Recovery of older patients undergoing ambulatory anaesthesia with isoflurane or sevoflurane.

Hdl Handle:
http://hdl.handle.net/10147/127917
Title:
Recovery of older patients undergoing ambulatory anaesthesia with isoflurane or sevoflurane.
Authors:
Mahajan, V A; Ni Chonghaile, M; Bokhari, S A; Harte, B H; Flynn, N M; Laffey, J G
Affiliation:
National University of Ireland, Clinical Sciences Institute, and National Centre for Biomedical Engineering Sciences (NCBES), Department of Anaesthesia, Galway, Ireland.
Citation:
Recovery of older patients undergoing ambulatory anaesthesia with isoflurane or sevoflurane. 2007, 24 (6):505-10 Eur J Anaesthesiol
Journal:
European journal of anaesthesiology
Issue Date:
Jun-2007
URI:
http://hdl.handle.net/10147/127917
DOI:
10.1017/S0265021506001980
PubMed ID:
17202009
Abstract:
Delayed recovery of cognitive function is a well-recognized phenomenon in older patients. The potential for the volatile anaesthetic used to contribute to alterations in postoperative cognitive function in older patients following minor surgical procedures has not been determined. We compared emergence from isoflurane and sevoflurane anaesthesia in older surgical patients undergoing urological procedures of short duration.; Seventy-one patients, 60 yr of age or older, undergoing anaesthesia expected to last less than 60 min for ambulatory surgery, were randomly assigned to receive isoflurane or sevoflurane. A standardized anaesthetic protocol was used, with intravenous fentanyl 1 microg kg(-1) and propofol 1.5-2.0 mg kg(-1) administered to induce anaesthesia. Anaesthesia was maintained with either sevoflurane or isoflurane in 65% nitrous oxide and oxygen. Early and intermediate recovery times were recorded. The Mini Mental State Examination and digit repetition forwards and backwards were administered at baseline, and at 1, 3 and 6 h postoperatively, to assess cognitive function.; There were no between-group differences in (sevoflurane vs. isoflurane, mean +/- standard error of the mean) times to removal of the laryngeal mask airway (7.7 +/- 0.6 vs. 7.1 +/- 0.4 min), verbal response time (10.1 +/- 0.7 vs. 9.9 +/- 0.7 min) and orientation (12.1 +/- 0.7 vs. 12.1 +/- 0.7 min). Intermediate recovery, as measured by time to readiness for discharge from the post anaesthesia care unit (44.9 +/- 1.5 vs. 44.3 +/- 1.5 min), was similar in the two groups. Postoperative indices of cognitive function and attention were comparably reduced at 1 h, but returned to baseline in both groups at 6 h.; Isoflurane and sevoflurane anaesthesia resulted in similar clinical and neurocognitive recovery profiles in older patients undergoing ambulatory surgical procedures of short duration.
Item Type:
Article
Language:
en
MeSH:
Aged; Ambulatory Surgical Procedures; Analysis of Variance; Anesthesia, Inhalation; Anesthetics, Inhalation; Cognition Disorders; Double-Blind Method; Female; Humans; Isoflurane; Male; Methyl Ethers; Neuropsychological Tests; Orientation; Prospective Studies; Time Factors; Urologic Surgical Procedures
ISSN:
0265-0215

Full metadata record

DC FieldValue Language
dc.contributor.authorMahajan, V Aen
dc.contributor.authorNi Chonghaile, Men
dc.contributor.authorBokhari, S Aen
dc.contributor.authorHarte, B Hen
dc.contributor.authorFlynn, N Men
dc.contributor.authorLaffey, J Gen
dc.date.accessioned2011-04-11T10:23:32Z-
dc.date.available2011-04-11T10:23:32Z-
dc.date.issued2007-06-
dc.identifier.citationRecovery of older patients undergoing ambulatory anaesthesia with isoflurane or sevoflurane. 2007, 24 (6):505-10 Eur J Anaesthesiolen
dc.identifier.issn0265-0215-
dc.identifier.pmid17202009-
dc.identifier.doi10.1017/S0265021506001980-
dc.identifier.urihttp://hdl.handle.net/10147/127917-
dc.description.abstractDelayed recovery of cognitive function is a well-recognized phenomenon in older patients. The potential for the volatile anaesthetic used to contribute to alterations in postoperative cognitive function in older patients following minor surgical procedures has not been determined. We compared emergence from isoflurane and sevoflurane anaesthesia in older surgical patients undergoing urological procedures of short duration.-
dc.description.abstractSeventy-one patients, 60 yr of age or older, undergoing anaesthesia expected to last less than 60 min for ambulatory surgery, were randomly assigned to receive isoflurane or sevoflurane. A standardized anaesthetic protocol was used, with intravenous fentanyl 1 microg kg(-1) and propofol 1.5-2.0 mg kg(-1) administered to induce anaesthesia. Anaesthesia was maintained with either sevoflurane or isoflurane in 65% nitrous oxide and oxygen. Early and intermediate recovery times were recorded. The Mini Mental State Examination and digit repetition forwards and backwards were administered at baseline, and at 1, 3 and 6 h postoperatively, to assess cognitive function.-
dc.description.abstractThere were no between-group differences in (sevoflurane vs. isoflurane, mean +/- standard error of the mean) times to removal of the laryngeal mask airway (7.7 +/- 0.6 vs. 7.1 +/- 0.4 min), verbal response time (10.1 +/- 0.7 vs. 9.9 +/- 0.7 min) and orientation (12.1 +/- 0.7 vs. 12.1 +/- 0.7 min). Intermediate recovery, as measured by time to readiness for discharge from the post anaesthesia care unit (44.9 +/- 1.5 vs. 44.3 +/- 1.5 min), was similar in the two groups. Postoperative indices of cognitive function and attention were comparably reduced at 1 h, but returned to baseline in both groups at 6 h.-
dc.description.abstractIsoflurane and sevoflurane anaesthesia resulted in similar clinical and neurocognitive recovery profiles in older patients undergoing ambulatory surgical procedures of short duration.-
dc.language.isoenen
dc.subject.meshAged-
dc.subject.meshAmbulatory Surgical Procedures-
dc.subject.meshAnalysis of Variance-
dc.subject.meshAnesthesia, Inhalation-
dc.subject.meshAnesthetics, Inhalation-
dc.subject.meshCognition Disorders-
dc.subject.meshDouble-Blind Method-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshIsoflurane-
dc.subject.meshMale-
dc.subject.meshMethyl Ethers-
dc.subject.meshNeuropsychological Tests-
dc.subject.meshOrientation-
dc.subject.meshProspective Studies-
dc.subject.meshTime Factors-
dc.subject.meshUrologic Surgical Procedures-
dc.titleRecovery of older patients undergoing ambulatory anaesthesia with isoflurane or sevoflurane.en
dc.typeArticleen
dc.contributor.departmentNational University of Ireland, Clinical Sciences Institute, and National Centre for Biomedical Engineering Sciences (NCBES), Department of Anaesthesia, Galway, Ireland.en
dc.identifier.journalEuropean journal of anaesthesiologyen
dc.description.provinceConnacht-

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