The impact of pancreas and kidney transplant on cardiovascular risk factors (analyzed by mode of immunosuppression and exocrine drainage).

Hdl Handle:
http://hdl.handle.net/10147/127437
Title:
The impact of pancreas and kidney transplant on cardiovascular risk factors (analyzed by mode of immunosuppression and exocrine drainage).
Authors:
Davenport, Colin; Hamid, Nadira; O'Sullivan, Eoin P; Daly, Padraig; Mohan, Ponnusamy; Little, Dilly; Thompson, Christopher J; Agha, Amar; Hickey, David; Smith, Diarmuid
Affiliation:
RCSI, Beaumont Endocrinology, Beaumont Hospital, Co Dublin, Ireland. drcdavenport@gmail.com
Citation:
The impact of pancreas and kidney transplant on cardiovascular risk factors (analyzed by mode of immunosuppression and exocrine drainage)., 23 (5):616-20 Clin Transplant
Journal:
Clinical transplantation
Issue Date:
6-Apr-2011
URI:
http://hdl.handle.net/10147/127437
DOI:
10.1111/j.1399-0012.2009.01066.x
PubMed ID:
19732096
Abstract:
The aim of this study was to determine the cardiovascular (CV) risk factor response in Irish patients with type 1 diabetes following simultaneous pancreas and kidney transplantation (SPK), analyzing response based on mode of immunosuppression and surgical drainage in a uniquely homogenous population.; A retrospective review of SPKs carried out between 1993 and 2005 in the National Renal and Pancreatic Centre of Ireland was performed. Weight, glycated hemoglobin (HBA1c), lipid profile, and blood pressure (BP) were measured pre- and post-operatively.; Fifty-eight SPK patients with functioning grafts were analyzed. Thirty-two were male. Following transplantation, mean HbA1c fell from 8.1 (+/-1.5) to 5.2 (+/-0.5)% (p < 0.0001), total cholesterol from 5.2 (+/-1.2) to 4.5 (+/-1.0) mmol/L (p = 0.0004), serum triglycerides from 1.5 (+/-0.6) to 1.1 (+/-0.6) mmol/L (p < 0.0001), and serum creatinine from 699.3 (+/-273.4) to 162.5 (+/-135.8) mmol/L (p < 0.0001). Systolic and diastolic BP fell from 148.5 (+/-23.3) to 136.9 (+/-22.4) mmHg (p = 0.02), and 84.8 (+/-11.7) to 77.8 (+/-10.4) mmHg (p = 0.003), respectively. Cholesterol reduction was significantly greater in the group that received cyclosporine (n = 29) compared with a tacrolimus and mycophenolic acid mofetil (MMF) combination (1.3 +/- 0.3 vs. 0.2 +/- 0.2 mmol/L, p = 0.003). Choice of exocrine vs. endocrine graft drainage did not affect risk factor response.; SPK resulted in significant improvements both in glucose control and other measured CV risk factors.
Item Type:
Article
Language:
en
MeSH:
Adult; Blood Glucose; Cardiovascular Diseases; Cholesterol; Cyclosporine; Diabetes Mellitus, Type 1; Drainage; Female; Graft Rejection; Hemoglobin A, Glycosylated; Humans; Immunosuppressive Agents; Kidney Failure, Chronic; Kidney Transplantation; Male; Mycophenolic Acid; Pancreas Transplantation; Postoperative Complications; Prognosis; Retrospective Studies; Risk Factors; Survival Rate; Tacrolimus; Treatment Outcome; Triglycerides
ISSN:
1399-0012

Full metadata record

DC FieldValue Language
dc.contributor.authorDavenport, Colinen
dc.contributor.authorHamid, Nadiraen
dc.contributor.authorO'Sullivan, Eoin Pen
dc.contributor.authorDaly, Padraigen
dc.contributor.authorMohan, Ponnusamyen
dc.contributor.authorLittle, Dillyen
dc.contributor.authorThompson, Christopher Jen
dc.contributor.authorAgha, Amaren
dc.contributor.authorHickey, Daviden
dc.contributor.authorSmith, Diarmuiden
dc.date.accessioned2011-04-06T14:02:15Z-
dc.date.available2011-04-06T14:02:15Z-
dc.date.issued2011-04-06T14:02:15Z-
dc.identifier.citationThe impact of pancreas and kidney transplant on cardiovascular risk factors (analyzed by mode of immunosuppression and exocrine drainage)., 23 (5):616-20 Clin Transplanten
dc.identifier.issn1399-0012-
dc.identifier.pmid19732096-
dc.identifier.doi10.1111/j.1399-0012.2009.01066.x-
dc.identifier.urihttp://hdl.handle.net/10147/127437-
dc.description.abstractThe aim of this study was to determine the cardiovascular (CV) risk factor response in Irish patients with type 1 diabetes following simultaneous pancreas and kidney transplantation (SPK), analyzing response based on mode of immunosuppression and surgical drainage in a uniquely homogenous population.-
dc.description.abstractA retrospective review of SPKs carried out between 1993 and 2005 in the National Renal and Pancreatic Centre of Ireland was performed. Weight, glycated hemoglobin (HBA1c), lipid profile, and blood pressure (BP) were measured pre- and post-operatively.-
dc.description.abstractFifty-eight SPK patients with functioning grafts were analyzed. Thirty-two were male. Following transplantation, mean HbA1c fell from 8.1 (+/-1.5) to 5.2 (+/-0.5)% (p < 0.0001), total cholesterol from 5.2 (+/-1.2) to 4.5 (+/-1.0) mmol/L (p = 0.0004), serum triglycerides from 1.5 (+/-0.6) to 1.1 (+/-0.6) mmol/L (p < 0.0001), and serum creatinine from 699.3 (+/-273.4) to 162.5 (+/-135.8) mmol/L (p < 0.0001). Systolic and diastolic BP fell from 148.5 (+/-23.3) to 136.9 (+/-22.4) mmHg (p = 0.02), and 84.8 (+/-11.7) to 77.8 (+/-10.4) mmHg (p = 0.003), respectively. Cholesterol reduction was significantly greater in the group that received cyclosporine (n = 29) compared with a tacrolimus and mycophenolic acid mofetil (MMF) combination (1.3 +/- 0.3 vs. 0.2 +/- 0.2 mmol/L, p = 0.003). Choice of exocrine vs. endocrine graft drainage did not affect risk factor response.-
dc.description.abstractSPK resulted in significant improvements both in glucose control and other measured CV risk factors.-
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshBlood Glucose-
dc.subject.meshCardiovascular Diseases-
dc.subject.meshCholesterol-
dc.subject.meshCyclosporine-
dc.subject.meshDiabetes Mellitus, Type 1-
dc.subject.meshDrainage-
dc.subject.meshFemale-
dc.subject.meshGraft Rejection-
dc.subject.meshHemoglobin A, Glycosylated-
dc.subject.meshHumans-
dc.subject.meshImmunosuppressive Agents-
dc.subject.meshKidney Failure, Chronic-
dc.subject.meshKidney Transplantation-
dc.subject.meshMale-
dc.subject.meshMycophenolic Acid-
dc.subject.meshPancreas Transplantation-
dc.subject.meshPostoperative Complications-
dc.subject.meshPrognosis-
dc.subject.meshRetrospective Studies-
dc.subject.meshRisk Factors-
dc.subject.meshSurvival Rate-
dc.subject.meshTacrolimus-
dc.subject.meshTreatment Outcome-
dc.subject.meshTriglycerides-
dc.titleThe impact of pancreas and kidney transplant on cardiovascular risk factors (analyzed by mode of immunosuppression and exocrine drainage).en
dc.typeArticleen
dc.contributor.departmentRCSI, Beaumont Endocrinology, Beaumont Hospital, Co Dublin, Ireland. drcdavenport@gmail.comen
dc.identifier.journalClinical transplantationen
dc.description.provinceLeinster-

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