Aldosterone as a renal growth factor.

Hdl Handle:
http://hdl.handle.net/10147/127269
Title:
Aldosterone as a renal growth factor.
Authors:
Thomas, Warren; Dooley, Ruth; Harvey, Brian J
Affiliation:
Department of Molecular Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland. wthomas@rcsi.ie
Citation:
Aldosterone as a renal growth factor., 75 (8-9):550-4 Steroids
Journal:
Steroids
Issue Date:
5-Apr-2011
URI:
http://hdl.handle.net/10147/127269
DOI:
10.1016/j.steroids.2009.09.008
PubMed ID:
19782095
Abstract:
Aldosterone regulates blood pressure through its effects on the cardiovascular system and kidney. Aldosterone can also contribute to the development of hypertension that leads to chronic pathologies such as nephropathy and renal fibrosis. Aldosterone directly modulates renal cell proliferation and differentiation as part of normal kidney development. The stimulation of rapidly activated protein kinase cascades is one facet of how aldosterone regulates renal cell growth. These cascades may also contribute to myofibroblastic transformation and cell proliferation observed in pathological conditions of the kidney. Polycystic kidney disease is a genetic disorder that is accelerated by hypertension. EGFR-dependent proliferation of the renal epithelium is a factor in cyst development and trans-activation of EGFR is a key feature in initiating aldosterone-induced signalling cascades. Delineating the components of aldosterone-induced signalling cascades may identify novel therapeutic targets for proliferative diseases of the kidney.
Item Type:
Article
Language:
en
MeSH:
Aldosterone; Animals; Cell Proliferation; Humans; Kidney; Kidney Diseases; Receptor, Epidermal Growth Factor; Signal Transduction
ISSN:
1878-5867

Full metadata record

DC FieldValue Language
dc.contributor.authorThomas, Warrenen
dc.contributor.authorDooley, Ruthen
dc.contributor.authorHarvey, Brian Jen
dc.date.accessioned2011-04-05T15:26:18Z-
dc.date.available2011-04-05T15:26:18Z-
dc.date.issued2011-04-05T15:26:18Z-
dc.identifier.citationAldosterone as a renal growth factor., 75 (8-9):550-4 Steroidsen
dc.identifier.issn1878-5867-
dc.identifier.pmid19782095-
dc.identifier.doi10.1016/j.steroids.2009.09.008-
dc.identifier.urihttp://hdl.handle.net/10147/127269-
dc.description.abstractAldosterone regulates blood pressure through its effects on the cardiovascular system and kidney. Aldosterone can also contribute to the development of hypertension that leads to chronic pathologies such as nephropathy and renal fibrosis. Aldosterone directly modulates renal cell proliferation and differentiation as part of normal kidney development. The stimulation of rapidly activated protein kinase cascades is one facet of how aldosterone regulates renal cell growth. These cascades may also contribute to myofibroblastic transformation and cell proliferation observed in pathological conditions of the kidney. Polycystic kidney disease is a genetic disorder that is accelerated by hypertension. EGFR-dependent proliferation of the renal epithelium is a factor in cyst development and trans-activation of EGFR is a key feature in initiating aldosterone-induced signalling cascades. Delineating the components of aldosterone-induced signalling cascades may identify novel therapeutic targets for proliferative diseases of the kidney.-
dc.language.isoenen
dc.subject.meshAldosterone-
dc.subject.meshAnimals-
dc.subject.meshCell Proliferation-
dc.subject.meshHumans-
dc.subject.meshKidney-
dc.subject.meshKidney Diseases-
dc.subject.meshReceptor, Epidermal Growth Factor-
dc.subject.meshSignal Transduction-
dc.titleAldosterone as a renal growth factor.en
dc.typeArticleen
dc.contributor.departmentDepartment of Molecular Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland. wthomas@rcsi.ieen
dc.identifier.journalSteroidsen
dc.description.provinceLeinster-

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