The interaction between growth hormone and the thyroid axis in hypopituitary patients.

Hdl Handle:
http://hdl.handle.net/10147/126566
Title:
The interaction between growth hormone and the thyroid axis in hypopituitary patients.
Authors:
Behan, Lucy Ann; Monson, John P; Agha, Amar
Affiliation:
Academic Department of Endocrinology, Beaumont Hospital, Dublin, Ireland.
Citation:
The interaction between growth hormone and the thyroid axis in hypopituitary patients. 2011, 74 (3):281-8 Clin. Endocrinol. (Oxf)
Journal:
Clinical endocrinology
Issue Date:
Mar-2011
URI:
http://hdl.handle.net/10147/126566
DOI:
10.1111/j.1365-2265.2010.03815.x
PubMed ID:
20455887
Abstract:
Alterations in the hypothalamo-pituitary-thyroid axis have been reported following growth hormone (GH) administration in both adults and children with and without growth hormone deficiency. Reductions in serum free thyroxine (T4), increased tri-iodothyronine (T3) with or without a reduction in serum thyroid-stimulating hormone secretion have been reported following GH replacement, but there are wide inconsistencies in the literature about these perturbations. The clinical significance of these changes in thyroid function remains uncertain. Some authors report the changes are transient and revert to normal after a few months or longer. However, in adult hypopituitary patients, GH replacement has been reported to unmask central hypothyroidism biochemically in 36-47% of apparently euthyroid patients, necessitating thyroxine replacement and resulting in an attenuation of the benefit of GH replacement on quality of life in those who became biochemically hypothyroid after GH replacement. The group at highest risk are those with organic pituitary disease or multiple pituitary hormone deficiencies. It is therefore prudent to monitor thyroid function in hypopituitary patients starting GH therapy to identify those who will develop clinical and biochemical features of central hypothyroidism, thus facilitating optimal and timely replacement.
Item Type:
Article
Language:
en
ISSN:
1365-2265

Full metadata record

DC FieldValue Language
dc.contributor.authorBehan, Lucy Annen
dc.contributor.authorMonson, John Pen
dc.contributor.authorAgha, Amaren
dc.date.accessioned2011-03-31T12:50:50Z-
dc.date.available2011-03-31T12:50:50Z-
dc.date.issued2011-03-
dc.identifier.citationThe interaction between growth hormone and the thyroid axis in hypopituitary patients. 2011, 74 (3):281-8 Clin. Endocrinol. (Oxf)en
dc.identifier.issn1365-2265-
dc.identifier.pmid20455887-
dc.identifier.doi10.1111/j.1365-2265.2010.03815.x-
dc.identifier.urihttp://hdl.handle.net/10147/126566-
dc.description.abstractAlterations in the hypothalamo-pituitary-thyroid axis have been reported following growth hormone (GH) administration in both adults and children with and without growth hormone deficiency. Reductions in serum free thyroxine (T4), increased tri-iodothyronine (T3) with or without a reduction in serum thyroid-stimulating hormone secretion have been reported following GH replacement, but there are wide inconsistencies in the literature about these perturbations. The clinical significance of these changes in thyroid function remains uncertain. Some authors report the changes are transient and revert to normal after a few months or longer. However, in adult hypopituitary patients, GH replacement has been reported to unmask central hypothyroidism biochemically in 36-47% of apparently euthyroid patients, necessitating thyroxine replacement and resulting in an attenuation of the benefit of GH replacement on quality of life in those who became biochemically hypothyroid after GH replacement. The group at highest risk are those with organic pituitary disease or multiple pituitary hormone deficiencies. It is therefore prudent to monitor thyroid function in hypopituitary patients starting GH therapy to identify those who will develop clinical and biochemical features of central hypothyroidism, thus facilitating optimal and timely replacement.-
dc.language.isoenen
dc.titleThe interaction between growth hormone and the thyroid axis in hypopituitary patients.en
dc.typeArticleen
dc.contributor.departmentAcademic Department of Endocrinology, Beaumont Hospital, Dublin, Ireland.en
dc.identifier.journalClinical endocrinologyen
dc.description.provinceLeinster-

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