Clinical and anatomical heterogeneity in autistic spectrum disorder: a structural MRI study.

Hdl Handle:
http://hdl.handle.net/10147/127227
Title:
Clinical and anatomical heterogeneity in autistic spectrum disorder: a structural MRI study.
Authors:
Toal, F; Daly, E M; Page, L; Deeley, Q; Hallahan, B; Bloemen, O; Cutter, W J; Brammer, M J; Curran, S; Robertson, D; Murphy, C; Murphy, K C; Murphy, D G M
Affiliation:
Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland. ftoal@rcsi.ie
Citation:
Clinical and anatomical heterogeneity in autistic spectrum disorder: a structural MRI study. 2010, 40 (7):1171-81 Psychol Med
Journal:
Psychological medicine
Issue Date:
Jul-2010
URI:
http://hdl.handle.net/10147/127227
DOI:
10.1017/S0033291709991541
PubMed ID:
19891805
Abstract:
Autistic spectrum disorder (ASD) is characterized by stereotyped/obsessional behaviours and social and communicative deficits. However, there is significant variability in the clinical phenotype; for example, people with autism exhibit language delay whereas those with Asperger syndrome do not. It remains unclear whether localized differences in brain anatomy are associated with variation in the clinical phenotype.; We used voxel-based morphometry (VBM) to investigate brain anatomy in adults with ASD. We included 65 adults diagnosed with ASD (39 with Asperger syndrome and 26 with autism) and 33 controls who did not differ significantly in age or gender.; VBM revealed that subjects with ASD had a significant reduction in grey-matter volume of medial temporal, fusiform and cerebellar regions, and in white matter of the brainstem and cerebellar regions. Furthermore, within the subjects with ASD, brain anatomy varied with clinical phenotype. Those with autism demonstrated an increase in grey matter in frontal and temporal lobe regions that was not present in those with Asperger syndrome.; Adults with ASD have significant differences from controls in the anatomy of brain regions implicated in behaviours characterizing the disorder, and this differs according to clinical subtype.
Item Type:
Article
Language:
en
MeSH:
Adolescent; Adult; Asperger Syndrome; Autistic Disorder; Brain; Cognition Disorders; Female; Humans; Language Development Disorders; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Obsessive-Compulsive Disorder; Phenotype; Severity of Illness Index; Stereotypic Movement Disorder; Young Adult
ISSN:
1469-8978

Full metadata record

DC FieldValue Language
dc.contributor.authorToal, Fen
dc.contributor.authorDaly, E Men
dc.contributor.authorPage, Len
dc.contributor.authorDeeley, Qen
dc.contributor.authorHallahan, Ben
dc.contributor.authorBloemen, Oen
dc.contributor.authorCutter, W Jen
dc.contributor.authorBrammer, M Jen
dc.contributor.authorCurran, Sen
dc.contributor.authorRobertson, Den
dc.contributor.authorMurphy, Cen
dc.contributor.authorMurphy, K Cen
dc.contributor.authorMurphy, D G Men
dc.date.accessioned2011-04-05T14:34:56Z-
dc.date.available2011-04-05T14:34:56Z-
dc.date.issued2010-07-
dc.identifier.citationClinical and anatomical heterogeneity in autistic spectrum disorder: a structural MRI study. 2010, 40 (7):1171-81 Psychol Meden
dc.identifier.issn1469-8978-
dc.identifier.pmid19891805-
dc.identifier.doi10.1017/S0033291709991541-
dc.identifier.urihttp://hdl.handle.net/10147/127227-
dc.description.abstractAutistic spectrum disorder (ASD) is characterized by stereotyped/obsessional behaviours and social and communicative deficits. However, there is significant variability in the clinical phenotype; for example, people with autism exhibit language delay whereas those with Asperger syndrome do not. It remains unclear whether localized differences in brain anatomy are associated with variation in the clinical phenotype.-
dc.description.abstractWe used voxel-based morphometry (VBM) to investigate brain anatomy in adults with ASD. We included 65 adults diagnosed with ASD (39 with Asperger syndrome and 26 with autism) and 33 controls who did not differ significantly in age or gender.-
dc.description.abstractVBM revealed that subjects with ASD had a significant reduction in grey-matter volume of medial temporal, fusiform and cerebellar regions, and in white matter of the brainstem and cerebellar regions. Furthermore, within the subjects with ASD, brain anatomy varied with clinical phenotype. Those with autism demonstrated an increase in grey matter in frontal and temporal lobe regions that was not present in those with Asperger syndrome.-
dc.description.abstractAdults with ASD have significant differences from controls in the anatomy of brain regions implicated in behaviours characterizing the disorder, and this differs according to clinical subtype.-
dc.language.isoenen
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAsperger Syndrome-
dc.subject.meshAutistic Disorder-
dc.subject.meshBrain-
dc.subject.meshCognition Disorders-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLanguage Development Disorders-
dc.subject.meshMagnetic Resonance Imaging-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeuropsychological Tests-
dc.subject.meshObsessive-Compulsive Disorder-
dc.subject.meshPhenotype-
dc.subject.meshSeverity of Illness Index-
dc.subject.meshStereotypic Movement Disorder-
dc.subject.meshYoung Adult-
dc.titleClinical and anatomical heterogeneity in autistic spectrum disorder: a structural MRI study.en
dc.typeArticleen
dc.contributor.departmentDepartment of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland. ftoal@rcsi.ieen
dc.identifier.journalPsychological medicineen
dc.description.provinceLeinster-

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