Morbidity and mortality in patients with craniopharyngioma after surgery.

Hdl Handle:
http://hdl.handle.net/10147/126490
Title:
Morbidity and mortality in patients with craniopharyngioma after surgery.
Authors:
Crowley, R K; Hamnvik, O P; O'Sullivan, E P; Behan, L A; Smith, D; Agha, A; Thompson, C J
Affiliation:
Academic Department of Endocrinology, Beaumont Hospital, Dublin, UK. rachelcrowley@hotmail.com
Citation:
Morbidity and mortality in patients with craniopharyngioma after surgery. 2010, 73 (4):516-21 Clin. Endocrinol. (Oxf)
Journal:
Clinical endocrinology
Issue Date:
Oct-2010
URI:
http://hdl.handle.net/10147/126490
DOI:
10.1111/j.1365-2265.2010.03838.x
PubMed ID:
20550527
Abstract:
Craniopharyngioma (CP) is a benign tumour of the suprasellar region that is associated with increased morbidity and mortality in comparison with other causes of hypopituitarism. We aimed to establish the rate and causes of mortality and morbidity in patients with CP who attended our centre.; We performed a retrospective case note audit of patients with CP who were managed by our service. We established the standardized mortality ratio (SMR) for patients with CP. We compared obesity prevalence with two other hypopituitary groups who are managed by our service.; We identified 70 patients with CP, 97% of whom had undergone surgery and 42% radiotherapy. We compared the prevalence of obesity with that of 89 patients with hypopituitarism secondary to surgery for nonfunctioning pituitary adenoma and 29 patients with post-traumatic hypopituitarism (PTHP).; Standardized mortality ratio for patients with CP was 8.75 (95% CI of 5.4-13.3); SMR for women was 10.51 (95% CI 5.04-19.3) and 7.55 (95% CI 3.77-13.52) for men. The rates of growth hormone (GH), gonadotrophin, adrenocorticotrophic hormone (ACTH) and TSH deficiencies were 91%, 93.5%, 92% and 86%, respectively. The rate of diabetes insipidus (DI) was 81%; 7.1% had adipsic DI. Dyslipidaemia was present in 46.9% and diabetes mellitus in 11.5%. Obesity affected 66% of patients with CP, 47% of patients with nonfunctioning adenoma and 31% of those with PTHP (P < 0.001).; Patients with CP suffer from high rates of mortality and morbidity. The underlying causes for mortality and for obesity in this population remain poorly understood.
Item Type:
Article
Language:
en
ISSN:
1365-2265

Full metadata record

DC FieldValue Language
dc.contributor.authorCrowley, R Ken
dc.contributor.authorHamnvik, O Pen
dc.contributor.authorO'Sullivan, E Pen
dc.contributor.authorBehan, L Aen
dc.contributor.authorSmith, Den
dc.contributor.authorAgha, Aen
dc.contributor.authorThompson, C Jen
dc.date.accessioned2011-03-31T09:26:33Z-
dc.date.available2011-03-31T09:26:33Z-
dc.date.issued2010-10-
dc.identifier.citationMorbidity and mortality in patients with craniopharyngioma after surgery. 2010, 73 (4):516-21 Clin. Endocrinol. (Oxf)en
dc.identifier.issn1365-2265-
dc.identifier.pmid20550527-
dc.identifier.doi10.1111/j.1365-2265.2010.03838.x-
dc.identifier.urihttp://hdl.handle.net/10147/126490-
dc.description.abstractCraniopharyngioma (CP) is a benign tumour of the suprasellar region that is associated with increased morbidity and mortality in comparison with other causes of hypopituitarism. We aimed to establish the rate and causes of mortality and morbidity in patients with CP who attended our centre.-
dc.description.abstractWe performed a retrospective case note audit of patients with CP who were managed by our service. We established the standardized mortality ratio (SMR) for patients with CP. We compared obesity prevalence with two other hypopituitary groups who are managed by our service.-
dc.description.abstractWe identified 70 patients with CP, 97% of whom had undergone surgery and 42% radiotherapy. We compared the prevalence of obesity with that of 89 patients with hypopituitarism secondary to surgery for nonfunctioning pituitary adenoma and 29 patients with post-traumatic hypopituitarism (PTHP).-
dc.description.abstractStandardized mortality ratio for patients with CP was 8.75 (95% CI of 5.4-13.3); SMR for women was 10.51 (95% CI 5.04-19.3) and 7.55 (95% CI 3.77-13.52) for men. The rates of growth hormone (GH), gonadotrophin, adrenocorticotrophic hormone (ACTH) and TSH deficiencies were 91%, 93.5%, 92% and 86%, respectively. The rate of diabetes insipidus (DI) was 81%; 7.1% had adipsic DI. Dyslipidaemia was present in 46.9% and diabetes mellitus in 11.5%. Obesity affected 66% of patients with CP, 47% of patients with nonfunctioning adenoma and 31% of those with PTHP (P < 0.001).-
dc.description.abstractPatients with CP suffer from high rates of mortality and morbidity. The underlying causes for mortality and for obesity in this population remain poorly understood.-
dc.language.isoenen
dc.titleMorbidity and mortality in patients with craniopharyngioma after surgery.en
dc.typeArticleen
dc.contributor.departmentAcademic Department of Endocrinology, Beaumont Hospital, Dublin, UK. rachelcrowley@hotmail.comen
dc.identifier.journalClinical endocrinologyen
dc.description.provinceLeinster-

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