Cerebral tuberculoma in a patient receiving anti-TNF alpha (adalimumab) treatment.

Hdl Handle:
http://hdl.handle.net/10147/126567
Title:
Cerebral tuberculoma in a patient receiving anti-TNF alpha (adalimumab) treatment.
Authors:
Lynch, Karen; Farrell, Michael
Affiliation:
Department of Neuropathology, Beaumont Hospital, Beaumont, Dublin 9, Ireland. karenlynch81@gmail.com
Citation:
Cerebral tuberculoma in a patient receiving anti-TNF alpha (adalimumab) treatment. 2010, 29 (10):1201-4 Clin. Rheumatol.
Journal:
Clinical rheumatology
Issue Date:
Oct-2010
URI:
http://hdl.handle.net/10147/126567
DOI:
10.1007/s10067-010-1466-7
PubMed ID:
20419463
Abstract:
We report a case of a cerebral tuberculoma in a 60-year-old woman with rheumatoid arthritis while receiving the anti-tumor necrosis factor alpha monoclonal antibody, adalimumab (Humira), for active disease. MR brain imaging for dyspraxia revealed a left parietal ring-enhancing lesion, which on resection was shown to be a necrotizing granuloma. There were no associated pulmonary lesions, and the patient was systemically well. Sputum and urine cultures were negative for tuberculosis. The patient was treated with anti-tuberculous medications and made an excellent recovery. We consider this to be the first documented case of tuberculosis involving the central nervous system occurring in the setting of adalimumab treatment.
Item Type:
Article
Language:
en
MeSH:
Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Brain Diseases; Female; Humans; Middle Aged; Parietal Lobe; Treatment Outcome; Tuberculoma, Intracranial
ISSN:
1434-9949

Full metadata record

DC FieldValue Language
dc.contributor.authorLynch, Karenen
dc.contributor.authorFarrell, Michaelen
dc.date.accessioned2011-03-31T12:55:23Z-
dc.date.available2011-03-31T12:55:23Z-
dc.date.issued2010-10-
dc.identifier.citationCerebral tuberculoma in a patient receiving anti-TNF alpha (adalimumab) treatment. 2010, 29 (10):1201-4 Clin. Rheumatol.en
dc.identifier.issn1434-9949-
dc.identifier.pmid20419463-
dc.identifier.doi10.1007/s10067-010-1466-7-
dc.identifier.urihttp://hdl.handle.net/10147/126567-
dc.description.abstractWe report a case of a cerebral tuberculoma in a 60-year-old woman with rheumatoid arthritis while receiving the anti-tumor necrosis factor alpha monoclonal antibody, adalimumab (Humira), for active disease. MR brain imaging for dyspraxia revealed a left parietal ring-enhancing lesion, which on resection was shown to be a necrotizing granuloma. There were no associated pulmonary lesions, and the patient was systemically well. Sputum and urine cultures were negative for tuberculosis. The patient was treated with anti-tuberculous medications and made an excellent recovery. We consider this to be the first documented case of tuberculosis involving the central nervous system occurring in the setting of adalimumab treatment.-
dc.language.isoenen
dc.subject.meshAntibodies, Monoclonal-
dc.subject.meshAntirheumatic Agents-
dc.subject.meshArthritis, Rheumatoid-
dc.subject.meshBrain Diseases-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMiddle Aged-
dc.subject.meshParietal Lobe-
dc.subject.meshTreatment Outcome-
dc.subject.meshTuberculoma, Intracranial-
dc.titleCerebral tuberculoma in a patient receiving anti-TNF alpha (adalimumab) treatment.en
dc.typeArticleen
dc.contributor.departmentDepartment of Neuropathology, Beaumont Hospital, Beaumont, Dublin 9, Ireland. karenlynch81@gmail.comen
dc.identifier.journalClinical rheumatologyen
dc.description.provinceLeinster-
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