Felbamate in an adult population with severe refractory epilepsy.

Hdl Handle:
http://hdl.handle.net/10147/127093
Title:
Felbamate in an adult population with severe refractory epilepsy.
Authors:
Kearney, H; Delanty, N
Affiliation:
Department of Neurology, Beaumont Hospital, Beaumont, Dublin. hughkearney@yahoo.com
Citation:
Felbamate in an adult population with severe refractory epilepsy., 102 (10):326-8 Ir Med J
Journal:
Irish medical journal
Issue Date:
5-Apr-2011
URI:
http://hdl.handle.net/10147/127093
PubMed ID:
20108801
Abstract:
Felbamate (FBM) is efficacious in treating patients with refractory epilepsy but was withdrawn due to cases of aplastic anaemia, hepatic failure and five reported deaths. FBM is currently used in specialist centres and is only being used in one Irish centre to date. This papers aim is to review the efficacy and safety experience of FBM in Irish adult patients with refractory epilepsy. A retrospective chart review was done on patients' medical records. Patients were subdivided into responders and non responders based on change in seizure frequency and side effects were recorded for all. Of the 13 patients on FBM nine patients responded to FBM, four patients did not. FBM is a safe and efficacious alternative in an Irish adult population with refractory epilepsy. However close monitoring is still required given the potential fatal side effects that are possible with this anticonvulsant.
Item Type:
Article
Language:
en
MeSH:
Adult; Anticonvulsants; Epilepsy; Female; Humans; Ireland; Male; Middle Aged; Phenylcarbamates; Propylene Glycols; Retrospective Studies; Treatment Outcome
ISSN:
0332-3102

Full metadata record

DC FieldValue Language
dc.contributor.authorKearney, Hen
dc.contributor.authorDelanty, Nen
dc.date.accessioned2011-04-05T11:15:56Z-
dc.date.available2011-04-05T11:15:56Z-
dc.date.issued2011-04-05T11:15:56Z-
dc.identifier.citationFelbamate in an adult population with severe refractory epilepsy., 102 (10):326-8 Ir Med Jen
dc.identifier.issn0332-3102-
dc.identifier.pmid20108801-
dc.identifier.urihttp://hdl.handle.net/10147/127093-
dc.description.abstractFelbamate (FBM) is efficacious in treating patients with refractory epilepsy but was withdrawn due to cases of aplastic anaemia, hepatic failure and five reported deaths. FBM is currently used in specialist centres and is only being used in one Irish centre to date. This papers aim is to review the efficacy and safety experience of FBM in Irish adult patients with refractory epilepsy. A retrospective chart review was done on patients' medical records. Patients were subdivided into responders and non responders based on change in seizure frequency and side effects were recorded for all. Of the 13 patients on FBM nine patients responded to FBM, four patients did not. FBM is a safe and efficacious alternative in an Irish adult population with refractory epilepsy. However close monitoring is still required given the potential fatal side effects that are possible with this anticonvulsant.-
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshAnticonvulsants-
dc.subject.meshEpilepsy-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshIreland-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshPhenylcarbamates-
dc.subject.meshPropylene Glycols-
dc.subject.meshRetrospective Studies-
dc.subject.meshTreatment Outcome-
dc.titleFelbamate in an adult population with severe refractory epilepsy.en
dc.typeArticleen
dc.contributor.departmentDepartment of Neurology, Beaumont Hospital, Beaumont, Dublin. hughkearney@yahoo.comen
dc.identifier.journalIrish medical journalen
dc.description.provinceLeinster-

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