Long-term outcome of intensive initial immunosuppression protocol in pediatric deceased donor renal transplantation.

Hdl Handle:
http://hdl.handle.net/10147/127618
Title:
Long-term outcome of intensive initial immunosuppression protocol in pediatric deceased donor renal transplantation.
Authors:
Olaitan, Oyedolamu K; Zimmermann, Jose A; Shields, William P; Rodriguez-Navas, Guillermo; Awan, Atif; Mohan, Ponnusamy; Little, Dilly M; Hickey, David P
Affiliation:
National Kidney and Pancreas Transplantation Centre, Beaumont Hospital, Dublin, Ireland. oyedolamu@yahoo.com
Citation:
Long-term outcome of intensive initial immunosuppression protocol in pediatric deceased donor renal transplantation. 2010, 14 (1):87-92 Pediatr Transplant
Journal:
Pediatric transplantation
Issue Date:
Feb-2010
URI:
http://hdl.handle.net/10147/127618
DOI:
10.1111/j.1399-3046.2009.01138.x
PubMed ID:
19309452
Abstract:
To report the long-term outcome of deceased donor kidney transplantation in children with emphasis on the use of an intensive initial immunosuppression protocol using R-ATG as antibody induction. Between January 1991 and December 1997, 82 deceased donor kidney transplantations were performed in 75 pediatric recipients. Mean recipient age at transplantation was 12.9 yr and the mean follow-up period was 12.6 yr. All patients received quadruple immunosuppression with steroid, cyclosporine, azathioprine, and antibody induction using R-ATG-Fresenius. Actual one, five, and 10 yr patient survival rates were 99%, 97%, and 94%, respectively; only one patient (1.2%) developed PTLD. Actual one, five, and 10 yr overall graft survival rates were 84%, 71%, and 50%, respectively; there were five cases (6%) of graft thrombosis and the actual immunological graft survival rates were 91%, 78%, and 63% at one, five, and 10 yr, respectively. The use of an intensive initial immunosuppression protocol with R-ATG as antibody induction is safe and effective in pediatric recipients of deceased donor kidneys with excellent immunological graft survival without an increase in PTLD or other neoplasms over a minimum 10-yr follow up.
Item Type:
Article
Language:
en
MeSH:
Adolescent; Adult; Aged; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Graft Rejection; Graft Survival; Humans; Immunosuppression; Immunosuppressive Agents; Ireland; Kidney Transplantation; Male; Middle Aged; Retrospective Studies; Risk Factors; Survival Rate; Time Factors; Tissue Donors; Treatment Outcome; Young Adult
ISSN:
1399-3046

Full metadata record

DC FieldValue Language
dc.contributor.authorOlaitan, Oyedolamu Ken
dc.contributor.authorZimmermann, Jose Aen
dc.contributor.authorShields, William Pen
dc.contributor.authorRodriguez-Navas, Guillermoen
dc.contributor.authorAwan, Atifen
dc.contributor.authorMohan, Ponnusamyen
dc.contributor.authorLittle, Dilly Men
dc.contributor.authorHickey, David Pen
dc.date.accessioned2011-04-07T08:42:20Z-
dc.date.available2011-04-07T08:42:20Z-
dc.date.issued2010-02-
dc.identifier.citationLong-term outcome of intensive initial immunosuppression protocol in pediatric deceased donor renal transplantation. 2010, 14 (1):87-92 Pediatr Transplanten
dc.identifier.issn1399-3046-
dc.identifier.pmid19309452-
dc.identifier.doi10.1111/j.1399-3046.2009.01138.x-
dc.identifier.urihttp://hdl.handle.net/10147/127618-
dc.description.abstractTo report the long-term outcome of deceased donor kidney transplantation in children with emphasis on the use of an intensive initial immunosuppression protocol using R-ATG as antibody induction. Between January 1991 and December 1997, 82 deceased donor kidney transplantations were performed in 75 pediatric recipients. Mean recipient age at transplantation was 12.9 yr and the mean follow-up period was 12.6 yr. All patients received quadruple immunosuppression with steroid, cyclosporine, azathioprine, and antibody induction using R-ATG-Fresenius. Actual one, five, and 10 yr patient survival rates were 99%, 97%, and 94%, respectively; only one patient (1.2%) developed PTLD. Actual one, five, and 10 yr overall graft survival rates were 84%, 71%, and 50%, respectively; there were five cases (6%) of graft thrombosis and the actual immunological graft survival rates were 91%, 78%, and 63% at one, five, and 10 yr, respectively. The use of an intensive initial immunosuppression protocol with R-ATG as antibody induction is safe and effective in pediatric recipients of deceased donor kidneys with excellent immunological graft survival without an increase in PTLD or other neoplasms over a minimum 10-yr follow up.-
dc.language.isoenen
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshDose-Response Relationship, Drug-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshGraft Rejection-
dc.subject.meshGraft Survival-
dc.subject.meshHumans-
dc.subject.meshImmunosuppression-
dc.subject.meshImmunosuppressive Agents-
dc.subject.meshIreland-
dc.subject.meshKidney Transplantation-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshRetrospective Studies-
dc.subject.meshRisk Factors-
dc.subject.meshSurvival Rate-
dc.subject.meshTime Factors-
dc.subject.meshTissue Donors-
dc.subject.meshTreatment Outcome-
dc.subject.meshYoung Adult-
dc.titleLong-term outcome of intensive initial immunosuppression protocol in pediatric deceased donor renal transplantation.en
dc.typeArticleen
dc.contributor.departmentNational Kidney and Pancreas Transplantation Centre, Beaumont Hospital, Dublin, Ireland. oyedolamu@yahoo.comen
dc.identifier.journalPediatric transplantationen
dc.description.provinceLeinster-

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