Taurine attenuates radiation-induced lung fibrosis in C57/Bl6 fibrosis prone mice.

Hdl Handle:
http://hdl.handle.net/10147/127499
Title:
Taurine attenuates radiation-induced lung fibrosis in C57/Bl6 fibrosis prone mice.
Authors:
Robb, W B; Condron, C; Moriarty, M; Walsh, T N; Bouchier-Hayes, D J
Affiliation:
Department of Surgery, Beaumont Hospital, The Royal College of Surgeons in Ireland, Dublin, Ireland. wrobb@rcsi.ie
Citation:
Taurine attenuates radiation-induced lung fibrosis in C57/Bl6 fibrosis prone mice. 2010, 179 (1):99-105 Ir J Med Sci
Journal:
Irish journal of medical science
Issue Date:
Mar-2010
URI:
http://hdl.handle.net/10147/127499
DOI:
10.1007/s11845-009-0389-2
PubMed ID:
19609640
Abstract:
The amino acid taurine has an established role in attenuating lung fibrosis secondary to bleomycin-induced injury. This study evaluates taurine's effect on TGF-beta1 expression and the development of lung fibrosis after single-dose thoracic radiotherapy.; Four groups of C57/Bl6 mice received 14 Gy thoracic radiation. Mice were treated with taurine or saline supplementation by gavage. After 10 days and 14 weeks of treatment, TGF-beta1 levels were measured in serum and bronchoalveolar lavage fluid (BALF). Lung collagen content was determined using hydroxyproline analysis.; Ten days post radiotherapy, serum TGF-beta1 levels were significantly lower after gavage with taurine rather than saline (P = 0.033). BALF TGF-beta1 at 10 days was also significantly lower in mice treated with taurine (P = 0.031). Hydroxyproline content was also significantly lower at 14 weeks in mice treated with taurine (P = 0.020).; This study presents novel findings of taurine's role in protecting from TGF-beta1-associated development of lung fibrosis after thoracic radiation.
Item Type:
Article
Language:
en
ISSN:
1863-4362

Full metadata record

DC FieldValue Language
dc.contributor.authorRobb, W Ben
dc.contributor.authorCondron, Cen
dc.contributor.authorMoriarty, Men
dc.contributor.authorWalsh, T Nen
dc.contributor.authorBouchier-Hayes, D Jen
dc.date.accessioned2011-04-06T14:44:23Z-
dc.date.available2011-04-06T14:44:23Z-
dc.date.issued2010-03-
dc.identifier.citationTaurine attenuates radiation-induced lung fibrosis in C57/Bl6 fibrosis prone mice. 2010, 179 (1):99-105 Ir J Med Scien
dc.identifier.issn1863-4362-
dc.identifier.pmid19609640-
dc.identifier.doi10.1007/s11845-009-0389-2-
dc.identifier.urihttp://hdl.handle.net/10147/127499-
dc.description.abstractThe amino acid taurine has an established role in attenuating lung fibrosis secondary to bleomycin-induced injury. This study evaluates taurine's effect on TGF-beta1 expression and the development of lung fibrosis after single-dose thoracic radiotherapy.-
dc.description.abstractFour groups of C57/Bl6 mice received 14 Gy thoracic radiation. Mice were treated with taurine or saline supplementation by gavage. After 10 days and 14 weeks of treatment, TGF-beta1 levels were measured in serum and bronchoalveolar lavage fluid (BALF). Lung collagen content was determined using hydroxyproline analysis.-
dc.description.abstractTen days post radiotherapy, serum TGF-beta1 levels were significantly lower after gavage with taurine rather than saline (P = 0.033). BALF TGF-beta1 at 10 days was also significantly lower in mice treated with taurine (P = 0.031). Hydroxyproline content was also significantly lower at 14 weeks in mice treated with taurine (P = 0.020).-
dc.description.abstractThis study presents novel findings of taurine's role in protecting from TGF-beta1-associated development of lung fibrosis after thoracic radiation.-
dc.language.isoenen
dc.titleTaurine attenuates radiation-induced lung fibrosis in C57/Bl6 fibrosis prone mice.en
dc.typeArticleen
dc.contributor.departmentDepartment of Surgery, Beaumont Hospital, The Royal College of Surgeons in Ireland, Dublin, Ireland. wrobb@rcsi.ieen
dc.identifier.journalIrish journal of medical scienceen
dc.description.provinceLeinster-

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