Below knee angioplasty in elderly patients: Predictors of major adverse clinical outcomes.

Hdl Handle:
http://hdl.handle.net/10147/127272
Title:
Below knee angioplasty in elderly patients: Predictors of major adverse clinical outcomes.
Authors:
Keeling, Aoife N; Khalidi, Karim; Leong, Sum; Wang, Tim T; Ayyoub, Alaa S; McGrath, Frank P; Athanasiou, Thanos; Lee, Michael J
Affiliation:
Department of Academic Radiology, Beaumont Hospital, Beaumont Road, Dublin 9, Ireland.
Citation:
Below knee angioplasty in elderly patients: Predictors of major adverse clinical outcomes. 2011, 77 (3):483-9 Eur J Radiol
Journal:
European journal of radiology
Issue Date:
Mar-2011
URI:
http://hdl.handle.net/10147/127272
DOI:
10.1016/j.ejrad.2009.08.011
PubMed ID:
19765932
Abstract:
To determine predictors of clinical outcome following percutaneous transluminal angioplasty (PTA) in elderly patients with below knee atherosclerotic lesions causing intermittent claudication (IC) or critical limb ischaemia (CLI).; Over 7.5 years, 76 patients (CLI 72%, n=55) underwent below knee PTA. The composite end-point of interest was major adverse clinical outcome (MACO) of the treated limb at follow-up which was defined as clinical failure, need for subsequent endovascular or surgical revascularization or amputation. Actuarial freedom from MACO was assessed using Kaplan-Meier curves and multivariable Cox proportional hazards regression.; IC was improved in 95% at mean 3.4 years (range 0.5-108 months). Successful limb salvage and ulcer healing were seen in 73% with CLI. Most failures were in the CLI group (27% CLI vs. 5% IC), with an amputation rate of 16% for CLI vs. 5% for IC and persistent ulceration in 24% of CLI. Significant independent predictors of MACO were ulceration (hazard ratio 4.02, 95% CI=1.55-10.38) and family history of atherosclerosis (hazard ratio 2.53, 95% CI=1.1-5.92).; Primary below knee PTA is a feasible therapeutic option in this elderly population. Limb ulceration and family history of atherosclerosis may be independent predictors of adverse outcome.
Item Type:
Article In Press
Language:
en
ISSN:
1872-7727

Full metadata record

DC FieldValue Language
dc.contributor.authorKeeling, Aoife Nen
dc.contributor.authorKhalidi, Karimen
dc.contributor.authorLeong, Sumen
dc.contributor.authorWang, Tim Ten
dc.contributor.authorAyyoub, Alaa Sen
dc.contributor.authorMcGrath, Frank Pen
dc.contributor.authorAthanasiou, Thanosen
dc.contributor.authorLee, Michael Jen
dc.date.accessioned2011-04-05T15:32:57Z-
dc.date.available2011-04-05T15:32:57Z-
dc.date.issued2011-03-
dc.identifier.citationBelow knee angioplasty in elderly patients: Predictors of major adverse clinical outcomes. 2011, 77 (3):483-9 Eur J Radiolen
dc.identifier.issn1872-7727-
dc.identifier.pmid19765932-
dc.identifier.doi10.1016/j.ejrad.2009.08.011-
dc.identifier.urihttp://hdl.handle.net/10147/127272-
dc.description.abstractTo determine predictors of clinical outcome following percutaneous transluminal angioplasty (PTA) in elderly patients with below knee atherosclerotic lesions causing intermittent claudication (IC) or critical limb ischaemia (CLI).-
dc.description.abstractOver 7.5 years, 76 patients (CLI 72%, n=55) underwent below knee PTA. The composite end-point of interest was major adverse clinical outcome (MACO) of the treated limb at follow-up which was defined as clinical failure, need for subsequent endovascular or surgical revascularization or amputation. Actuarial freedom from MACO was assessed using Kaplan-Meier curves and multivariable Cox proportional hazards regression.-
dc.description.abstractIC was improved in 95% at mean 3.4 years (range 0.5-108 months). Successful limb salvage and ulcer healing were seen in 73% with CLI. Most failures were in the CLI group (27% CLI vs. 5% IC), with an amputation rate of 16% for CLI vs. 5% for IC and persistent ulceration in 24% of CLI. Significant independent predictors of MACO were ulceration (hazard ratio 4.02, 95% CI=1.55-10.38) and family history of atherosclerosis (hazard ratio 2.53, 95% CI=1.1-5.92).-
dc.description.abstractPrimary below knee PTA is a feasible therapeutic option in this elderly population. Limb ulceration and family history of atherosclerosis may be independent predictors of adverse outcome.-
dc.language.isoenen
dc.titleBelow knee angioplasty in elderly patients: Predictors of major adverse clinical outcomes.en
dc.typeArticle In Pressen
dc.contributor.departmentDepartment of Academic Radiology, Beaumont Hospital, Beaumont Road, Dublin 9, Ireland.en
dc.identifier.journalEuropean journal of radiologyen
dc.description.provinceLeinster-

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