofilament kinases, ERK and p38 that are activated in ALS. Thus, the anti-glutamatergic properties of riluzole include protection against glutamate-induced changes to neurofilament phosphorylation and transport.
Item Type:
Article
Language:
en
MeSH:
Analysis of Variance; Animals; Axonal Transport; Axons; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; Immunohistochemistry; Neurofilament Proteins; Neurons; Neuroprotective Agents; Phosphorylation; Rats; Riluzole; p38 Mitogen-Activated Protein Kinases
ISSN:
0304-3940

Full metadata record

DC FieldValue Language
dc.contributor.authorStevenson, Alisonen
dc.contributor.authorYates, Darran Men
dc.contributor.authorManser, Catherineen
dc.contributor.authorDe Vos, Kurt Jen
dc.contributor.authorVagnoni, Alessioen
dc.contributor.authorLeigh, P Nigelen
dc.contributor.authorMcLoughlin, Declan Men
dc.contributor.authorMiller, Christopher C Jen
dc.date.accessioned2011-04-27T09:27:26Z-
dc.date.available2011-04-27T09:27:26Z-
dc.date.issued2009-04-24-
dc.identifier.citationRiluzole protects against glutamate-induced slowing of neurofilament axonal transport. 2009, 454 (2):161-4 Neurosci. Lett.en
dc.identifier.issn0304-3940-
dc.identifier.pmid19429076-
dc.identifier.doi10.1016/j.neulet.2009.02.061-
dc.identifier.urihttp://hdl.handle.net/10147/128718-
dc.description.abstractRiluzole is the only drug approved for the treatment of amyotrophic lateral sclerosis (ALS) but its precise mode of action is not properly understood. Damage to axonal transport of neurofilaments is believed to be part of the pathogenic mechanism in ALS and this has been linked to defective glutamate handling and increased phosphorylation of neurofilament side-arm domains. Here, we show that riluzole protects against glutamate-induced slowing of neurofilament transport. Protection is associated with decreased neurofilament side-arm phosphorylation and inhibition of the activities of two neurofilament kinases, ERK and p38 that are activated in ALS. Thus, the anti-glutamatergic properties of riluzole include protection against glutamate-induced changes to neurofilament phosphorylation and transport.-
dc.language.isoenen
dc.relation.urldoi:10.1016/j.neulet.2009.02.061en
dc.subject.meshAnalysis of Variance-
dc.subject.meshAnimals-
dc.subject.meshAxonal Transport-
dc.subject.meshAxons-
dc.subject.meshBrain-
dc.subject.meshCells, Cultured-
dc.subject.meshDose-Response Relationship, Drug-
dc.subject.meshExcitatory Amino Acid Antagonists-
dc.subject.meshExtracellular Signal-Regulated MAP Kinases-
dc.subject.meshGlutamic Acid-
dc.subject.meshImmunohistochemistry-
dc.subject.meshNeurofilament Proteins-
dc.subject.meshNeurons-
dc.subject.meshNeuroprotective Agents-
dc.subject.meshPhosphorylation-
dc.subject.meshRats-
dc.subject.meshRiluzole-
dc.subject.meshp38 Mitogen-Activated Protein Kinases-
dc.titleRiluzole protects against glutamate-induced slowing of neurofilament axonal transport.en
dc.typeArticleen
dc.contributor.departmentMRC Centre for Neurodegeneration Research, Institute of Psychiatry, King's College, London, UK.en
dc.identifier.journalNeuroscience lettersen
dc.description.provinceLeinster-

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