The role of menin in parathyroid tumorigenesis.

Hdl Handle:
http://hdl.handle.net/10147/127088
Title:
The role of menin in parathyroid tumorigenesis.
Authors:
Davenport, Colin; Agha, Amar
Affiliation:
Academic Department of Endocrinology, Beaumont Hospital and Royal College of Surgeons in Ireland Medical School, Beaumont Road, Dublin 9, Ireland.
Citation:
The role of menin in parathyroid tumorigenesis. 2009, 668:79-86 Adv. Exp. Med. Biol.
Journal:
Advances in experimental medicine and biology
Issue Date:
2009
URI:
http://hdl.handle.net/10147/127088
PubMed ID:
20175455
Abstract:
Primary hyperparathyroidism is a common disorder that involves the pathological enlargement of one or more parathyroid glands resulting in excessive production of parathyroid hormone (PTH). The exact pathogenesis of this disease remains to be fully understood. In recent years interest has focussed on the interaction between menin protein and the transforming growth factor (TGF)-beta/Smad signalling pathway. In vitro experimentation has demonstrated that the presence of menin is required for TGF-beta to effectively inhibit parathyroid cell proliferation and PTH production. This observation correlates with the almost universal occurrence of parathyroid tumors accompanying the inactivation of menin in multiple endocrine neoplasia Type 1 (MEN1) syndrome and the high rate of somatic menin gene mutations seen in sporadic parathyroid adenomas. This chapter aims to review the role of menin in primary hyperparathyroidism and parathyroid hormone-regulation, including the influences of MEN1 gene mutations on parathyroid cell proliferation, differentiation and tumorigenesis.
Item Type:
Article
Language:
en
MeSH:
Humans; Hyperparathyroidism, Primary; Multiple Endocrine Neoplasia Type 1; Mutation; Parathyroid Glands; Parathyroid Hormone; Parathyroid Neoplasms; Proto-Oncogene Proteins; Signal Transduction; Smad Proteins; Transforming Growth Factor beta
ISSN:
0065-2598

Full metadata record

DC FieldValue Language
dc.contributor.authorDavenport, Colinen
dc.contributor.authorAgha, Amaren
dc.date.accessioned2011-04-05T10:16:19Z-
dc.date.available2011-04-05T10:16:19Z-
dc.date.issued2009-
dc.identifier.citationThe role of menin in parathyroid tumorigenesis. 2009, 668:79-86 Adv. Exp. Med. Biol.en
dc.identifier.issn0065-2598-
dc.identifier.pmid20175455-
dc.identifier.urihttp://hdl.handle.net/10147/127088-
dc.description.abstractPrimary hyperparathyroidism is a common disorder that involves the pathological enlargement of one or more parathyroid glands resulting in excessive production of parathyroid hormone (PTH). The exact pathogenesis of this disease remains to be fully understood. In recent years interest has focussed on the interaction between menin protein and the transforming growth factor (TGF)-beta/Smad signalling pathway. In vitro experimentation has demonstrated that the presence of menin is required for TGF-beta to effectively inhibit parathyroid cell proliferation and PTH production. This observation correlates with the almost universal occurrence of parathyroid tumors accompanying the inactivation of menin in multiple endocrine neoplasia Type 1 (MEN1) syndrome and the high rate of somatic menin gene mutations seen in sporadic parathyroid adenomas. This chapter aims to review the role of menin in primary hyperparathyroidism and parathyroid hormone-regulation, including the influences of MEN1 gene mutations on parathyroid cell proliferation, differentiation and tumorigenesis.-
dc.language.isoenen
dc.subject.meshHumans-
dc.subject.meshHyperparathyroidism, Primary-
dc.subject.meshMultiple Endocrine Neoplasia Type 1-
dc.subject.meshMutation-
dc.subject.meshParathyroid Glands-
dc.subject.meshParathyroid Hormone-
dc.subject.meshParathyroid Neoplasms-
dc.subject.meshProto-Oncogene Proteins-
dc.subject.meshSignal Transduction-
dc.subject.meshSmad Proteins-
dc.subject.meshTransforming Growth Factor beta-
dc.titleThe role of menin in parathyroid tumorigenesis.en
dc.typeArticleen
dc.contributor.departmentAcademic Department of Endocrinology, Beaumont Hospital and Royal College of Surgeons in Ireland Medical School, Beaumont Road, Dublin 9, Ireland.en
dc.identifier.journalAdvances in experimental medicine and biologyen
dc.description.provinceLeinster-

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