The Irish epilepsy surgery experience: Long-term follow-up.

Hdl Handle:
http://hdl.handle.net/10147/127109
Title:
The Irish epilepsy surgery experience: Long-term follow-up.
Authors:
Dunlea, Orla; Doherty, Colin P; Farrell, Michael; Fitzsimons, Mary; O'Brien, Donncha; Murphy, Kevin; MacMackin, Deirdre; Pender, Niall; Staunton, Hugh; Phillips, Jack; Delanty, Norman
Affiliation:
Department of Neurology, Beaumont Hospital, Dublin 9, Ireland. odunlea@hotmail.com
Citation:
The Irish epilepsy surgery experience: Long-term follow-up. 2010, 19 (4):247-52 Seizure
Journal:
Seizure : the journal of the British Epilepsy Association
Issue Date:
May-2010
URI:
http://hdl.handle.net/10147/127109
DOI:
10.1016/j.seizure.2010.03.001
PubMed ID:
20359911
Abstract:
To assess the long-term seizure outcome of Irish patients who underwent resective surgery for refractory epilepsy since 1975. We also wished to determine the impact of pathology and surgical technique (with particular reference to neocorticectomy) on seizure outcome.; A retrospective review of medical notes, radiological and histopathological records, was undertaken between 1975 and 2005. Missing data was supplemented by telephone calls to patients. One hundred and ninety-nine patients suited the criteria for inclusion and had at least 1-year follow-up (1-24 years, mean 7.0 years). Engel's criteria were used to classify seizure outcome at 1, 2, 5, 10, 15 and >15 years follow-up.; The percentage of patients seizure free at 2, 5, 10, 15 and >15 years were, 56.6%, 41.4%, 44%, 25% and 31.3%, respectively. Of patients with a pathologically confirmed diagnosis of mesial temporal sclerosis, 55.6% were seizure free at 10 years. Equivalent figures for tumour were 62.5%, for cortical dysplasia, 34.8%, for those without any demonstrable pathologic abnormality, 50%, for dual pathology, 50% and for all others, 33.3%. Of those with 10 years or greater follow-up only 20% of neocorticectomy patients were in Engel class 1, compared with an average of 58.5% for the other surgical techniques.; Seizure freedom rates for Irish Patients were comparable to other large retrospective studies. Patients who underwent selective procedures tended to do better than those undergoing lobar resections, in keeping with international trends. The surgical technique unique to the Irish cohort, temporal necocorticectomy, had the worst long-term outcome.
Item Type:
Article
Language:
en
MeSH:
Adolescent; Adult; Anterior Temporal Lobectomy; Child; Child, Preschool; Epilepsy; Female; Follow-Up Studies; Humans; Infant; Ireland; Male; Middle Aged; Neurosurgical Procedures; Retrospective Studies; Seizures; Treatment Outcome; Young Adult
ISSN:
1532-2688

Full metadata record

DC FieldValue Language
dc.contributor.authorDunlea, Orlaen
dc.contributor.authorDoherty, Colin Pen
dc.contributor.authorFarrell, Michaelen
dc.contributor.authorFitzsimons, Maryen
dc.contributor.authorO'Brien, Donnchaen
dc.contributor.authorMurphy, Kevinen
dc.contributor.authorMacMackin, Deirdreen
dc.contributor.authorPender, Niallen
dc.contributor.authorStaunton, Hughen
dc.contributor.authorPhillips, Jacken
dc.contributor.authorDelanty, Normanen
dc.date.accessioned2011-04-05T09:55:32Z-
dc.date.available2011-04-05T09:55:32Z-
dc.date.issued2010-05-
dc.identifier.citationThe Irish epilepsy surgery experience: Long-term follow-up. 2010, 19 (4):247-52 Seizureen
dc.identifier.issn1532-2688-
dc.identifier.pmid20359911-
dc.identifier.doi10.1016/j.seizure.2010.03.001-
dc.identifier.urihttp://hdl.handle.net/10147/127109-
dc.description.abstractTo assess the long-term seizure outcome of Irish patients who underwent resective surgery for refractory epilepsy since 1975. We also wished to determine the impact of pathology and surgical technique (with particular reference to neocorticectomy) on seizure outcome.-
dc.description.abstractA retrospective review of medical notes, radiological and histopathological records, was undertaken between 1975 and 2005. Missing data was supplemented by telephone calls to patients. One hundred and ninety-nine patients suited the criteria for inclusion and had at least 1-year follow-up (1-24 years, mean 7.0 years). Engel's criteria were used to classify seizure outcome at 1, 2, 5, 10, 15 and >15 years follow-up.-
dc.description.abstractThe percentage of patients seizure free at 2, 5, 10, 15 and >15 years were, 56.6%, 41.4%, 44%, 25% and 31.3%, respectively. Of patients with a pathologically confirmed diagnosis of mesial temporal sclerosis, 55.6% were seizure free at 10 years. Equivalent figures for tumour were 62.5%, for cortical dysplasia, 34.8%, for those without any demonstrable pathologic abnormality, 50%, for dual pathology, 50% and for all others, 33.3%. Of those with 10 years or greater follow-up only 20% of neocorticectomy patients were in Engel class 1, compared with an average of 58.5% for the other surgical techniques.-
dc.description.abstractSeizure freedom rates for Irish Patients were comparable to other large retrospective studies. Patients who underwent selective procedures tended to do better than those undergoing lobar resections, in keeping with international trends. The surgical technique unique to the Irish cohort, temporal necocorticectomy, had the worst long-term outcome.-
dc.language.isoenen
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAnterior Temporal Lobectomy-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshEpilepsy-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshHumans-
dc.subject.meshInfant-
dc.subject.meshIreland-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeurosurgical Procedures-
dc.subject.meshRetrospective Studies-
dc.subject.meshSeizures-
dc.subject.meshTreatment Outcome-
dc.subject.meshYoung Adult-
dc.titleThe Irish epilepsy surgery experience: Long-term follow-up.en
dc.typeArticleen
dc.contributor.departmentDepartment of Neurology, Beaumont Hospital, Dublin 9, Ireland. odunlea@hotmail.comen
dc.identifier.journalSeizure : the journal of the British Epilepsy Associationen
dc.description.provinceLeinster-

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