An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter.

Hdl Handle:
http://hdl.handle.net/10147/128714
Title:
An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter.
Authors:
Lau, Kwok-Fai; Perkinton, Michael S; Rodriguez, Lilia; McLoughlin, Declan M; Miller, Christopher C J
Affiliation:
Department of Biochemistry Science, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR. kflau@cuhk.edu.hk
Citation:
An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter. 2010, 21 (11):761-6 Neuroreport
Journal:
Neuroreport
Issue Date:
4-Aug-2010
URI:
http://hdl.handle.net/10147/128714
DOI:
10.1097/WNR.0b013e32833bfca0
PubMed ID:
20531236
Additional Links:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896363/?tool=pubmed
Abstract:
X11alpha is a neuronal adaptor protein that interacts with the amyloid precursor protein (APP) through a centrally located phosphotyrosine binding domain to inhibit the production of Abeta peptide that is deposited in Alzheimer's disease brains. X11alpha also contains two C-terminal postsynaptic density-95, large discs, zona occludens 1 (PDZ) domains, and we show here that through its PDZ domains, X11alpha interacts with a novel transcription factor, fibrinogen silencer binding protein. Moreover, we show that an X11alpha/fibrinogen silencer binding protein complex signals to the nucleus to repress glycogen synthase kinase-3beta promoter activity. Glycogen synthase kinase-3beta is a favoured candidate kinase for phosphorylating tau in Alzheimer's disease. Our findings show a new function for X11alpha that may impact on Alzheimer's disease pathogenesis.
Item Type:
Article
Language:
en
MeSH:
Adaptor Proteins, Signal Transducing; Alzheimer Disease; Animals; Blotting, Northern; Brain; CHO Cells; Cricetinae; Cricetulus; Gene Expression Regulation; Glycogen Synthase Kinase 3; Humans; Multiprotein Complexes; Nerve Tissue Proteins; Promoter Regions, Genetic; Rats; Transcription Factors; Transcription, Genetic; Transfection; Two-Hybrid System Techniques
ISSN:
1473-558X

Full metadata record

DC FieldValue Language
dc.contributor.authorLau, Kwok-Faien
dc.contributor.authorPerkinton, Michael Sen
dc.contributor.authorRodriguez, Liliaen
dc.contributor.authorMcLoughlin, Declan Men
dc.contributor.authorMiller, Christopher C Jen
dc.date.accessioned2011-04-27T09:06:48Z-
dc.date.available2011-04-27T09:06:48Z-
dc.date.issued2010-08-04-
dc.identifier.citationAn X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter. 2010, 21 (11):761-6 Neuroreporten
dc.identifier.issn1473-558X-
dc.identifier.pmid20531236-
dc.identifier.doi10.1097/WNR.0b013e32833bfca0-
dc.identifier.urihttp://hdl.handle.net/10147/128714-
dc.description.abstractX11alpha is a neuronal adaptor protein that interacts with the amyloid precursor protein (APP) through a centrally located phosphotyrosine binding domain to inhibit the production of Abeta peptide that is deposited in Alzheimer's disease brains. X11alpha also contains two C-terminal postsynaptic density-95, large discs, zona occludens 1 (PDZ) domains, and we show here that through its PDZ domains, X11alpha interacts with a novel transcription factor, fibrinogen silencer binding protein. Moreover, we show that an X11alpha/fibrinogen silencer binding protein complex signals to the nucleus to repress glycogen synthase kinase-3beta promoter activity. Glycogen synthase kinase-3beta is a favoured candidate kinase for phosphorylating tau in Alzheimer's disease. Our findings show a new function for X11alpha that may impact on Alzheimer's disease pathogenesis.-
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896363/?tool=pubmeden
dc.subject.meshAdaptor Proteins, Signal Transducing-
dc.subject.meshAlzheimer Disease-
dc.subject.meshAnimals-
dc.subject.meshBlotting, Northern-
dc.subject.meshBrain-
dc.subject.meshCHO Cells-
dc.subject.meshCricetinae-
dc.subject.meshCricetulus-
dc.subject.meshGene Expression Regulation-
dc.subject.meshGlycogen Synthase Kinase 3-
dc.subject.meshHumans-
dc.subject.meshMultiprotein Complexes-
dc.subject.meshNerve Tissue Proteins-
dc.subject.meshPromoter Regions, Genetic-
dc.subject.meshRats-
dc.subject.meshTranscription Factors-
dc.subject.meshTranscription, Genetic-
dc.subject.meshTransfection-
dc.subject.meshTwo-Hybrid System Techniques-
dc.titleAn X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter.en
dc.typeArticleen
dc.contributor.departmentDepartment of Biochemistry Science, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR. kflau@cuhk.edu.hken
dc.identifier.journalNeuroreporten
dc.description.provinceLeinster-

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