Clinical Immunology Review Series: an approach to the patient with recurrent orogenital ulceration, including Behçet's syndrome.

Hdl Handle:
http://hdl.handle.net/10147/127650
Title:
Clinical Immunology Review Series: an approach to the patient with recurrent orogenital ulceration, including Behçet's syndrome.
Authors:
Keogan, M T
Affiliation:
Department of Immunology, Beaumont Hospital, Dublin, Ireland. marykeogan@beaumont.ie
Citation:
Clinical Immunology Review Series: an approach to the patient with recurrent orogenital ulceration, including Behçet's syndrome. 2009, 156 (1):1-11 Clin. Exp. Immunol.
Journal:
Clinical and experimental immunology
Issue Date:
Apr-2009
URI:
http://hdl.handle.net/10147/127650
DOI:
10.1111/j.1365-2249.2008.03857.x
PubMed ID:
19210521
Additional Links:
http://www.jbc.org/content/284/25/16891.full.pdf+html
Abstract:
Patients presenting with recurrent orogenital ulcers may have complex aphthosis, Behçet's disease, secondary complex aphthosis (e.g. Reiter's syndrome, Crohn's disease, cyclical neutropenia) or non-aphthous disease (including bullous disorders, erythema multiforme, erosive lichen planus). Behçet's syndrome is a multi-system vasculitis of unknown aetiology for which there is no diagnostic test. Diagnosis is based on agreed clinical criteria that require recurrent oral ulcers and two of the following: recurrent genital ulcers, ocular inflammation, defined skin lesions and pathergy. The condition can present with a variety of symptoms, hence a high index of suspicion is necessary. The most common presentation is with recurrent mouth ulcers, often with genital ulcers; however, it may take some years before diagnostic criteria are met. All patients with idiopathic orogenital ulcers should be kept under review, with periodic focused assessment to detect evolution into Behçet's disease. There is often a delay of several years between patients fulfilling diagnostic criteria and a diagnosis being made, which may contribute to the morbidity of this condition. Despite considerable research effort, the aetiology and pathogenesis of this condition remains enigmatic.
Item Type:
Article
Language:
en
MeSH:
Behcet Syndrome; Diagnosis, Differential; Female; Genital Diseases, Female; Genital Diseases, Male; Humans; Male; Recurrence; Stomatitis, Aphthous; Ulcer
ISSN:
1365-2249

Full metadata record

DC FieldValue Language
dc.contributor.authorKeogan, M Ten
dc.date.accessioned2011-04-07T09:09:08Z-
dc.date.available2011-04-07T09:09:08Z-
dc.date.issued2009-04-
dc.identifier.citationClinical Immunology Review Series: an approach to the patient with recurrent orogenital ulceration, including Behçet's syndrome. 2009, 156 (1):1-11 Clin. Exp. Immunol.en
dc.identifier.issn1365-2249-
dc.identifier.pmid19210521-
dc.identifier.doi10.1111/j.1365-2249.2008.03857.x-
dc.identifier.urihttp://hdl.handle.net/10147/127650-
dc.description.abstractPatients presenting with recurrent orogenital ulcers may have complex aphthosis, Behçet's disease, secondary complex aphthosis (e.g. Reiter's syndrome, Crohn's disease, cyclical neutropenia) or non-aphthous disease (including bullous disorders, erythema multiforme, erosive lichen planus). Behçet's syndrome is a multi-system vasculitis of unknown aetiology for which there is no diagnostic test. Diagnosis is based on agreed clinical criteria that require recurrent oral ulcers and two of the following: recurrent genital ulcers, ocular inflammation, defined skin lesions and pathergy. The condition can present with a variety of symptoms, hence a high index of suspicion is necessary. The most common presentation is with recurrent mouth ulcers, often with genital ulcers; however, it may take some years before diagnostic criteria are met. All patients with idiopathic orogenital ulcers should be kept under review, with periodic focused assessment to detect evolution into Behçet's disease. There is often a delay of several years between patients fulfilling diagnostic criteria and a diagnosis being made, which may contribute to the morbidity of this condition. Despite considerable research effort, the aetiology and pathogenesis of this condition remains enigmatic.-
dc.language.isoenen
dc.relation.urlhttp://www.jbc.org/content/284/25/16891.full.pdf+htmlen
dc.subject.meshBehcet Syndrome-
dc.subject.meshDiagnosis, Differential-
dc.subject.meshFemale-
dc.subject.meshGenital Diseases, Female-
dc.subject.meshGenital Diseases, Male-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshRecurrence-
dc.subject.meshStomatitis, Aphthous-
dc.subject.meshUlcer-
dc.titleClinical Immunology Review Series: an approach to the patient with recurrent orogenital ulceration, including Behçet's syndrome.en
dc.typeArticleen
dc.contributor.departmentDepartment of Immunology, Beaumont Hospital, Dublin, Ireland. marykeogan@beaumont.ieen
dc.identifier.journalClinical and experimental immunologyen
dc.description.provinceLeinster-

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