Iodinated contrast media alter immune responses in pro-inflammatory states.

Hdl Handle:
http://hdl.handle.net/10147/126507
Title:
Iodinated contrast media alter immune responses in pro-inflammatory states.
Authors:
O'Donnell, David H; Moloney, Michael A; Bouchier-Hayes, David J; Lee, Michael J
Affiliation:
Department of Radiology and Vascular Surgery, Beaumont Hospital and Royal College of Surgeons in Ireland, Dublin, Ireland.
Citation:
Iodinated contrast media alter immune responses in pro-inflammatory states. 2010, 51 (6):635-40 Acta Radiol
Journal:
Acta radiologica (Stockholm, Sweden : 1987)
Issue Date:
Jul-2010
URI:
http://hdl.handle.net/10147/126507
DOI:
10.3109/02841851.2010.481679
PubMed ID:
20528648
Abstract:
Hypertonic saline causes a transient elevation of blood osmolality and has been shown to alter cellular inflammatory responses in pro-inflammatory states. Intravascular administration of iodine contrast media also causes a transient elevation of blood osmolarity.; To investigate the effect of iodine contrast media on leukocyte-endothelial interaction in vivo using intravital microscopy.; Male Sprague-Dawley rats (n=36) were randomized into six groups and were treated with: saline, high osmolar contrast medium, low osmolar contrast medium, and endotoxin alone and in combination with the high and low osmolar contrast media. The effect on leukocyte-endothelial interaction in the post-mesenteric venules was observed using the technique of intravital microscopy. The sequence of leukocyte rolling velocity, leukocyte-endothelial cell adherence, and transmigration was recorded and analyzed at 10 min intervals to a maximum of 120 min.; Endotoxin significantly decreased the rolling velocity and increased the adherence and transmigration of leukocytes in a time-dependent manner. Both types of iodine contrast media attenuated this pro-inflammatory response to endotoxin. This effect began between 60 and 70 min after the onset of the experiment.; Hyperosmolar and lower osmolar iodine contrast media attenuate the pro-inflammatory leukocyte-endothelial response to endotoxin in vivo.
Item Type:
Article
Language:
en
MeSH:
Animals; Cell Adhesion; Contrast Media; Endothelial Cells; Endotoxins; Halogenation; Immunity, Cellular; Inflammation; Iodine; Leukocytes; Male; Osmolar Concentration; Rats; Rats, Sprague-Dawley
ISSN:
1600-0455

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Donnell, David Hen
dc.contributor.authorMoloney, Michael Aen
dc.contributor.authorBouchier-Hayes, David Jen
dc.contributor.authorLee, Michael Jen
dc.date.accessioned2011-03-31T09:37:07Z-
dc.date.available2011-03-31T09:37:07Z-
dc.date.issued2010-07-
dc.identifier.citationIodinated contrast media alter immune responses in pro-inflammatory states. 2010, 51 (6):635-40 Acta Radiolen
dc.identifier.issn1600-0455-
dc.identifier.pmid20528648-
dc.identifier.doi10.3109/02841851.2010.481679-
dc.identifier.urihttp://hdl.handle.net/10147/126507-
dc.description.abstractHypertonic saline causes a transient elevation of blood osmolality and has been shown to alter cellular inflammatory responses in pro-inflammatory states. Intravascular administration of iodine contrast media also causes a transient elevation of blood osmolarity.-
dc.description.abstractTo investigate the effect of iodine contrast media on leukocyte-endothelial interaction in vivo using intravital microscopy.-
dc.description.abstractMale Sprague-Dawley rats (n=36) were randomized into six groups and were treated with: saline, high osmolar contrast medium, low osmolar contrast medium, and endotoxin alone and in combination with the high and low osmolar contrast media. The effect on leukocyte-endothelial interaction in the post-mesenteric venules was observed using the technique of intravital microscopy. The sequence of leukocyte rolling velocity, leukocyte-endothelial cell adherence, and transmigration was recorded and analyzed at 10 min intervals to a maximum of 120 min.-
dc.description.abstractEndotoxin significantly decreased the rolling velocity and increased the adherence and transmigration of leukocytes in a time-dependent manner. Both types of iodine contrast media attenuated this pro-inflammatory response to endotoxin. This effect began between 60 and 70 min after the onset of the experiment.-
dc.description.abstractHyperosmolar and lower osmolar iodine contrast media attenuate the pro-inflammatory leukocyte-endothelial response to endotoxin in vivo.-
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshCell Adhesion-
dc.subject.meshContrast Media-
dc.subject.meshEndothelial Cells-
dc.subject.meshEndotoxins-
dc.subject.meshHalogenation-
dc.subject.meshImmunity, Cellular-
dc.subject.meshInflammation-
dc.subject.meshIodine-
dc.subject.meshLeukocytes-
dc.subject.meshMale-
dc.subject.meshOsmolar Concentration-
dc.subject.meshRats-
dc.subject.meshRats, Sprague-Dawley-
dc.titleIodinated contrast media alter immune responses in pro-inflammatory states.en
dc.typeArticleen
dc.contributor.departmentDepartment of Radiology and Vascular Surgery, Beaumont Hospital and Royal College of Surgeons in Ireland, Dublin, Ireland.en
dc.identifier.journalActa radiologica (Stockholm, Sweden : 1987)en
dc.description.provinceLeinster-

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