EBV-positive B cell cerebral lymphoma 12 years after sex-mismatched kidney transplantation: post-transplant lymphoproliferative disorder or donor-derived lymphoma?

Hdl Handle:
http://hdl.handle.net/10147/127086
Title:
EBV-positive B cell cerebral lymphoma 12 years after sex-mismatched kidney transplantation: post-transplant lymphoproliferative disorder or donor-derived lymphoma?
Authors:
Phelan, Paul J; Murphy, Rory K J; Farrell, Michael; O'Toole, Orna; Heffernan, Josie; O'Brien, Donncha; Breathnach, Oscar; Conlon, Peter J
Affiliation:
Department of Nephrology, Beaumont Hospital, Dublin, Ireland. paulphel@gmail.com
Citation:
EBV-positive B cell cerebral lymphoma 12 years after sex-mismatched kidney transplantation: post-transplant lymphoproliferative disorder or donor-derived lymphoma? 2010, 25 (6):2032-5 Nephrol. Dial. Transplant.
Journal:
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Issue Date:
Jun-2010
URI:
http://hdl.handle.net/10147/127086
DOI:
10.1093/ndt/gfq170
PubMed ID:
20348150
Abstract:
We present a follow-up case report of possible transmission of lymphoma 12 years after deceased-donor renal transplantation from a male donor who was found at autopsy to have had an occult lymphoma. The female recipient underwent prompt transplant nephrectomy. However, 12 years later, she presented with cerebral B cell lymphoma. A donor origin for the cerebral lymphoma was supported by in situ hybridization demonstration of a Y chromosome in the lymphoma. There was a dramatic resolution of the cerebral lesions with tapering of immunosuppression and introduction of rituximab treatment. The finding of a Y chromosome in the cerebral lymphoma does not exclude a host contribution to lymphoma development.
Item Type:
Article
Language:
en
MeSH:
Adult; Brain Neoplasms; Chromosomes, Human, Y; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; In Situ Hybridization; Kidney Transplantation; Lymphoma, B-Cell; Lymphoproliferative Disorders; Male; Middle Aged; Time Factors; Tissue Donors
ISSN:
1460-2385

Full metadata record

DC FieldValue Language
dc.contributor.authorPhelan, Paul Jen
dc.contributor.authorMurphy, Rory K Jen
dc.contributor.authorFarrell, Michaelen
dc.contributor.authorO'Toole, Ornaen
dc.contributor.authorHeffernan, Josieen
dc.contributor.authorO'Brien, Donnchaen
dc.contributor.authorBreathnach, Oscaren
dc.contributor.authorConlon, Peter Jen
dc.date.accessioned2011-04-05T10:00:13Z-
dc.date.available2011-04-05T10:00:13Z-
dc.date.issued2010-06-
dc.identifier.citationEBV-positive B cell cerebral lymphoma 12 years after sex-mismatched kidney transplantation: post-transplant lymphoproliferative disorder or donor-derived lymphoma? 2010, 25 (6):2032-5 Nephrol. Dial. Transplant.en
dc.identifier.issn1460-2385-
dc.identifier.pmid20348150-
dc.identifier.doi10.1093/ndt/gfq170-
dc.identifier.urihttp://hdl.handle.net/10147/127086-
dc.description.abstractWe present a follow-up case report of possible transmission of lymphoma 12 years after deceased-donor renal transplantation from a male donor who was found at autopsy to have had an occult lymphoma. The female recipient underwent prompt transplant nephrectomy. However, 12 years later, she presented with cerebral B cell lymphoma. A donor origin for the cerebral lymphoma was supported by in situ hybridization demonstration of a Y chromosome in the lymphoma. There was a dramatic resolution of the cerebral lesions with tapering of immunosuppression and introduction of rituximab treatment. The finding of a Y chromosome in the cerebral lymphoma does not exclude a host contribution to lymphoma development.-
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshBrain Neoplasms-
dc.subject.meshChromosomes, Human, Y-
dc.subject.meshEpstein-Barr Virus Infections-
dc.subject.meshFemale-
dc.subject.meshHerpesvirus 4, Human-
dc.subject.meshHumans-
dc.subject.meshIn Situ Hybridization-
dc.subject.meshKidney Transplantation-
dc.subject.meshLymphoma, B-Cell-
dc.subject.meshLymphoproliferative Disorders-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshTime Factors-
dc.subject.meshTissue Donors-
dc.titleEBV-positive B cell cerebral lymphoma 12 years after sex-mismatched kidney transplantation: post-transplant lymphoproliferative disorder or donor-derived lymphoma?en
dc.typeArticleen
dc.contributor.departmentDepartment of Nephrology, Beaumont Hospital, Dublin, Ireland. paulphel@gmail.comen
dc.identifier.journalNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Associationen
dc.description.provinceLeinster-
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