Anaplastic thyroid cancer, tumorigenesis and therapy.

Hdl Handle:
http://hdl.handle.net/10147/127488
Title:
Anaplastic thyroid cancer, tumorigenesis and therapy.
Authors:
O'Neill, J P; Power, D; Condron, C; Bouchier-Hayes, D; Walsh, M
Affiliation:
The Department of Otolaryngology, The Royal College of Surgeons in Ireland, Beaumont Hospital, The Education and Research Building, Beaumont, Dublin 9, Ireland. joneill@rcsi.ie
Citation:
Anaplastic thyroid cancer, tumorigenesis and therapy. 2010, 179 (1):9-15 Ir J Med Sci
Journal:
Irish journal of medical science
Issue Date:
Mar-2010
URI:
http://hdl.handle.net/10147/127488
DOI:
10.1007/s11845-009-0364-y
PubMed ID:
19662494
Abstract:
Anaplastic thyroid cancer (ATC) is a fatal endocrine malignancy. Current therapy fails to significantly improve survival. Recent insights into thyroid tumorigenesis, post-malignant dedifferentiation and mode of metastatic activity offer new therapeutic strategies.; An extensive literature search of Medline and Pubmed was conducted to include all published reports on ATC. Secondary articles were identified from key paper reference listings.; Significant progress, in the last 5 years, has been made outlining thyroid tumorigenesis and the progression to anaplasia. Continued identification and development of drug therapies is required to counter specific molecular targets responsible for the post-malignant dedifferentiation process and ultimately the fatal neoplastic phenotype.
Item Type:
Article
Language:
en
ISSN:
1863-4362

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Neill, J Pen
dc.contributor.authorPower, Den
dc.contributor.authorCondron, Cen
dc.contributor.authorBouchier-Hayes, Den
dc.contributor.authorWalsh, Men
dc.date.accessioned2011-04-06T14:18:33Z-
dc.date.available2011-04-06T14:18:33Z-
dc.date.issued2010-03-
dc.identifier.citationAnaplastic thyroid cancer, tumorigenesis and therapy. 2010, 179 (1):9-15 Ir J Med Scien
dc.identifier.issn1863-4362-
dc.identifier.pmid19662494-
dc.identifier.doi10.1007/s11845-009-0364-y-
dc.identifier.urihttp://hdl.handle.net/10147/127488-
dc.description.abstractAnaplastic thyroid cancer (ATC) is a fatal endocrine malignancy. Current therapy fails to significantly improve survival. Recent insights into thyroid tumorigenesis, post-malignant dedifferentiation and mode of metastatic activity offer new therapeutic strategies.-
dc.description.abstractAn extensive literature search of Medline and Pubmed was conducted to include all published reports on ATC. Secondary articles were identified from key paper reference listings.-
dc.description.abstractSignificant progress, in the last 5 years, has been made outlining thyroid tumorigenesis and the progression to anaplasia. Continued identification and development of drug therapies is required to counter specific molecular targets responsible for the post-malignant dedifferentiation process and ultimately the fatal neoplastic phenotype.-
dc.language.isoenen
dc.titleAnaplastic thyroid cancer, tumorigenesis and therapy.en
dc.typeArticleen
dc.contributor.departmentThe Department of Otolaryngology, The Royal College of Surgeons in Ireland, Beaumont Hospital, The Education and Research Building, Beaumont, Dublin 9, Ireland. joneill@rcsi.ieen
dc.identifier.journalIrish journal of medical scienceen
dc.description.provinceLeinster-

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