A case of stiff-person syndrome, type 1 diabetes, celiac disease and dermatitis herpetiformis.

Hdl Handle:
http://hdl.handle.net/10147/127667
Title:
A case of stiff-person syndrome, type 1 diabetes, celiac disease and dermatitis herpetiformis.
Authors:
O'Sullivan, Eoin P; Behan, Lucy-Ann; King, Tom F J; Hardiman, Orla; Smith, Diarmuid
Affiliation:
Department of Diabetes and Endocrinology, Beaumont Hospital, Dublin 9, Ireland. eoinosullivan@beaumont.ie
Citation:
A case of stiff-person syndrome, type 1 diabetes, celiac disease and dermatitis herpetiformis. 2009, 111 (4):384-6 Clin Neurol Neurosurg
Journal:
Clinical neurology and neurosurgery
Issue Date:
May-2009
URI:
http://hdl.handle.net/10147/127667
DOI:
10.1016/j.clineuro.2008.11.006
PubMed ID:
19150172
Abstract:
Antibodies against glutamic acid decarboxylase (GAD) are involved in the pathophysiology of stiff-person syndrome (SPS) and type 1 diabetes. GAD catalyses the conversion of glutamate to gamma-aminobutyric acid (GABA). GABA acts as a neurotransmitter between neurones, while in pancreatic beta cells it plays an integral role in normal insulin secretion, hence the clinical presentation of muscular spasms in SPS and insulin deficiency in diabetes. Despite this apparent major overlap in pathophysiology, SPS only rarely occurs in individuals with type 1 diabetes. We report the case of a 41-year-old man presenting with a simultaneous diagnosis of both these conditions. His case is unusual in that it is the first reported case in the literature of these conditions occurring in someone with celiac disease (CD) and dermatitis herpetiformis. We discuss why SPS and type 1 diabetes co-exist in only a minority of cases and speculate on the underlying mechanism of the association with CD and dermatitis herpetiformis in our patient.
Item Type:
Article
Language:
en
MeSH:
Adult; Celiac Disease; Comorbidity; Dermatitis Herpetiformis; Diabetes Mellitus, Type 1; Humans; Male; Stiff-Person Syndrome
ISSN:
1872-6968

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Sullivan, Eoin Pen
dc.contributor.authorBehan, Lucy-Annen
dc.contributor.authorKing, Tom F Jen
dc.contributor.authorHardiman, Orlaen
dc.contributor.authorSmith, Diarmuiden
dc.date.accessioned2011-04-07T10:10:22Z-
dc.date.available2011-04-07T10:10:22Z-
dc.date.issued2009-05-
dc.identifier.citationA case of stiff-person syndrome, type 1 diabetes, celiac disease and dermatitis herpetiformis. 2009, 111 (4):384-6 Clin Neurol Neurosurgen
dc.identifier.issn1872-6968-
dc.identifier.pmid19150172-
dc.identifier.doi10.1016/j.clineuro.2008.11.006-
dc.identifier.urihttp://hdl.handle.net/10147/127667-
dc.description.abstractAntibodies against glutamic acid decarboxylase (GAD) are involved in the pathophysiology of stiff-person syndrome (SPS) and type 1 diabetes. GAD catalyses the conversion of glutamate to gamma-aminobutyric acid (GABA). GABA acts as a neurotransmitter between neurones, while in pancreatic beta cells it plays an integral role in normal insulin secretion, hence the clinical presentation of muscular spasms in SPS and insulin deficiency in diabetes. Despite this apparent major overlap in pathophysiology, SPS only rarely occurs in individuals with type 1 diabetes. We report the case of a 41-year-old man presenting with a simultaneous diagnosis of both these conditions. His case is unusual in that it is the first reported case in the literature of these conditions occurring in someone with celiac disease (CD) and dermatitis herpetiformis. We discuss why SPS and type 1 diabetes co-exist in only a minority of cases and speculate on the underlying mechanism of the association with CD and dermatitis herpetiformis in our patient.-
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshCeliac Disease-
dc.subject.meshComorbidity-
dc.subject.meshDermatitis Herpetiformis-
dc.subject.meshDiabetes Mellitus, Type 1-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshStiff-Person Syndrome-
dc.titleA case of stiff-person syndrome, type 1 diabetes, celiac disease and dermatitis herpetiformis.en
dc.typeArticleen
dc.contributor.departmentDepartment of Diabetes and Endocrinology, Beaumont Hospital, Dublin 9, Ireland. eoinosullivan@beaumont.ieen
dc.identifier.journalClinical neurology and neurosurgeryen
dc.description.provinceLeinster-

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