The impact of peritransplant warfarin use on renal transplant outcome.

Hdl Handle:
http://hdl.handle.net/10147/126493
Title:
The impact of peritransplant warfarin use on renal transplant outcome.
Authors:
Connaughton, Dervla M; Phelan, Paul J; Scheult, Jansen; Ma'ayeh, Marwan; O'Kelly, Patrick; Walshe, Joseph J; Magee, Colm; Little, Dilly; Hickey, David; Slaby, Jiri; Conlon, Peter J
Affiliation:
Department of Nephrology, Beaumont Hospital, Dublin, Ireland.
Citation:
The impact of peritransplant warfarin use on renal transplant outcome., 23 (5):587-92 J. Nephrol.
Journal:
Journal of nephrology
Issue Date:
31-Mar-2011
URI:
http://hdl.handle.net/10147/126493
PubMed ID:
20540039
Additional Links:
http://www.jnephrol.com/public/JN/Article/Article.aspx?UidArticle=FAD65BCB-4BFE-4672-95F9-24D196CFAFAE
Abstract:
The unplanned nature of kidney transplantation necessitates that patients undergo surgery without prior cessation of warfarin. Our study analyses the impact of warfarin treatment in the peritransplant period on graft outcome and perioperative transfusion requirements.; We identified 31 patients undergoing deceased donor kidney transplantation who were concurrently receiving warfarin therapy, between 2000 and 2008. A random, sex-matched, adult, deceased donor control group of 62 patients was generated from the Irish transplant database.; The warfarin group were older (mean 47.5 vs. 42.5 years, p=0.067) and had spent longer on dialysis prior to transplantation (mean 3.5 vs. 2.1 years, p=0.004). Graft survival in the warfarin group was not significantly different at 1-, 3- and 5-year follow-ups. There was no statistically significant difference in red blood cell transfusions between the groups (45% vs. 29%, p=0.2). Warfarin patients had a prolonged mean cold ischaemia time (22.3 vs. 18.5 hours, p=0.002).; This study demonstrates excellent short- and long-term results for kidney transplantation in patients requiring warfarin at the time of transplantation.
Item Type:
Article
Language:
en
MeSH:
Adult; Anticoagulants; Female; Hemoglobins; Humans; Kidney Transplantation; Male; Middle Aged; Retrospective Studies; Transplantation, Homologous; Treatment Outcome; Warfarin
ISSN:
1121-8428

Full metadata record

DC FieldValue Language
dc.contributor.authorConnaughton, Dervla Men
dc.contributor.authorPhelan, Paul Jen
dc.contributor.authorScheult, Jansenen
dc.contributor.authorMa'ayeh, Marwanen
dc.contributor.authorO'Kelly, Patricken
dc.contributor.authorWalshe, Joseph Jen
dc.contributor.authorMagee, Colmen
dc.contributor.authorLittle, Dillyen
dc.contributor.authorHickey, Daviden
dc.contributor.authorSlaby, Jirien
dc.contributor.authorConlon, Peter Jen
dc.date.accessioned2011-03-31T09:36:07Z-
dc.date.available2011-03-31T09:36:07Z-
dc.date.issued2011-03-31T09:36:07Z-
dc.identifier.citationThe impact of peritransplant warfarin use on renal transplant outcome., 23 (5):587-92 J. Nephrol.en
dc.identifier.issn1121-8428-
dc.identifier.pmid20540039-
dc.identifier.urihttp://hdl.handle.net/10147/126493-
dc.description.abstractThe unplanned nature of kidney transplantation necessitates that patients undergo surgery without prior cessation of warfarin. Our study analyses the impact of warfarin treatment in the peritransplant period on graft outcome and perioperative transfusion requirements.-
dc.description.abstractWe identified 31 patients undergoing deceased donor kidney transplantation who were concurrently receiving warfarin therapy, between 2000 and 2008. A random, sex-matched, adult, deceased donor control group of 62 patients was generated from the Irish transplant database.-
dc.description.abstractThe warfarin group were older (mean 47.5 vs. 42.5 years, p=0.067) and had spent longer on dialysis prior to transplantation (mean 3.5 vs. 2.1 years, p=0.004). Graft survival in the warfarin group was not significantly different at 1-, 3- and 5-year follow-ups. There was no statistically significant difference in red blood cell transfusions between the groups (45% vs. 29%, p=0.2). Warfarin patients had a prolonged mean cold ischaemia time (22.3 vs. 18.5 hours, p=0.002).-
dc.description.abstractThis study demonstrates excellent short- and long-term results for kidney transplantation in patients requiring warfarin at the time of transplantation.-
dc.language.isoenen
dc.relation.urlhttp://www.jnephrol.com/public/JN/Article/Article.aspx?UidArticle=FAD65BCB-4BFE-4672-95F9-24D196CFAFAE-
dc.subject.meshAdult-
dc.subject.meshAnticoagulants-
dc.subject.meshFemale-
dc.subject.meshHemoglobins-
dc.subject.meshHumans-
dc.subject.meshKidney Transplantation-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshRetrospective Studies-
dc.subject.meshTransplantation, Homologous-
dc.subject.meshTreatment Outcome-
dc.subject.meshWarfarin-
dc.titleThe impact of peritransplant warfarin use on renal transplant outcome.en
dc.typeArticleen
dc.contributor.departmentDepartment of Nephrology, Beaumont Hospital, Dublin, Ireland.en
dc.identifier.journalJournal of nephrologyen
dc.description.provinceLeinster-

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