An evoked auditory response fMRI study of the effects of rTMS on putative AVH pathways in healthy volunteers.

Hdl Handle:
http://hdl.handle.net/10147/128716
Title:
An evoked auditory response fMRI study of the effects of rTMS on putative AVH pathways in healthy volunteers.
Authors:
Tracy, D K; O'Daly, O; Joyce, D W; Michalopoulou, P G; Basit, B B; Dhillon, G; McLoughlin, D M; Shergill, S S
Affiliation:
CSI Lab, Department of Psychological Medicine, The Institute of Psychiatry, King's College London, UK. d.tracy@iop.kcl.ac.uk
Citation:
An evoked auditory response fMRI study of the effects of rTMS on putative AVH pathways in healthy volunteers. 2010, 48 (1):270-7 Neuropsychologia
Journal:
Neuropsychologia
Issue Date:
Jan-2010
URI:
http://hdl.handle.net/10147/128716
DOI:
10.1016/j.neuropsychologia.2009.09.013
PubMed ID:
19769994
Additional Links:
doi:10.1016/j.neuropsychologia.2009.09.013
Abstract:
Auditory verbal hallucinations (AVH) are the most prevalent symptom in schizophrenia. They are associated with increased activation within the temporoparietal cortices and are refractory to pharmacological and psychological treatment in approximately 25% of patients. Low frequency repetitive transcranial magnetic stimulation (rTMS) over the temporoparietal cortex has been demonstrated to be effective in reducing AVH in some patients, although results have varied. The cortical mechanism by which rTMS exerts its effects remain unknown, although data from the motor system is suggestive of a local cortical inhibitory effect. We explored neuroimaging differences in healthy volunteers between application of a clinically utilized rTMS protocol and a sham rTMS equivalent when undertaking a prosodic auditory task.; Single-blind placebo controlled fMRI study of 24 healthy volunteers undertaking an auditory temporoparietal activation task, who received either right temporoparietal rTMS or sham RTMS.; The main effect of group was bilateral inferior parietal deactivation following real rTMS. An interaction of group and task type showed deactivation during real rTMS in the right superior temporal gyrus (STG), left thalamus, left postcentral gyrus and cerebellum. However, the left parietal lobe showed an increase in activation following right sided real rTMS, but this increase was specific to a non-linguistic, tone-sequence task.; rTMS does cause local inhibitory effects, not only in the underlying region of application, but also in functionally connected cortical regions. However, there is also a related, task dependent, increase in activation within selected cortical areas in the contralateral hemisphere; these are likely to reflect compensatory mechanisms, and such cortical activation may in some cases contribute to, or retard, some of the therapeutic effects seen with rTMS.
Item Type:
Article
Language:
en
MeSH:
Acoustic Stimulation; Adolescent; Adult; Analysis of Variance; Brain; Brain Mapping; Evoked Potentials, Auditory; Female; Hallucinations; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Oxygen; Single-Blind Method; Transcranial Magnetic Stimulation; Young Adult
ISSN:
1873-3514

Full metadata record

DC FieldValue Language
dc.contributor.authorTracy, D Ken
dc.contributor.authorO'Daly, Oen
dc.contributor.authorJoyce, D Wen
dc.contributor.authorMichalopoulou, P Gen
dc.contributor.authorBasit, B Ben
dc.contributor.authorDhillon, Gen
dc.contributor.authorMcLoughlin, D Men
dc.contributor.authorShergill, S Sen
dc.date.accessioned2011-04-27T09:17:28Z-
dc.date.available2011-04-27T09:17:28Z-
dc.date.issued2010-01-
dc.identifier.citationAn evoked auditory response fMRI study of the effects of rTMS on putative AVH pathways in healthy volunteers. 2010, 48 (1):270-7 Neuropsychologiaen
dc.identifier.issn1873-3514-
dc.identifier.pmid19769994-
dc.identifier.doi10.1016/j.neuropsychologia.2009.09.013-
dc.identifier.urihttp://hdl.handle.net/10147/128716-
dc.description.abstractAuditory verbal hallucinations (AVH) are the most prevalent symptom in schizophrenia. They are associated with increased activation within the temporoparietal cortices and are refractory to pharmacological and psychological treatment in approximately 25% of patients. Low frequency repetitive transcranial magnetic stimulation (rTMS) over the temporoparietal cortex has been demonstrated to be effective in reducing AVH in some patients, although results have varied. The cortical mechanism by which rTMS exerts its effects remain unknown, although data from the motor system is suggestive of a local cortical inhibitory effect. We explored neuroimaging differences in healthy volunteers between application of a clinically utilized rTMS protocol and a sham rTMS equivalent when undertaking a prosodic auditory task.-
dc.description.abstractSingle-blind placebo controlled fMRI study of 24 healthy volunteers undertaking an auditory temporoparietal activation task, who received either right temporoparietal rTMS or sham RTMS.-
dc.description.abstractThe main effect of group was bilateral inferior parietal deactivation following real rTMS. An interaction of group and task type showed deactivation during real rTMS in the right superior temporal gyrus (STG), left thalamus, left postcentral gyrus and cerebellum. However, the left parietal lobe showed an increase in activation following right sided real rTMS, but this increase was specific to a non-linguistic, tone-sequence task.-
dc.description.abstractrTMS does cause local inhibitory effects, not only in the underlying region of application, but also in functionally connected cortical regions. However, there is also a related, task dependent, increase in activation within selected cortical areas in the contralateral hemisphere; these are likely to reflect compensatory mechanisms, and such cortical activation may in some cases contribute to, or retard, some of the therapeutic effects seen with rTMS.-
dc.language.isoenen
dc.relation.urldoi:10.1016/j.neuropsychologia.2009.09.013en
dc.subject.meshAcoustic Stimulation-
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAnalysis of Variance-
dc.subject.meshBrain-
dc.subject.meshBrain Mapping-
dc.subject.meshEvoked Potentials, Auditory-
dc.subject.meshFemale-
dc.subject.meshHallucinations-
dc.subject.meshHumans-
dc.subject.meshImage Processing, Computer-Assisted-
dc.subject.meshMagnetic Resonance Imaging-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshOxygen-
dc.subject.meshSingle-Blind Method-
dc.subject.meshTranscranial Magnetic Stimulation-
dc.subject.meshYoung Adult-
dc.titleAn evoked auditory response fMRI study of the effects of rTMS on putative AVH pathways in healthy volunteers.en
dc.typeArticleen
dc.contributor.departmentCSI Lab, Department of Psychological Medicine, The Institute of Psychiatry, King's College London, UK. d.tracy@iop.kcl.ac.uken
dc.identifier.journalNeuropsychologiaen
dc.description.provinceLeinster-

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.